6FO5

FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR #17

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue DZH A 201

Chain	Residue
A	PRO47
A	ASP145
A	MET149
A	EDO202
A	HOH309
A	HOH314
A	HOH346
A	HOH354
A	HOH386
A	HOH387
A	HOH402
A	GLU49
A	THR50
A	SER51
A	PRO82
A	PHE83
A	VAL87
A	LEU94
A	ASN140

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 202

Chain	Residue
A	PRO47
A	ASN121
A	DZH201
A	HOH308
A	HOH310
A	HOH344

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

---