Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | MG502 |
| A | HOH618 |
| A | HOH691 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | HOH618 |
| A | HOH632 |
| A | HOH663 |
| A | HOH681 |
| A | HOH714 |
| A | ASP201 |
| A | ZN501 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue AKU A 503 |
| Chain | Residue |
| A | HIS160 |
| A | MET273 |
| A | ASN321 |
| A | ILE336 |
| A | PHE340 |
| A | MET357 |
| A | GLN369 |
| A | PHE372 |
| A | HOH702 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | MG502 |
| B | HOH611 |
| B | HOH657 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 502 |
| Chain | Residue |
| B | ASP201 |
| B | ZN501 |
| B | HOH610 |
| B | HOH611 |
| B | HOH620 |
| B | HOH622 |
| B | HOH660 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue AKU B 503 |
| Chain | Residue |
| B | HIS160 |
| B | MET273 |
| B | ASN321 |
| B | ILE336 |
| B | PHE340 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | SER208 |
| B | PHE340 |
| B | PRO356 |
| B | CYS358 |
| B | HOH621 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| Chain | Residue | Details |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| A | ASN321 | |
| A | HIS160 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| B | HIS200 | |
| B | ASP318 | |
| A | HIS200 | |
| A | ASP318 | |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
