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6CXJ

Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001738biological_processmorphogenesis of a polarized epithelium
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005522molecular_functionprofilin binding
A0005524molecular_functionATP binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0007409biological_processaxonogenesis
A0010628biological_processpositive regulation of gene expression
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019901molecular_functionprotein kinase binding
A0030016cellular_componentmyofibril
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0031625molecular_functionubiquitin protein ligase binding
A0031941cellular_componentfilamentous actin
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0035633biological_processmaintenance of blood-brain barrier
A0042802molecular_functionidentical protein binding
A0043296cellular_componentapical junction complex
A0044305cellular_componentcalyx of Held
A0045177cellular_componentapical part of cell
A0045202cellular_componentsynapse
A0045214biological_processsarcomere organization
A0045335cellular_componentphagocytic vesicle
A0048870biological_processcell motility
A0051492biological_processregulation of stress fiber assembly
A0051893biological_processregulation of focal adhesion assembly
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071346biological_processcellular response to type II interferon
A0072562cellular_componentblood microparticle
A0090303biological_processpositive regulation of wound healing
A0097433cellular_componentdense body
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0120192biological_processtight junction assembly
A0120220cellular_componentbasal body patch
A0150111biological_processregulation of transepithelial transport
A1900242biological_processregulation of synaptic vesicle endocytosis
A1902396biological_processprotein localization to bicellular tight junction
B0001525biological_processangiogenesis
B0001738biological_processmorphogenesis of a polarized epithelium
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005522molecular_functionprofilin binding
B0005524molecular_functionATP binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0007409biological_processaxonogenesis
B0010628biological_processpositive regulation of gene expression
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019901molecular_functionprotein kinase binding
B0030016cellular_componentmyofibril
B0030335biological_processpositive regulation of cell migration
B0030424cellular_componentaxon
B0031625molecular_functionubiquitin protein ligase binding
B0031941cellular_componentfilamentous actin
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0035633biological_processmaintenance of blood-brain barrier
B0042802molecular_functionidentical protein binding
B0043296cellular_componentapical junction complex
B0044305cellular_componentcalyx of Held
B0045177cellular_componentapical part of cell
B0045202cellular_componentsynapse
B0045214biological_processsarcomere organization
B0045335cellular_componentphagocytic vesicle
B0048870biological_processcell motility
B0051492biological_processregulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0070062cellular_componentextracellular exosome
B0070527biological_processplatelet aggregation
B0071346biological_processcellular response to type II interferon
B0072562cellular_componentblood microparticle
B0090303biological_processpositive regulation of wound healing
B0097433cellular_componentdense body
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0120192biological_processtight junction assembly
B0120220cellular_componentbasal body patch
B0150111biological_processregulation of transepithelial transport
B1900242biological_processregulation of synaptic vesicle endocytosis
B1902396biological_processprotein localization to bicellular tight junction
C0001525biological_processangiogenesis
C0001738biological_processmorphogenesis of a polarized epithelium
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005522molecular_functionprofilin binding
C0005524molecular_functionATP binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005925cellular_componentfocal adhesion
C0007409biological_processaxonogenesis
C0010628biological_processpositive regulation of gene expression
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019901molecular_functionprotein kinase binding
C0030016cellular_componentmyofibril
C0030335biological_processpositive regulation of cell migration
C0030424cellular_componentaxon
C0031625molecular_functionubiquitin protein ligase binding
C0031941cellular_componentfilamentous actin
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0035633biological_processmaintenance of blood-brain barrier
C0042802molecular_functionidentical protein binding
C0043296cellular_componentapical junction complex
C0044305cellular_componentcalyx of Held
C0045177cellular_componentapical part of cell
C0045202cellular_componentsynapse
C0045214biological_processsarcomere organization
C0045335cellular_componentphagocytic vesicle
C0048870biological_processcell motility
C0051492biological_processregulation of stress fiber assembly
C0051893biological_processregulation of focal adhesion assembly
C0070062cellular_componentextracellular exosome
C0070527biological_processplatelet aggregation
C0071346biological_processcellular response to type II interferon
C0072562cellular_componentblood microparticle
C0090303biological_processpositive regulation of wound healing
C0097433cellular_componentdense body
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
C0098974biological_processpostsynaptic actin cytoskeleton organization
C0120192biological_processtight junction assembly
C0120220cellular_componentbasal body patch
C0150111biological_processregulation of transepithelial transport
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902396biological_processprotein localization to bicellular tight junction
D0001525biological_processangiogenesis
D0001738biological_processmorphogenesis of a polarized epithelium
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005522molecular_functionprofilin binding
D0005524molecular_functionATP binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0007409biological_processaxonogenesis
D0010628biological_processpositive regulation of gene expression
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0019901molecular_functionprotein kinase binding
D0030016cellular_componentmyofibril
D0030335biological_processpositive regulation of cell migration
D0030424cellular_componentaxon
D0031625molecular_functionubiquitin protein ligase binding
D0031941cellular_componentfilamentous actin
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0035633biological_processmaintenance of blood-brain barrier
D0042802molecular_functionidentical protein binding
D0043296cellular_componentapical junction complex
D0044305cellular_componentcalyx of Held
D0045177cellular_componentapical part of cell
D0045202cellular_componentsynapse
D0045214biological_processsarcomere organization
D0045335cellular_componentphagocytic vesicle
D0048870biological_processcell motility
D0051492biological_processregulation of stress fiber assembly
D0051893biological_processregulation of focal adhesion assembly
D0070062cellular_componentextracellular exosome
D0070527biological_processplatelet aggregation
D0071346biological_processcellular response to type II interferon
D0072562cellular_componentblood microparticle
D0090303biological_processpositive regulation of wound healing
D0097433cellular_componentdense body
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
D0098974biological_processpostsynaptic actin cytoskeleton organization
D0120192biological_processtight junction assembly
D0120220cellular_componentbasal body patch
D0150111biological_processregulation of transepithelial transport
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902396biological_processprotein localization to bicellular tight junction
E0001525biological_processangiogenesis
E0001738biological_processmorphogenesis of a polarized epithelium
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005522molecular_functionprofilin binding
E0005524molecular_functionATP binding
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005884cellular_componentactin filament
E0005886cellular_componentplasma membrane
E0005911cellular_componentcell-cell junction
E0005925cellular_componentfocal adhesion
E0007409biological_processaxonogenesis
E0010628biological_processpositive regulation of gene expression
E0015629cellular_componentactin cytoskeleton
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0019901molecular_functionprotein kinase binding
E0030016cellular_componentmyofibril
E0030335biological_processpositive regulation of cell migration
E0030424cellular_componentaxon
E0031625molecular_functionubiquitin protein ligase binding
E0031941cellular_componentfilamentous actin
E0035267cellular_componentNuA4 histone acetyltransferase complex
E0035633biological_processmaintenance of blood-brain barrier
E0042802molecular_functionidentical protein binding
E0043296cellular_componentapical junction complex
E0044305cellular_componentcalyx of Held
E0045177cellular_componentapical part of cell
E0045202cellular_componentsynapse
E0045214biological_processsarcomere organization
E0045335cellular_componentphagocytic vesicle
E0048870biological_processcell motility
E0051492biological_processregulation of stress fiber assembly
E0051893biological_processregulation of focal adhesion assembly
E0070062cellular_componentextracellular exosome
E0070527biological_processplatelet aggregation
E0071346biological_processcellular response to type II interferon
E0072562cellular_componentblood microparticle
E0090303biological_processpositive regulation of wound healing
E0097433cellular_componentdense body
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
E0098974biological_processpostsynaptic actin cytoskeleton organization
E0120192biological_processtight junction assembly
E0120220cellular_componentbasal body patch
E0150111biological_processregulation of transepithelial transport
E1900242biological_processregulation of synaptic vesicle endocytosis
E1902396biological_processprotein localization to bicellular tight junction
Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR52-GLY62

