6EO0
Zebrafish Sirt5 in complex with stalled peptidylimidate and bicyclic intermediate of inhibitory compound 29
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| B | 0070403 | molecular_function | NAD+ binding |
| C | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| C | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| C | 0070403 | molecular_function | NAD+ binding |
| D | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| D | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| D | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | CYS162 |
| A | CYS165 |
| A | CYS203 |
| A | CYS208 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | GLU286 |
| B | PRO69 |
| site_id | AC3 |
| Number of Residues | 31 |
| Details | binding site for residue BV8 A 303 |
| Chain | Residue |
| A | ALA59 |
| A | GLU60 |
| A | THR65 |
| A | PHE66 |
| A | ARG67 |
| A | TYR98 |
| A | ARG101 |
| A | GLN136 |
| A | HIS154 |
| A | VAL217 |
| A | PHE219 |
| A | GLY220 |
| A | GLU221 |
| A | THR222 |
| A | LEU223 |
| A | GLY245 |
| A | THR246 |
| A | SER247 |
| A | VAL250 |
| A | TYR251 |
| A | ASN271 |
| A | MET272 |
| A | GLU273 |
| A | CYS289 |
| A | BVT304 |
| C | TYR251 |
| C | MET255 |
| C | PHE256 |
| A | GLY54 |
| A | ALA55 |
| A | GLY56 |
| site_id | AC4 |
| Number of Residues | 33 |
| Details | binding site for residue BVT A 304 |
| Chain | Residue |
| A | GLY54 |
| A | ALA55 |
| A | GLY56 |
| A | ALA59 |
| A | GLU60 |
| A | THR65 |
| A | PHE66 |
| A | ARG67 |
| A | ALA82 |
| A | TYR98 |
| A | ARG101 |
| A | GLN136 |
| A | ILE138 |
| A | HIS154 |
| A | VAL217 |
| A | PHE219 |
| A | GLY220 |
| A | GLU221 |
| A | THR222 |
| A | LEU223 |
| A | GLY245 |
| A | THR246 |
| A | SER247 |
| A | VAL250 |
| A | TYR251 |
| A | ASN271 |
| A | MET272 |
| A | GLU273 |
| A | CYS289 |
| A | BV8303 |
| C | TYR251 |
| C | MET255 |
| C | PHE256 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS162 |
| B | CYS165 |
| B | CYS203 |
| B | CYS208 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| A | LYS28 |
| B | GLU85 |
| B | ARG89 |
| B | HOH409 |
| D | SER262 |
| site_id | AC7 |
| Number of Residues | 36 |
| Details | binding site for residue BVT B 303 |
| Chain | Residue |
| B | THR246 |
| B | SER247 |
| B | VAL250 |
| B | TYR251 |
| B | ASN271 |
| B | MET272 |
| B | GLU273 |
| B | CYS289 |
| D | LEU228 |
| D | TYR251 |
| D | MET255 |
| D | PHE256 |
| D | PRO258 |
| D | GLN259 |
| D | ARG280 |
| D | EDO302 |
| B | GLY54 |
| B | ALA55 |
| B | GLY56 |
| B | ALA59 |
| B | GLU60 |
| B | THR65 |
| B | PHE66 |
| B | ARG67 |
| B | ALA82 |
| B | TYR98 |
| B | ARG101 |
| B | GLN136 |
| B | ILE138 |
| B | HIS154 |
| B | VAL217 |
| B | PHE219 |
| B | GLY220 |
| B | GLU221 |
| B | THR222 |
| B | GLY245 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | CYS162 |
| C | CYS165 |
| C | CYS203 |
| C | CYS208 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 302 |
| Chain | Residue |
| A | LEU228 |
| C | LEU223 |
| C | LEU228 |
| site_id | AD1 |
| Number of Residues | 37 |
| Details | binding site for residue BVT C 303 |
| Chain | Residue |
| A | TYR251 |
| A | MET255 |
| A | PHE256 |
| A | PRO258 |
| A | GLN259 |
| C | GLY54 |
| C | ALA55 |
| C | GLY56 |
| C | ALA59 |
| C | GLU60 |
| C | THR65 |
| C | PHE66 |
| C | ARG67 |
| C | ALA82 |
| C | TYR98 |
| C | ARG101 |
| C | GLN136 |
| C | ILE138 |
| C | HIS154 |
| C | VAL217 |
| C | TRP218 |
| C | PHE219 |
| C | GLY220 |
| C | GLU221 |
| C | THR222 |
| C | GLY245 |
| C | THR246 |
| C | SER247 |
| C | VAL250 |
| C | TYR251 |
| C | ASN271 |
| C | MET272 |
| C | GLU273 |
| C | CYS289 |
| C | HOH405 |
| C | HOH412 |
| C | HOH422 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | CYS162 |
| D | CYS165 |
| D | CYS203 |
| D | CYS208 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 302 |
| Chain | Residue |
| B | BVT303 |
| D | HOH417 |
| site_id | AD4 |
| Number of Residues | 32 |
| Details | binding site for residue BVT D 303 |
| Chain | Residue |
| B | MET255 |
| B | PHE256 |
| B | GLN259 |
| D | GLY54 |
| D | ALA55 |
| D | GLY56 |
| D | ALA59 |
| D | THR65 |
| D | PHE66 |
| D | ARG67 |
| D | ALA82 |
| D | TYR98 |
| D | ARG101 |
| D | GLN136 |
| D | HIS154 |
| D | VAL216 |
| D | VAL217 |
| D | PHE219 |
| D | GLY220 |
| D | GLU221 |
| D | THR222 |
| D | GLY245 |
| D | THR246 |
| D | SER247 |
| D | VAL250 |
| D | TYR251 |
| D | ASN271 |
| D | MET272 |
| D | GLU273 |
| D | GLY287 |
| D | PRO288 |
| D | CYS289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
| Chain | Residue | Details |
| A | HIS154 | |
| B | HIS154 | |
| C | HIS154 | |
| D | HIS154 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
| Chain | Residue | Details |
| A | CYS162 | |
| A | CYS165 | |
| A | CYS203 | |
| A | CYS208 | |
| A | GLY245 | |
| A | ASN271 | |
| A | CYS289 | |
| B | GLY54 | |
| B | TYR98 | |
| B | ARG101 | |
| B | GLN136 | |
| B | CYS162 | |
| B | CYS165 | |
| B | CYS203 | |
| B | CYS208 | |
| B | GLY245 | |
| B | ASN271 | |
| B | CYS289 | |
| C | GLY54 | |
| C | TYR98 | |
| C | ARG101 | |
| C | GLN136 | |
| C | CYS162 | |
| C | CYS165 | |
| C | CYS203 | |
| C | CYS208 | |
| C | GLY245 | |
| C | ASN271 | |
| C | CYS289 | |
| D | GLY54 | |
| D | TYR98 | |
| D | ARG101 | |
| D | GLN136 | |
| D | CYS162 | |
| D | CYS165 | |
| D | CYS203 | |
| D | CYS208 | |
| D | GLY245 | |
| D | ASN271 | |
| D | CYS289 | |
| A | GLY54 | |
| A | TYR98 | |
| A | ARG101 | |
| A | GLN136 |
