6EA2
X-ray crystal structure of Pf-M1 in complex with inhibitor (6h) and catalytic zinc ion
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1101 |
Chain | Residue |
A | HIS496 |
A | HIS500 |
A | GLU519 |
A | J1G1102 |
site_id | AC2 |
Number of Residues | 18 |
Details | binding site for residue J1G A 1102 |
Chain | Residue |
A | VAL459 |
A | GLY460 |
A | ALA461 |
A | GLU463 |
A | HIS496 |
A | GLU497 |
A | HIS500 |
A | GLU519 |
A | GLU572 |
A | TYR575 |
A | TYR580 |
A | MET1034 |
A | ZN1101 |
A | THR305 |
A | GLN317 |
A | GLU319 |
A | ALA320 |
A | ASN458 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue DMS A 1103 |
Chain | Residue |
A | ASN573 |
A | THR1037 |
A | TYR1077 |
A | HOH1541 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue DMS A 1104 |
Chain | Residue |
A | HIS653 |
A | LYS676 |
A | TYR741 |
A | ASN835 |
A | PHE836 |
A | HOH1525 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue GOL A 1105 |
Chain | Residue |
A | LYS479 |
A | TYR880 |
A | VAL887 |
A | ASP888 |
A | GLN891 |
A | ARG895 |
A | TYR925 |
A | HOH1567 |
A | HOH1716 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue GOL A 1106 |
Chain | Residue |
A | VAL459 |
A | GLY460 |
A | ASN471 |
A | ASN473 |
A | SER474 |
A | ARG489 |
A | ASN994 |
A | ARG997 |
A | HOH1298 |
A | HOH2052 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue GOL A 1107 |
Chain | Residue |
A | ALA303 |
A | THR305 |
A | ARG325 |
A | GLU572 |
A | PRO1033 |
A | HOH1360 |
A | HOH1441 |
A | HOH1597 |
A | HOH1837 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue MG A 1108 |
Chain | Residue |
A | GLY250 |
A | HOH1345 |
A | HOH1670 |
A | HOH1796 |
A | HOH1801 |
A | HOH2056 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue MG A 1109 |
Chain | Residue |
A | HOH1381 |
A | HOH1623 |
A | HOH1767 |
A | HOH2261 |
A | HOH2450 |
A | HOH2479 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue MG A 1110 |
Chain | Residue |
A | HOH1648 |
A | HOH1766 |
A | HOH1981 |
A | HOH2241 |
A | HOH2408 |
A | HOH2569 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue MG A 1111 |
Chain | Residue |
A | ASN1083 |
A | HOH1436 |
A | HOH1612 |
A | HOH1660 |
A | HOH2137 |
A | HOH2379 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHQY |
Chain | Residue | Details |
A | VAL493-TYR502 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | GLU497 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3EBI, ECO:0007744|PDB:3Q43 |
Chain | Residue | Details |
A | GLU319 | |
A | GLY460 | |
A | GLU463 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3Q43 |
Chain | Residue | Details |
A | ALA461 |
Chain | Residue | Details |
A | HIS496 | |
A | HIS500 | |
A | GLU519 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Important for substrate specificity => ECO:0000269|PubMed:23897806 |
Chain | Residue | Details |
A | VAL459 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | TYR580 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Cleavage => ECO:0000305|PubMed:21659511 |
Chain | Residue | Details |
A | GLN795 |