Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HU9

III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005750	cellular_component	mitochondrial respiratory chain complex III
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005750	cellular_component	mitochondrial respiratory chain complex III
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0030061	cellular_component	mitochondrial crista
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0034399	cellular_component	nuclear periphery
F	0045333	biological_process	cellular respiration
F	0070469	cellular_component	respirasome
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0034551	biological_process	mitochondrial respiratory chain complex III assembly
G	0045333	biological_process	cellular respiration
G	0070469	cellular_component	respirasome
G	0099617	cellular_component	matrix side of mitochondrial inner membrane
G	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0045333	biological_process	cellular respiration
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005750	cellular_component	mitochondrial respiratory chain complex III
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
I	0009060	biological_process	aerobic respiration
I	0034551	biological_process	mitochondrial respiratory chain complex III assembly
I	0045333	biological_process	cellular respiration
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
J	0009060	biological_process	aerobic respiration
J	0045333	biological_process	cellular respiration
J	0070469	cellular_component	respirasome
J	1902600	biological_process	proton transmembrane transport
L	0004222	molecular_function	metalloendopeptidase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005750	cellular_component	mitochondrial respiratory chain complex III
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
L	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
L	0009060	biological_process	aerobic respiration
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	0070469	cellular_component	respirasome
L	1902600	biological_process	proton transmembrane transport
M	0004222	molecular_function	metalloendopeptidase activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005750	cellular_component	mitochondrial respiratory chain complex III
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006508	biological_process	proteolysis
M	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
M	0009060	biological_process	aerobic respiration
M	0030061	cellular_component	mitochondrial crista
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	0070469	cellular_component	respirasome
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005750	cellular_component	mitochondrial respiratory chain complex III
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
N	1902600	biological_process	proton transmembrane transport
O	0009055	molecular_function	electron transfer activity
O	0020037	molecular_function	heme binding
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005750	cellular_component	mitochondrial respiratory chain complex III
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0009060	biological_process	aerobic respiration
Q	0034399	cellular_component	nuclear periphery
Q	0045333	biological_process	cellular respiration
Q	0070469	cellular_component	respirasome
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005750	cellular_component	mitochondrial respiratory chain complex III
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0009060	biological_process	aerobic respiration
R	0034551	biological_process	mitochondrial respiratory chain complex III assembly
R	0045333	biological_process	cellular respiration
R	0070469	cellular_component	respirasome
R	0099617	cellular_component	matrix side of mitochondrial inner membrane
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
S	0009060	biological_process	aerobic respiration
S	0045333	biological_process	cellular respiration
S	0070469	cellular_component	respirasome
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005750	cellular_component	mitochondrial respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
T	0009060	biological_process	aerobic respiration
T	0034551	biological_process	mitochondrial respiratory chain complex III assembly
T	0045333	biological_process	cellular respiration
T	0070469	cellular_component	respirasome
T	1902600	biological_process	proton transmembrane transport
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
U	0009060	biological_process	aerobic respiration
U	0045333	biological_process	cellular respiration
U	0070469	cellular_component	respirasome
U	1902600	biological_process	proton transmembrane transport
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005751	cellular_component	mitochondrial respiratory chain complex IV
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0009060	biological_process	aerobic respiration
a	0015990	biological_process	electron transport coupled proton transport
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	0070469	cellular_component	respirasome
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005751	cellular_component	mitochondrial respiratory chain complex IV
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0046872	molecular_function	metal ion binding
b	0070469	cellular_component	respirasome
b	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005751	cellular_component	mitochondrial respiratory chain complex IV
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045333	biological_process	cellular respiration
c	1902600	biological_process	proton transmembrane transport
d	0005740	cellular_component	mitochondrial envelope
d	0005751	cellular_component	mitochondrial respiratory chain complex IV
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0005751	cellular_component	mitochondrial respiratory chain complex IV
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0005743	cellular_component	mitochondrial inner membrane
f	0005751	cellular_component	mitochondrial respiratory chain complex IV
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005751	cellular_component	mitochondrial respiratory chain complex IV
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016491	molecular_function	oxidoreductase activity
g	0031966	cellular_component	mitochondrial membrane
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
h	0005751	cellular_component	mitochondrial respiratory chain complex IV
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0004129	molecular_function	cytochrome-c oxidase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005751	cellular_component	mitochondrial respiratory chain complex IV
i	0006119	biological_process	oxidative phosphorylation
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0016491	molecular_function	oxidoreductase activity
i	1902600	biological_process	proton transmembrane transport
j	0004129	molecular_function	cytochrome-c oxidase activity
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005751	cellular_component	mitochondrial respiratory chain complex IV
j	0005758	cellular_component	mitochondrial intermembrane space
j	0006119	biological_process	oxidative phosphorylation
j	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0016491	molecular_function	oxidoreductase activity
j	0031966	cellular_component	mitochondrial membrane
j	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
j	0045277	cellular_component	respiratory chain complex IV
j	0045333	biological_process	cellular respiration
j	1902600	biological_process	proton transmembrane transport
k	0004129	molecular_function	cytochrome-c oxidase activity
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005751	cellular_component	mitochondrial respiratory chain complex IV
k	0006119	biological_process	oxidative phosphorylation
k	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
k	0009060	biological_process	aerobic respiration
k	0016491	molecular_function	oxidoreductase activity
k	0030234	molecular_function	enzyme regulator activity
k	0097250	biological_process	mitochondrial respirasome assembly
k	1902600	biological_process	proton transmembrane transport
l	0003674	molecular_function	molecular_function
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005746	cellular_component	mitochondrial respirasome
l	0005751	cellular_component	mitochondrial respiratory chain complex IV
l	0008150	biological_process	biological_process
m	0004129	molecular_function	cytochrome-c oxidase activity
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0005751	cellular_component	mitochondrial respiratory chain complex IV
m	0006119	biological_process	oxidative phosphorylation
m	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
m	0009060	biological_process	aerobic respiration
m	0015990	biological_process	electron transport coupled proton transport
m	0016020	cellular_component	membrane
m	0020037	molecular_function	heme binding
m	0031966	cellular_component	mitochondrial membrane
m	0045277	cellular_component	respiratory chain complex IV
m	0045333	biological_process	cellular respiration
m	0046872	molecular_function	metal ion binding
m	0070469	cellular_component	respirasome
n	0004129	molecular_function	cytochrome-c oxidase activity
n	0005507	molecular_function	copper ion binding
n	0005515	molecular_function	protein binding
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005751	cellular_component	mitochondrial respiratory chain complex IV
n	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
n	0009060	biological_process	aerobic respiration
n	0016020	cellular_component	membrane
n	0016491	molecular_function	oxidoreductase activity
n	0022900	biological_process	electron transport chain
n	0042773	biological_process	ATP synthesis coupled electron transport
n	0046872	molecular_function	metal ion binding
n	0070469	cellular_component	respirasome
n	1902600	biological_process	proton transmembrane transport
o	0004129	molecular_function	cytochrome-c oxidase activity
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005751	cellular_component	mitochondrial respiratory chain complex IV
o	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
o	0009055	molecular_function	electron transfer activity
o	0009060	biological_process	aerobic respiration
o	0016020	cellular_component	membrane
o	0019646	biological_process	aerobic electron transport chain
o	0022904	biological_process	respiratory electron transport chain
o	0031966	cellular_component	mitochondrial membrane
o	0045333	biological_process	cellular respiration
o	1902600	biological_process	proton transmembrane transport
p	0005740	cellular_component	mitochondrial envelope
p	0005751	cellular_component	mitochondrial respiratory chain complex IV
p	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
q	0005751	cellular_component	mitochondrial respiratory chain complex IV
q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
r	0005743	cellular_component	mitochondrial inner membrane
r	0005751	cellular_component	mitochondrial respiratory chain complex IV
r	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
s	0004129	molecular_function	cytochrome-c oxidase activity
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0005751	cellular_component	mitochondrial respiratory chain complex IV
s	0006119	biological_process	oxidative phosphorylation
s	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
s	0016491	molecular_function	oxidoreductase activity
s	0031966	cellular_component	mitochondrial membrane
s	0045333	biological_process	cellular respiration
s	1902600	biological_process	proton transmembrane transport
t	0005751	cellular_component	mitochondrial respiratory chain complex IV
t	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
u	0004129	molecular_function	cytochrome-c oxidase activity
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005751	cellular_component	mitochondrial respiratory chain complex IV
u	0006119	biological_process	oxidative phosphorylation
u	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
u	0016491	molecular_function	oxidoreductase activity
u	1902600	biological_process	proton transmembrane transport
v	0004129	molecular_function	cytochrome-c oxidase activity
v	0005739	cellular_component	mitochondrion
v	0005743	cellular_component	mitochondrial inner membrane
v	0005751	cellular_component	mitochondrial respiratory chain complex IV
v	0005758	cellular_component	mitochondrial intermembrane space
v	0006119	biological_process	oxidative phosphorylation
v	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
v	0016491	molecular_function	oxidoreductase activity
v	0031966	cellular_component	mitochondrial membrane
v	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
v	0045277	cellular_component	respiratory chain complex IV
v	0045333	biological_process	cellular respiration
v	1902600	biological_process	proton transmembrane transport
w	0004129	molecular_function	cytochrome-c oxidase activity
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005751	cellular_component	mitochondrial respiratory chain complex IV
w	0006119	biological_process	oxidative phosphorylation
w	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
w	0009060	biological_process	aerobic respiration
w	0016491	molecular_function	oxidoreductase activity
w	0030234	molecular_function	enzyme regulator activity
w	0097250	biological_process	mitochondrial respirasome assembly
w	1902600	biological_process	proton transmembrane transport
x	0003674	molecular_function	molecular_function
x	0005739	cellular_component	mitochondrion
x	0005743	cellular_component	mitochondrial inner membrane
x	0005746	cellular_component	mitochondrial respirasome
x	0005751	cellular_component	mitochondrial respiratory chain complex IV
x	0008150	biological_process	biological_process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PEF A 501

Chain	Residue
A	SER450
A	SER453
C	SER34
C	HIS222
C	PHE227
C	CDL604
D	LYS291
I	PCF101

site_id	AC2
Number of Residues	15
Details	binding site for residue HEM C 601

Chain	Residue
C	GLN43
C	GLY47
C	ILE48
C	MET50
C	ARG79
C	HIS82
C	ALA86
C	GLY131
C	VAL135
C	PHE180
C	HIS183
C	TYR184
C	PRO187
C	TYR274
C	LEU40

site_id	AC3
Number of Residues	15
Details	binding site for residue HEM C 602

Chain	Residue
C	TRP30
C	GLY33
C	LEU36
C	HIS96
C	MET97
C	LYS99
C	SER105
C	GLY117
C	VAL118
C	ILE120
C	VAL194
C	HIS197
C	LEU201
C	SER206
C	SER207

site_id	AC4
Number of Residues	7
Details	binding site for residue UQ6 C 603

Chain	Residue
C	LEU12
C	TYR16
C	MET199
N	LEU12
N	TYR16
N	ILE17
N	MET199

site_id	AC5
Number of Residues	10
Details	binding site for residue CDL C 604

Chain	Residue
A	HIS345
A	MET454
A	MET455
A	TRP457
A	PEF501
C	ARG4
C	ILE18
C	HIS222
C	PEF606
J	TRP33

site_id	AC6
Number of Residues	8
Details	binding site for residue PEF C 605

Chain	Residue
C	PHE3
C	SER6
C	ASN7
C	VAL8
C	TYR9
C	VAL13
N	THR112
N	ASN115

site_id	AC7
Number of Residues	5
Details	binding site for residue PEF C 606

Chain	Residue
A	HIS345
A	TRP457
C	ALA2
C	PHE3
C	CDL604

site_id	AC8
Number of Residues	9
Details	binding site for residue PCF C 607

Chain	Residue
C	TRP29
C	ALA98
C	TYR102
C	TYR103
C	THR317
C	PHE326
C	PHE327
H	GLN55
H	CDL601

site_id	AC9
Number of Residues	12
Details	binding site for residue HEC D 401

Chain	Residue
D	VAL100
D	CYS101
D	CYS104
D	HIS105
D	ASN169
D	ALA172
D	PRO175
D	ARG184
D	TYR190
D	PHE218
D	ALA224
D	MET225

site_id	AD1
Number of Residues	9
Details	binding site for residue PEF D 402

Chain	Residue
C	LEU81
C	MET237
D	LEU269
D	LYS272
D	THR273
D	ILE276
E	GLY70
E	SER73
E	THR77

site_id	AD2
Number of Residues	8
Details	binding site for residue FES E 301

Chain	Residue
E	HIS161
E	LEU162
E	GLY163
E	CYS164
E	CYS178
E	HIS181
E	SER183
E	CYS159

site_id	AD3
Number of Residues	10
Details	binding site for residue CDL E 302

Chain	Residue
D	TRP286
E	LYS44
E	LYS51
E	TYR55
E	PHE58
E	MET59
H	PRO36
H	PCF604
I	PHE3
e	LYS97

site_id	AD4
Number of Residues	10
Details	binding site for residue PEF E 303

Chain	Residue
E	GLU76
E	ILE79
E	SER80
E	THR83
J	PHE44
J	GLY47
J	TRP48
J	PRO49
N	ILE161
N	TRP164

site_id	AD5
Number of Residues	12
Details	binding site for residue CDL H 601

Chain	Residue
C	ASN27
C	TYR28
C	TRP29
C	PHE88
C	PCF607
G	HIS85
H	ALA44
H	SER48
H	ARG51
H	PHE52
H	GLN55
H	CDL602

site_id	AD6
Number of Residues	13
Details	binding site for residue CDL H 602

Chain	Residue
C	TYR28
D	TYR281
D	LEU282
D	ILE285
D	LYS288
D	LYS289
G	HIS85
H	ILE40
H	ASN43
H	ALA44
H	ASN47
H	ARG51
H	CDL601

site_id	AD7
Number of Residues	4
Details	binding site for residue PEF H 603

Chain	Residue
H	LYS53
H	SER54
H	LEU57
H	TYR58

site_id	AD8
Number of Residues	7
Details	binding site for residue PCF H 604

Chain	Residue
E	CDL302
H	GLY39
H	PHE41
H	HIS42
e	SER93
e	ALA96
e	LYS97

site_id	AD9
Number of Residues	12
Details	binding site for residue PCF I 101

Chain	Residue
A	ASP428
A	SER453
A	MET455
A	PEF501
E	TYR57
E	VAL60
E	GLY64
I	PHE11
I	LYS12
I	ASN14
I	PHE17
I	VAL18

site_id	AE1
Number of Residues	10
Details	binding site for residue CDL L 501

Chain	Residue
L	HIS345
L	MET454
L	MET455
L	TRP457
N	ARG4
N	HIS222
N	PEF603
N	PEF605
T	PCF101
U	TRP33

site_id	AE2
Number of Residues	16
Details	binding site for residue HEM N 601

Chain	Residue
N	GLN43
N	GLY47
N	ILE48
N	MET50
N	ARG79
N	HIS82
N	ALA83
N	ALA86
N	THR127
N	GLY131
N	VAL135
N	PHE180
N	HIS183
N	TYR184
N	PRO187
N	TYR274

site_id	AE3
Number of Residues	17
Details	binding site for residue HEM N 602

Chain	Residue
N	TRP30
N	GLY33
N	LEU36
N	GLY37
N	HIS96
N	MET97
N	LYS99
N	SER105
N	LEU113
N	TRP114
N	GLY117
N	VAL118
N	ILE120
N	VAL194
N	HIS197
N	SER206
N	SER207

site_id	AE4
Number of Residues	8
Details	binding site for residue PEF N 603

Chain	Residue
L	SER450
L	CDL501
N	SER34
N	HIS222
N	ILE226
N	PHE227
P	SER67
T	PCF101

