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6INM

Crystal structure of PDE4D complexed with a novel inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS164
AHIS200
AASP201
AASP318
AMG502
AHOH618
AHOH691

site_idAC2
Number of Residues7
Detailsbinding site for residue MG A 502
ChainResidue
AHOH618
AHOH632
AHOH663
AHOH681
AHOH714
AASP201
AZN501

site_idAC3
Number of Residues9
Detailsbinding site for residue AKU A 503
ChainResidue
AHIS160
AMET273
AASN321
AILE336
APHE340
AMET357
AGLN369
APHE372
AHOH702

site_idAC4
Number of Residues7
Detailsbinding site for residue ZN B 501
ChainResidue
BHIS164
BHIS200
BASP201
BASP318
BMG502
BHOH611
BHOH657

site_idAC5
Number of Residues7
Detailsbinding site for residue MG B 502
ChainResidue
BASP201
BZN501
BHOH610
BHOH611
BHOH620
BHOH622
BHOH660

site_idAC6
Number of Residues8
Detailsbinding site for residue AKU B 503
ChainResidue
BHIS160
BMET273
BASN321
BILE336
BPHE340
BMET357
BGLN369
BPHE372

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO B 504
ChainResidue
BSER208
BPHE340
BPRO356
BCYS358
BHOH621

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF
ChainResidueDetails
AHIS200-PHE211

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343
ChainResidueDetails
AHIS160
BHIS160

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
ChainResidueDetails
AGLN369
BHIS160
BASN321
BGLN369
AASN321
AHIS160

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3
ChainResidueDetails
AHIS164
BHIS164

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
ChainResidueDetails
BHIS200
BASP318
AHIS200
AASP318

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
ChainResidueDetails
AASP201
APHE372
BASP201
BPHE372

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PDB entries from 2024-06-12

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