Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6C2G

Human triosephosphate isomerase mutant V231M

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0008929	molecular_function	methylglyoxal synthase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0019242	biological_process	methylglyoxal biosynthetic process
A	0019563	biological_process	glycerol catabolic process
A	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0042803	molecular_function	protein homodimerization activity
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
A	0061621	biological_process	canonical glycolysis
A	0070062	cellular_component	extracellular exosome
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0008929	molecular_function	methylglyoxal synthase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0019242	biological_process	methylglyoxal biosynthetic process
B	0019563	biological_process	glycerol catabolic process
B	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0042803	molecular_function	protein homodimerization activity
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0061621	biological_process	canonical glycolysis
B	0070062	cellular_component	extracellular exosome
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0008929	molecular_function	methylglyoxal synthase activity
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0019242	biological_process	methylglyoxal biosynthetic process
C	0019563	biological_process	glycerol catabolic process
C	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0042803	molecular_function	protein homodimerization activity
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0061621	biological_process	canonical glycolysis
C	0070062	cellular_component	extracellular exosome
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0008929	molecular_function	methylglyoxal synthase activity
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0019242	biological_process	methylglyoxal biosynthetic process
D	0019563	biological_process	glycerol catabolic process
D	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0042803	molecular_function	protein homodimerization activity
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0061621	biological_process	canonical glycolysis
D	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG

Chain	Residue	Details
A	ALA163-GLY173

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Electrophile => ECO:0000255\|PROSITE-ProRule:PRU10127, ECO:0000269\|PubMed:8061610

Chain	Residue	Details
A	LYS58
B	LYS58
C	LYS58
D	LYS58

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10127, ECO:0000269\|PubMed:8061610

Chain	Residue	Details
A	GLY128
B	GLY128
C	GLY128
D	GLY128

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	ALA30
A	GLY171
B	ALA30
B	GLY171
C	ALA30
C	GLY171
D	ALA30
D	GLY171

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	ALA42
B	ALA42
C	ALA42
D	ALA42

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P48500

Chain	Residue	Details
A	LYS68
A	VAL160
B	LYS68
B	VAL160
C	LYS68
C	VAL160
D	LYS68
D	VAL160

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	GLN111
B	GLN111
C	GLN111
D	GLN111

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	ALA118
A	ASP156
B	ALA118
B	ASP156
C	ALA118
C	ASP156
D	ALA118
D	ASP156

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	LEU121
B	LEU121
C	LEU121
D	LEU121

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	GLU135
B	GLU135
C	GLU135
D	GLU135

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	LYS174
B	LYS174
C	LYS174
D	LYS174

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	ALA176
B	ALA176
C	ALA176
D	ALA176

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	HIS185
B	HIS185
C	HIS185
D	HIS185

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	VAL200
B	VAL200
C	VAL200
D	VAL200

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744\|PubMed:25114211

Chain	Residue	Details
A	GLU104
B	GLU104
C	GLU104
D	GLU104

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)