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
ATRP355-GLU363

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU103-ARG115

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsMOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:O70468
ChainResidueDetails
MMET0
NMET0
OMET0
PMET0
QMET0
HHIS210
HGLU223
HHIS225
IGLN208
IHIS210
IGLU223
IHIS225
JGLN208
JHIS210
JGLU223
JHIS225
KGLN208
KHIS210
KGLU223
KHIS225
LGLN208
LHIS210
LGLU223
LHIS225

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70468
ChainResidueDetails
MSER46
NSER46
OSER46
PSER46
QSER46

site_idSWS_FT_FI3
Number of Residues10
DetailsMOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P63260
ChainResidueDetails
AMET43
AMET46
BMET43
BMET46
CMET43
CMET46
DMET43
DMET46
EMET43
EMET46

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:30626964, ECO:0000269|Ref.8
ChainResidueDetails
AHIS72
BHIS72
CHIS72
DHIS72
EHIS72

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: N6-methyllysine => ECO:0000269|PubMed:23673617
ChainResidueDetails
ALYS83
BLYS83
CLYS83
DLYS83
ELYS83

site_idSWS_FT_FI6
Number of Residues5
DetailsCROSSLNK: (Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG1 => ECO:0000305|PubMed:19015515
ChainResidueDetails
ALYS49
BLYS49
CLYS49
DLYS49
ELYS49

site_idSWS_FT_FI7
Number of Residues10
DetailsCROSSLNK: (Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1 => ECO:0000305|PubMed:19015515
ChainResidueDetails
CGLU269
DGLU269
EGLU269
AGLU269
BGLU269

221051

PDB entries from 2024-06-12

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