Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6IMT

Crystal structure of PDE4D complexed with a novel inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS164
AHIS200
AASP201
AASP318
AHOH620
AHOH707

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 502
ChainResidue
AHOH662
AHOH704
AHOH773
AASP201
AHOH620
AHOH655

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 503
ChainResidue
ASER208
APRO356
AHOH626
AHOH658
AHOH779

site_idAC4
Number of Residues5
Detailsbinding site for residue EDO A 504
ChainResidue
AASN115
AALA155
AASN162
AILE163
AHOH711

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO A 505
ChainResidue
AARG330
AGLU366
ATYR406
AHOH675
BPRO411

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO A 506
ChainResidue
AASN402
AHOH608
AHOH755
BARG330

site_idAC7
Number of Residues3
Detailsbinding site for residue EDO A 507
ChainResidue
ALYS262
AASP266
AHOH652

site_idAC8
Number of Residues9
Detailsbinding site for residue AK0 A 508
ChainResidue
ATYR159
AMET273
AILE336
APHE340
AMET357
AGLN369
APHE372
AHOH643
AHOH647

site_idAC9
Number of Residues6
Detailsbinding site for residue ZN B 501
ChainResidue
BHIS164
BHIS200
BASP201
BASP318
BHOH615
BHOH688

site_idAD1
Number of Residues6
Detailsbinding site for residue MG B 502
ChainResidue
BASP201
BHOH615
BHOH631
BHOH643
BHOH667
BHOH721

site_idAD2
Number of Residues3
Detailsbinding site for residue EDO B 503
ChainResidue
BSER208
BPRO356
BHOH706

site_idAD3
Number of Residues5
Detailsbinding site for residue EDO B 504
ChainResidue
AASN224
BLYS262
BILE265
BASP266
BHOH625

site_idAD4
Number of Residues5
Detailsbinding site for residue EDO B 505
ChainResidue
BLEU175
BTHR178
BTRP384
BASP391
BALA392

site_idAD5
Number of Residues3
Detailsbinding site for residue EDO B 506
ChainResidue
AGLN327
AHOH644
BHOH699

site_idAD6
Number of Residues5
Detailsbinding site for residue EDO B 507
ChainResidue
BASN115
BALA155
BASN162
BILE163
BHOH612

site_idAD7
Number of Residues9
Detailsbinding site for residue AK0 B 508
ChainResidue
BTYR159
BMET273
BILE336
BPHE340
BMET357
BGLN369
BPHE372
BHOH632
BHOH634

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF
ChainResidueDetails
AHIS200-PHE211

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343
ChainResidueDetails
AHIS160
BHIS160

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
ChainResidueDetails
AGLN369
BHIS160
BASN321
BGLN369
AHIS160
AASN321

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3
ChainResidueDetails
AHIS164
BHIS164

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
ChainResidueDetails
BHIS200
BASP318
AHIS200
AASP318

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
ChainResidueDetails
AASP201
APHE372
BASP201
BPHE372

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon