6D96

Structure of influenza neuraminidase from strain A/BrevigMission/1/1918(H1N1) expressed in HEK-293E cells

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane
A	0033644	cellular_component	host cell membrane
A	0046761	biological_process	viral budding from plasma membrane
A	0055036	cellular_component	virion membrane
B	0004308	molecular_function	exo-alpha-sialidase activity
B	0005975	biological_process	carbohydrate metabolic process
B	0016020	cellular_component	membrane
B	0033644	cellular_component	host cell membrane
B	0046761	biological_process	viral budding from plasma membrane
B	0055036	cellular_component	virion membrane
C	0004308	molecular_function	exo-alpha-sialidase activity
C	0005975	biological_process	carbohydrate metabolic process
C	0016020	cellular_component	membrane
C	0033644	cellular_component	host cell membrane
C	0046761	biological_process	viral budding from plasma membrane
C	0055036	cellular_component	virion membrane
D	0004308	molecular_function	exo-alpha-sialidase activity
D	0005975	biological_process	carbohydrate metabolic process
D	0016020	cellular_component	membrane
D	0033644	cellular_component	host cell membrane
D	0046761	biological_process	viral budding from plasma membrane
D	0055036	cellular_component	virion membrane
E	0004308	molecular_function	exo-alpha-sialidase activity
E	0005975	biological_process	carbohydrate metabolic process
E	0016020	cellular_component	membrane
E	0033644	cellular_component	host cell membrane
E	0046761	biological_process	viral budding from plasma membrane
E	0055036	cellular_component	virion membrane
F	0004308	molecular_function	exo-alpha-sialidase activity
F	0005975	biological_process	carbohydrate metabolic process
F	0016020	cellular_component	membrane
F	0033644	cellular_component	host cell membrane
F	0046761	biological_process	viral budding from plasma membrane
F	0055036	cellular_component	virion membrane
G	0004308	molecular_function	exo-alpha-sialidase activity
G	0005975	biological_process	carbohydrate metabolic process
G	0016020	cellular_component	membrane
G	0033644	cellular_component	host cell membrane
G	0046761	biological_process	viral budding from plasma membrane
G	0055036	cellular_component	virion membrane
H	0004308	molecular_function	exo-alpha-sialidase activity
H	0005975	biological_process	carbohydrate metabolic process
H	0016020	cellular_component	membrane
H	0033644	cellular_component	host cell membrane
H	0046761	biological_process	viral budding from plasma membrane
H	0055036	cellular_component	virion membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASP151
B	ASP151
C	ASP151
D	ASP151
E	ASP151
F	ASP151
G	ASP151
H	ASP151

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	TYR406
B	TYR406
C	TYR406
D	TYR406
E	TYR406
F	TYR406
G	TYR406
H	TYR406

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
E	ARG371
F	ARG118
F	ARG152
F	GLU276
F	ARG292
F	ARG371
G	ARG118
G	ARG152
G	GLU276
G	ARG292
G	ARG371
H	ARG118
H	ARG152
H	GLU276
H	ARG292
H	ARG371
A	ARG118
A	ARG152
A	GLU276
A	ARG292
A	ARG371
B	ARG118
B	ARG152
B	GLU276
B	ARG292
E	GLU276
E	ARG292
B	ARG371
C	ARG118
C	ARG152
C	GLU276
C	ARG292
C	ARG371
D	ARG118
D	ARG152
D	GLU276
D	ARG292
D	ARG371
E	ARG118
E	ARG152

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:18715929

Chain	Residue	Details
C	ASP293
C	GLY297
C	ASP324
C	ASN347
D	ASP293
D	GLY297
D	ASP324
D	ASN347
E	ASP293
E	GLY297
E	ASP324
E	ASN347
F	ASP293
F	GLY297
F	ASP324
F	ASN347
G	ASP293
G	GLY297
G	ASP324
G	ASN347
H	ASP293
H	GLY297
H	ASP324
H	ASN347
A	ASP293
A	GLY297
A	ASP324
A	ASN347
B	ASP293
B	GLY297
B	ASP324
B	ASN347

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASN88
A	ASN234
B	ASN88
B	ASN234
C	ASN88
C	ASN234
D	ASN88
D	ASN234
E	ASN88
E	ASN234
F	ASN88
F	ASN234
G	ASN88
G	ASN234
H	ASN88
H	ASN234

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:18715929

Chain	Residue	Details
A	ASN146
B	ASN146
C	ASN146
D	ASN146
E	ASN146
F	ASN146
G	ASN146
H	ASN146

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