6C45

Crystal structure of human inorganic pyrophosphatase in the P212121 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004427	molecular_function	inorganic diphosphate phosphatase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0016462	molecular_function	pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
B	0000287	molecular_function	magnesium ion binding
B	0004427	molecular_function	inorganic diphosphate phosphatase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0016462	molecular_function	pyrophosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
C	0000287	molecular_function	magnesium ion binding
C	0004427	molecular_function	inorganic diphosphate phosphatase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0016462	molecular_function	pyrophosphatase activity
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
D	0000287	molecular_function	magnesium ion binding
D	0004427	molecular_function	inorganic diphosphate phosphatase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0016462	molecular_function	pyrophosphatase activity
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DNDPIDV

Chain	Residue	Details
A	ASP116-VAL122

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	ASP153
D	ASP116
D	ASP121
D	ASP153
A	ASP116
A	ASP121
A	ASP153
B	ASP116
B	ASP121
B	ASP153
C	ASP116
C	ASP121

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2

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site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS57
C	LYS228
D	LYS57
D	LYS228
A	LYS57
A	LYS228
B	LYS57
B	LYS228

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER250
B	SER250
C	SER250
D	SER250

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