site_id	AE5
Number of Residues	4
Details	binding site for residue PEF N 604

Chain	Residue
C	THR112
C	ASN115
N	PHE3
N	ASN7

site_id	AE6
Number of Residues	5
Details	binding site for residue PEF N 605

Chain	Residue
L	HIS345
L	TRP457
L	CDL501
N	PHE3
U	ARG17

site_id	AE7
Number of Residues	9
Details	binding site for residue PCF N 606

Chain	Residue
N	TRP29
N	ALA98
N	TYR102
N	TYR103
N	PHE327
N	VAL330
R	GLU82
S	VAL59
S	CDL601

site_id	AE8
Number of Residues	13
Details	binding site for residue HEC O 401

Chain	Residue
O	VAL100
O	CYS101
O	CYS104
O	HIS105
O	ASN169
O	ARG184
O	TYR190
O	ILE191
O	LEU195
O	PHE218
O	ILE223
O	MET225
O	VAL228

site_id	AE9
Number of Residues	11
Details	binding site for residue CDL O 402

Chain	Residue
N	TYR28
N	VAL231
O	TYR281
O	LEU282
O	LYS288
O	LYS289
P	CDL302
R	HIS85
S	ASN47
S	ARG51
S	CDL601

site_id	AF1
Number of Residues	8
Details	binding site for residue PEF O 403

Chain	Residue
N	ILE42
O	LEU269
O	LYS272
O	THR273
P	GLY70
P	SER73
P	THR77
P	PHE78

site_id	AF2
Number of Residues	8
Details	binding site for residue FES P 301

Chain	Residue
P	CYS159
P	HIS161
P	LEU162
P	GLY163
P	CYS164
P	CYS178
P	HIS181
P	SER183

site_id	AF3
Number of Residues	11
Details	binding site for residue CDL P 302

Chain	Residue
O	TRP286
O	CDL402
P	LYS44
P	LYS51
P	TYR55
P	PHE58
P	MET59
S	PRO36
S	LEU37
S	PHE41
T	PHE3

site_id	AF4
Number of Residues	9
Details	binding site for residue PEF P 303

Chain	Residue
C	ASP160
C	TRP164
P	GLU76
P	ILE79
P	SER80
P	THR83
U	PHE44
U	TRP48
U	PRO49

site_id	AF5
Number of Residues	9
Details	binding site for residue CDL S 601

Chain	Residue
N	ASN27
N	TYR28
N	TRP29
N	PCF606
O	CDL402
R	HIS85
S	SER48
S	ARG51
S	GLN55

site_id	AF6
Number of Residues	4
Details	binding site for residue PEF S 602

Chain	Residue
R	LYS40
S	LYS53
S	LEU57
S	TYR58

site_id	AF7
Number of Residues	8
Details	binding site for residue PCF S 603

Chain	Residue
S	GLN38
S	GLY39
S	ILE40
S	PHE41
S	HIS42
S	VAL45
q	SER93
q	LYS97

site_id	AF8
Number of Residues	12
Details	binding site for residue PCF T 101

Chain	Residue
L	ASP428
L	SER453
L	CDL501
N	PEF603
P	TYR57
P	VAL60
P	SER68
T	PHE11
T	LYS12
T	ASN14
T	PHE17
T	VAL18

site_id	AF9
Number of Residues	3
Details	binding site for residue CU a 601

Chain	Residue
a	HIS241
a	HIS290
a	HIS291

site_id	AG1
Number of Residues	24
Details	binding site for residue HEA a 602

Chain	Residue
a	PHE19
a	SER33
a	ARG37
a	VAL59
a	HIS62
a	ALA63
a	MET66
a	ILE67
a	VAL71
a	GLY126
a	TRP127
a	TYR371
a	PHE377
a	HIS378
a	LEU381
a	ILE386
a	LEU389
a	PHE390
a	ILE424
a	PHE425
a	MET428
a	ARG438
a	ARG439
a	LEU465

