6F88
Crystal structure of cytochrome P450 CYP260A1 (S276N) bound with progesterone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006707 | biological_process | cholesterol catabolic process |
| B | 0008395 | molecular_function | steroid hydroxylase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | LEU73 |
| A | THR233 |
| A | THR234 |
| A | LEU237 |
| A | ASN276 |
| A | GLY278 |
| A | VAL279 |
| A | ARG281 |
| A | VAL332 |
| A | PHE333 |
| A | GLY334 |
| A | ALA74 |
| A | GLY335 |
| A | HIS338 |
| A | CYS340 |
| A | VAL341 |
| A | GLY342 |
| A | STR502 |
| A | HOH785 |
| A | HOH850 |
| A | HIS81 |
| A | ARG85 |
| A | TYR88 |
| A | PHE92 |
| A | LEU226 |
| A | GLY229 |
| A | GLY230 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue STR A 502 |
| Chain | Residue |
| A | LEU69 |
| A | SER225 |
| A | ASN276 |
| A | PHE277 |
| A | GLY278 |
| A | VAL382 |
| A | HEM501 |
| A | HOH613 |
| A | HOH788 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | LEU73 |
| B | ALA74 |
| B | HIS81 |
| B | ARG85 |
| B | SER225 |
| B | LEU226 |
| B | GLY229 |
| B | GLY230 |
| B | THR233 |
| B | THR234 |
| B | LEU237 |
| B | SER275 |
| B | ASN276 |
| B | GLY278 |
| B | VAL279 |
| B | ARG281 |
| B | VAL332 |
| B | PHE333 |
| B | GLY334 |
| B | HIS338 |
| B | CYS340 |
| B | VAL341 |
| B | GLY342 |
| B | LEU345 |
| B | ALA346 |
| B | STR502 |
| B | HOH613 |
| B | HOH630 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue STR B 502 |
| Chain | Residue |
| B | LEU69 |
| B | SER225 |
| B | ASN276 |
| B | GLY278 |
| B | VAL382 |
| B | HEM501 |
| B | HOH656 |
| B | HOH657 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGAHFCVG |
| Chain | Residue | Details |
| A | PHE333-GLY342 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27878817, ECO:0000269|PubMed:29509407, ECO:0007744|PDB:5LIV, ECO:0007744|PDB:6F85, ECO:0007744|PDB:6F88, ECO:0007744|PDB:6F8A, ECO:0007744|PDB:6F8C |
| Chain | Residue | Details |
| A | CYS340 | |
| B | CYS340 |
