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6GNS

Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and an Azepanyl Phenyl Benzylsulphonamide Ligand

Functional Information from GO Data
ChainGOidnamespacecontents
A0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
A0005737cellular_componentcytoplasm
A0006499biological_processN-terminal protein myristoylation
A0016746molecular_functionacyltransferase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues38
Detailsbinding site for residue MYA A 1001
ChainResidue
AHIS12
ACYS170
AVAL171
AARG176
AGLU177
ALYS178
AARG179
ALEU180
AALA181
APRO182
ATHR189
AALA13
AVAL192
AASN193
ATRP198
AALA200
ATYR202
ATHR203
ALEU208
ATYR404
AHOH1132
AHOH1138
APHE14
AHOH1142
AHOH1150
AHOH1154
AHOH1158
AHOH1189
AHOH1196
AHOH1323
AHOH1326
AHOH1344
ATRP15
AASN79
ATYR80
AVAL81
APHE168
ALEU169

site_idAC2
Number of Residues17
Detailsbinding site for residue F65 A 1002
ChainResidue
AVAL81
AASP83
APHE88
APHE90
AASN167
ATHR203
ATYR217
AHIS219
AARG231
ASER330
AASN376
AGLY395
AASP396
AGLY397
ALEU421
AHOH1211
AHOH1220

Functional Information from PROSITE/UniProt
site_idPS00975
Number of Residues9
DetailsNMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK
ChainResidueDetails
AGLU165-LYS173

site_idPS00976
Number of Residues7
DetailsNMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGaGDG
ChainResidueDetails
ALYS391-GLY397

219869

PDB entries from 2024-05-15

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