site_id	AG2
Number of Residues	20
Details	binding site for residue HEA a 603

Chain	Residue
a	TRP127
a	TRP237
a	VAL244
a	TYR245
a	HIS290
a	THR309
a	GLY317
a	GLY352
a	GLY355
a	LEU358
a	ALA359
a	ASP364
a	HIS368
a	VAL373
a	HIS376
a	PHE377
a	VAL380
a	LEU381
a	ARG438
b	ILE50

site_id	AG3
Number of Residues	4
Details	binding site for residue CA a 604

Chain	Residue
a	GLU39
a	ALA42
a	GLY44
a	PRO441

site_id	AG4
Number of Residues	3
Details	binding site for residue MG a 605

Chain	Residue
a	HIS368
a	ASP369
b	GLU223

site_id	AG5
Number of Residues	8
Details	binding site for residue PEF a 606

Chain	Residue
a	PHE268
a	ALA325
b	ILE75
b	ILE81
b	TRP85
i	LYS11
i	VAL14
i	PHE22

site_id	AG6
Number of Residues	9
Details	binding site for residue PEF a 607

Chain	Residue
a	TYR452
a	VAL453
a	ILE456
b	TYR21
e	PEF201
e	PCF202
l	VAL57
l	PHE60
l	SER61

site_id	AG7
Number of Residues	12
Details	binding site for residue PEF a 608

Chain	Residue
a	PHE95
a	PRO96
a	ARG97
a	ILE98
c	HIS15
c	SER62
c	TRP65
c	PHE66
c	ILE87
c	GLY90
c	PHE91
c	PHE94

site_id	AG8
Number of Residues	5
Details	binding site for residue CUA b 301

Chain	Residue
b	HIS186
b	CYS221
b	CYS225
b	MET232
b	CUA302

site_id	AG9
Number of Residues	5
Details	binding site for residue CUA b 302

Chain	Residue
b	CYS221
b	GLU223
b	CYS225
b	HIS229
b	CUA301

site_id	AH1
Number of Residues	11
Details	binding site for residue PEF b 303

Chain	Residue
a	HIS429
a	PHE430
a	TRP450
b	PRO20
b	TYR21
b	CYS23
e	SER148
i	PHE36
l	PRO54
l	GLY55
l	TYR58

site_id	AH2
Number of Residues	13
Details	binding site for residue PEF c 301

Chain	Residue
c	PHE66
c	ILE69
c	VAL70
c	ALA73
c	THR74
c	ILE87
c	ARG229
c	HIS234
c	THR236
c	HIS239
c	HIS240
c	VAL241
c	GLY242

site_id	AH3
Number of Residues	13
Details	binding site for residue PEF c 302

Chain	Residue
a	THR208
a	PHE216
c	TYR189
c	ALA192
c	PHE194
c	THR195
c	ILE196
c	TYR206
c	GLY210
k	THR114
k	LEU115
k	PHE116
k	ASN122

site_id	AH4
Number of Residues	4
Details	binding site for residue ZN d 201

Chain	Residue
d	CYS111
d	HIS119
d	CYS134
d	CYS137

site_id	AH5
Number of Residues	5
Details	binding site for residue PEF e 201

Chain	Residue
a	LEU334
a	TRP415
a	PEF607
e	SER92
e	ILE95

site_id	AH6
Number of Residues	8
Details	binding site for residue PCF e 202

Chain	Residue
a	TYR452
a	PEF607
e	ALA111
e	ARG114
e	MET115
e	GLY117
e	GLY118
e	ASP120

site_id	AH7
Number of Residues	8
Details	binding site for residue PEF h 101

Chain	Residue
a	PHE19
a	ILE400
h	PHE40
h	LYS41
h	ARG45
h	TYR49
h	SER52
h	PHE56

site_id	AH8
Number of Residues	3
Details	binding site for residue CU m 601

Chain	Residue
m	HIS241
m	HIS290
m	HIS291

site_id	AH9
Number of Residues	24
Details	binding site for residue HEA m 602

Chain	Residue
m	PHE19
m	SER33
m	ARG37
m	VAL59
m	HIS62
m	ALA63
m	MET66
m	ILE67
m	VAL71
m	GLY126
m	TRP127
m	TYR371
m	PHE377
m	HIS378
m	LEU381
m	ILE386
m	LEU389
m	PHE390
m	ILE424
m	PHE425
m	MET428
m	ARG438
m	ARG439
m	LEU465

