Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GB5

Structure of H-2Db with truncated SEV peptide and GL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001913	biological_process	T cell mediated cytotoxicity
A	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0002476	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class Ib
A	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
A	0002486	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0009897	cellular_component	external side of plasma membrane
A	0010977	biological_process	negative regulation of neuron projection development
A	0016020	cellular_component	membrane
A	0019882	biological_process	antigen processing and presentation
A	0030670	cellular_component	phagocytic vesicle membrane
A	0030881	molecular_function	beta-2-microglobulin binding
A	0042277	molecular_function	peptide binding
A	0042605	molecular_function	peptide antigen binding
A	0042612	cellular_component	MHC class I protein complex
A	0044877	molecular_function	protein-containing complex binding
A	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
C	0001913	biological_process	T cell mediated cytotoxicity
C	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0002476	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class Ib
C	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
C	0002486	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0009897	cellular_component	external side of plasma membrane
C	0010977	biological_process	negative regulation of neuron projection development
C	0016020	cellular_component	membrane
C	0019882	biological_process	antigen processing and presentation
C	0030670	cellular_component	phagocytic vesicle membrane
C	0030881	molecular_function	beta-2-microglobulin binding
C	0042277	molecular_function	peptide binding
C	0042605	molecular_function	peptide antigen binding
C	0042612	cellular_component	MHC class I protein complex
C	0044877	molecular_function	protein-containing complex binding
C	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0006968	biological_process	cellular defense response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0010977	biological_process	negative regulation of neuron projection development
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031902	cellular_component	late endosome membrane
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 401

Chain	Residue
A	ARG121
A	MET138
A	ARG145
A	HOH513
B	ILE1

site_id	AC2
Number of Residues	1
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG111

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 403

Chain	Residue
A	ASN30
A	HOH501
A	ARG6
A	PHE8
A	TYR27

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 C 401

Chain	Residue
C	PRO15
C	ALA89
C	GLY90

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 C 402

Chain	Residue
C	ARG144
C	ARG145

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 C 403

Chain	Residue
C	ARG111

site_id	AC7
Number of Residues	1
Details	binding site for residue SO4 C 404

Chain	Residue
C	TRP167

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL C 405

Chain	Residue
C	ARG6
C	TYR27
C	ASN30

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL D 101

Chain	Residue
C	ARG234
D	ILE7
D	GLN8
D	VAL9
D	TYR94
D	ASP96
D	MET99

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCRVYH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	568
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLY1-VAL285
C	GLY1-VAL285

site_id	SWS_FT_FI2
Number of Residues	42
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE286-MET307
C	ILE286-MET307

site_id	SWS_FT_FI3
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS308-ALA338
C	LYS308-ALA338

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate => ECO:0000250\|UniProtKB:P01900

Chain	Residue	Details
A	SER329
C	SER329

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P01900

Chain	Residue	Details
A	SER332
C	SER332

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN86
C	ASN86

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
C	ASN176
A	ASN176

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN256
C	ASN256

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl serine ester (Ser-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000305\|PubMed:19951915

Chain	Residue	Details
A	SER329
C	SER329

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)