site_id	AI1
Number of Residues	24
Details	binding site for residue HEA m 603

Chain	Residue
m	TRP127
m	THR128
m	TRP237
m	VAL244
m	TYR245
m	HIS290
m	HIS291
m	THR309
m	ALA313
m	THR316
m	GLY317
m	GLY352
m	GLY355
m	VAL356
m	LEU358
m	ALA359
m	ASP364
m	HIS368
m	HIS376
m	PHE377
m	VAL380
m	LEU381
m	ARG438
n	ILE50

site_id	AI2
Number of Residues	4
Details	binding site for residue CA m 604

Chain	Residue
m	GLU39
m	ALA42
m	GLY44
m	PRO441

site_id	AI3
Number of Residues	3
Details	binding site for residue MG m 605

Chain	Residue
m	HIS368
m	ASP369
n	GLU223

site_id	AI4
Number of Residues	8
Details	binding site for residue PEF m 606

Chain	Residue
m	PHE268
m	ALA325
n	ILE75
n	ILE81
n	PHE88
u	LYS11
u	VAL14
u	PHE22

site_id	AI5
Number of Residues	12
Details	binding site for residue PEF m 607

Chain	Residue
m	PHE95
m	ARG97
m	ILE98
o	HIS15
o	SER62
o	TRP65
o	PHE66
o	HIS79
o	GLY90
o	PHE91
o	PHE94
o	PEF301

site_id	AI6
Number of Residues	5
Details	binding site for residue CUA n 301

Chain	Residue
n	HIS186
n	CYS221
n	CYS225
n	MET232
n	CUA302

site_id	AI7
Number of Residues	5
Details	binding site for residue CUA n 302

Chain	Residue
n	CYS221
n	GLU223
n	CYS225
n	HIS229
n	CUA301

site_id	AI8
Number of Residues	10
Details	binding site for residue PEF n 303

Chain	Residue
m	PHE430
m	TRP450
n	PRO20
n	TYR21
n	CYS23
q	SER148
u	PHE36
x	PRO54
x	GLY55
x	TYR58

site_id	AI9
Number of Residues	7
Details	binding site for residue PEF n 304

Chain	Residue
m	VAL453
m	ILE456
n	TYR21
q	PEF201
q	PCF202
x	VAL57
x	PHE60

site_id	AJ1
Number of Residues	14
Details	binding site for residue PEF o 301

Chain	Residue
m	PEF607
o	PHE66
o	ILE69
o	VAL70
o	ALA73
o	THR74
o	ILE87
o	MET222
o	ARG229
o	HIS234
o	HIS239
o	HIS240
o	VAL241
o	GLY242

site_id	AJ2
Number of Residues	13
Details	binding site for residue PEF o 302

Chain	Residue
m	THR208
m	PHE216
o	TYR189
o	ALA192
o	PHE194
o	THR195
o	ILE196
o	TYR206
o	GLY210
w	THR114
w	LEU115
w	PHE116
w	ASN122

site_id	AJ3
Number of Residues	4
Details	binding site for residue ZN p 201

Chain	Residue
p	CYS111
p	HIS119
p	CYS134
p	CYS137

site_id	AJ4
Number of Residues	5
Details	binding site for residue PEF q 201

Chain	Residue
m	TRP415
m	PHE418
n	PEF304
q	SER92
q	ILE95

site_id	AJ5
Number of Residues	7
Details	binding site for residue PCF q 202

Chain	Residue
m	TYR452
m	ILE456
n	PEF304
q	ARG114
q	MET115
q	GLY118
q	ASP120

site_id	AJ6
Number of Residues	8
Details	binding site for residue PEF t 101

Chain	Residue
m	PHE19
m	ILE400
t	PHE40
t	LYS41
t	ARG45
t	TYR49
t	SER52
t	PHE56

Functional Information from PROSITE/UniProt

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
p	ILE121-LEU143

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
n	VAL184-MET232

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
k	ILE101-ASN118

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
m	TRP237-HIS291

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:30598554, ECO:0000305\|PubMed:27083394

Chain	Residue	Details
l	SER9-SER27
x	SER9-SER27
m	GLY89-ARG97
m	MET172-PRO183
m	LYS264-GLY269
m	HIS328-ALA335
m	LEU401-ASN406
m	GLN475-SER534
p	CYS134
p	CYS137
d	CYS134
d	CYS137
p	CYS111
p	HIS119

site_id	SWS_FT_FI2
Number of Residues	72
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
l	TRP28-ARG64
x	TRP28-ARG64
C	VAL111-VAL135
C	ASN173-HIS204
C	TYR224-TYR246
C	LYS288-THR308
C	VAL320-GLY340
C	TYR348-LEU364
N	TYR28-ALA51
N	GLY75-TYR102
N	VAL111-VAL135
N	ASN173-HIS204
N	TYR224-TYR246
N	LYS288-THR308
N	VAL320-GLY340
N	TYR348-LEU364

site_id	SWS_FT_FI3
Number of Residues	2
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:30598554, ECO:0000305\|PubMed:27083394

Chain	Residue	Details
l	LYS65-ALA66
x	LYS65-ALA66
c	TYR189-TYR201
c	TRP266-VAL269
o	HIS42-MET48
o	SER115-LEU137
o	TYR189-TYR201
o	TRP266-VAL269
m	PHE216-ASP228
m	GLY296-ASP298
m	ALA359-THR370
m	GLY432-GLY449

site_id	SWS_FT_FI4
Number of Residues	48
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	ASN49-ALA73
o	ASN49-ALA73
P	CYS159
P	HIS161
P	CYS178
P	HIS181
E	CYS178
E	HIS181

site_id	SWS_FT_FI5
Number of Residues	66
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	MET81-MET114
o	MET81-MET114
n	HIS186
n	CYS221
n	CYS225
n	MET232
b	CYS225
b	MET232

site_id	SWS_FT_FI6
Number of Residues	46
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	PRO138-ALA161
o	PRO138-ALA161
n	GLU223
n	HIS229

site_id	SWS_FT_FI7
Number of Residues	46
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	ASN165-GLU188
o	ASN165-GLU188

site_id	SWS_FT_FI8
Number of Residues	56
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	GLY202-MET230
o	GLY202-MET230

site_id	SWS_FT_FI9
Number of Residues	32
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	TYR249-TYR265
o	TYR249-TYR265

site_id	SWS_FT_FI10
Number of Residues	56
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	ALA299-ILE327
m	ALA299-ILE327

site_id	SWS_FT_FI11
Number of Residues	44
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	THR336-LEU358
m	THR336-LEU358

site_id	SWS_FT_FI12
Number of Residues	58
Details	TRANSMEM: Helical; Name=10 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	TYR371-ILE400
m	TYR371-ILE400

site_id	SWS_FT_FI13
Number of Residues	48
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	GLU407-LEU431
m	GLU407-LEU431

site_id	SWS_FT_FI14
Number of Residues	48
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	TRP450-ASP474
m	TRP450-ASP474

site_id	SWS_FT_FI15
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556

Chain	Residue	Details
a	GLY44
a	HIS241
a	HIS290
a	HIS291
a	HIS368
a	ASP369
a	PRO441
m	GLU39
m	ALA42
m	GLY44
m	HIS241
m	HIS290
m	HIS291
m	HIS368
m	ASP369
m	PRO441
a	GLU39
a	ALA42

site_id	SWS_FT_FI16
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556

Chain	Residue	Details
a	HIS62
a	HIS378
m	HIS62
m	HIS378

site_id	SWS_FT_FI17
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
a	TYR245
m	TYR245

site_id	SWS_FT_FI18
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	HIS376
m	HIS376

site_id	SWS_FT_FI19
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	HIS241
a	TYR245
m	HIS241
m	TYR245

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
E	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
C	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
C	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
P	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
N	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
N	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
N	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
N	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)