Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue K5A A 601 |
| Chain | Residue |
| A | LYS101 |
| A | LEU234 |
| A | HIS235 |
| A | PRO236 |
| A | TYR318 |
| A | HOH797 |
| A | HOH819 |
| A | HOH915 |
| B | PRO95 |
| B | GLU138 |
| A | ASN103 |
| A | LYS104 |
| A | VAL106 |
| A | VAL179 |
| A | TYR181 |
| A | TYR188 |
| A | PHE227 |
| A | TRP229 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | ASP443 |
| A | ASP498 |
| A | ASP549 |
| A | HOH716 |
| A | HOH873 |
| A | HOH972 |
| A | HOH983 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 603 |
| Chain | Residue |
| A | PRO243 |
| A | ILE244 |
| A | TYR271 |
| A | LEU310 |
| A | GLU312 |
| A | PRO313 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | LYS104 |
| B | PRO97 |
| B | ALA98 |
| B | GLY99 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | LYS73 |
| A | TYR146 |
| A | PRO150 |
| A | GLN151 |
| A | HOH803 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | LYS331 |
| A | GLY333 |
| A | GLN334 |
| A | LYS512 |
| A | HOH841 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 607 |
| Chain | Residue |
| A | LYS476 |
| A | SER515 |
| A | GLU516 |
| A | LEU517 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 608 |
| Chain | Residue |
| A | TYR427 |
| A | GLN428 |
| A | LEU525 |
| A | LYS528 |
| A | GLU529 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | GLU6 |
| A | LYS166 |
| A | HOH943 |
| A | HOH964 |
| B | LYS49 |
| B | ILE50 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | LYS166 |
| A | PRO170 |
| A | TRP212 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| A | ARG463 |
| A | ASP488 |
| A | SER489 |
| A | GLY490 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 612 |
| Chain | Residue |
| A | THR473 |
| A | ASN474 |
| A | GLN475 |
| A | HOH864 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | SER268 |
| A | TYR339 |
| A | GLY352 |
| A | LYS353 |
| A | LYS374 |
| A | HOH1025 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 614 |
| Chain | Residue |
| A | LEU425 |
| A | TRP426 |
| A | TYR427 |
| A | GLN509 |
| A | HOH875 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 615 |
| Chain | Residue |
| A | LEU486 |
| A | SER489 |
| A | GLN524 |
| A | LYS528 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 616 |
| Chain | Residue |
| A | TRP88 |
| B | LYS20 |
| B | LYS22 |
| B | HOH622 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 617 |
| Chain | Residue |
| A | GLU404 |
| A | TYR405 |
| A | TRP406 |
| A | GLN507 |
| A | GLN509 |
| B | LYS424 |
| B | SO4503 |
| B | HOH746 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 618 |
| Chain | Residue |
| A | TRP153 |
| A | PRO157 |
| A | GLY152 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 619 |
| Chain | Residue |
| A | TRP426 |
| A | ASP511 |
| A | LYS512 |
| A | GLU523 |
| A | HOH708 |
| A | HOH767 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 620 |
| Chain | Residue |
| A | ARG277 |
| A | LYS281 |
| A | GLN334 |
| A | ARG356 |
| A | HOH727 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 621 |
| Chain | Residue |
| A | PRO272 |
| A | GLN330 |
| A | THR338 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 622 |
| Chain | Residue |
| A | LYS101 |
| A | TYR319 |
| A | PRO321 |
| A | HOH801 |
| B | GLU28 |
| B | ILE135 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 623 |
| Chain | Residue |
| A | LEU429 |
| A | GLU430 |
| A | LYS431 |
| A | GLN507 |
| A | HOH951 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 624 |
| Chain | Residue |
| A | LEU26 |
| A | GLU28 |
| A | ILE31 |
| A | ILE135 |
| A | ASN136 |
| A | HOH711 |
| A | HOH798 |
| B | LYS390 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue DMS B 501 |
| Chain | Residue |
| A | ILE380 |
| B | THR27 |
| B | THR400 |
| B | TRP401 |
| B | THR403 |
| B | GLU404 |
| B | EDO520 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | TYR56 |
| B | LYS126 |
| B | HOH677 |
| B | HOH783 |
| B | HOH794 |
| B | HOH809 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| A | THR403 |
| A | GLU404 |
| A | TYR405 |
| A | EDO617 |
| B | LYS331 |
| B | GLN332 |
| B | LYS424 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| A | GLU138 |
| A | GLN500 |
| A | TRP535 |
| B | GLN269 |
| B | LEU422 |
| B | TRP426 |
| B | HOH696 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | LYS275 |
| B | VAL276 |
| B | ARG277 |
| B | HOH788 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 506 |
| Chain | Residue |
| B | LEU234 |
| B | HIS235 |
| B | TRP239 |
| B | HOH780 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | GLU328 |
| B | ILE329 |
| B | GLN330 |
| B | LYS390 |
| B | PRO392 |
| B | PRO421 |
| B | HOH678 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | VAL75 |
| B | PHE77 |
| B | ASN81 |
| B | GLY152 |
| B | ILE411 |
| B | HOH810 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | TYR183 |
| B | LYS385 |
| B | THR386 |
| B | HOH772 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | TRP24 |
| B | GLU399 |
| B | TRP402 |
| B | THR403 |
| B | EDO520 |
| B | HOH642 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | TYR339 |
| B | GLY352 |
| B | LYS353 |
| B | TYR354 |
| B | HOH613 |
| B | HOH751 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| B | GLU370 |
| B | LYS374 |
| B | HOH791 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 513 |
| Chain | Residue |
| A | ALA534 |
| A | TRP535 |
| A | HOH802 |
| A | HOH882 |
| A | HOH996 |
| B | ASN255 |
| B | GLN258 |
| B | LYS259 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 514 |
| Chain | Residue |
| B | PRO133 |
| B | SER134 |
| B | ASN137 |
| B | GLY141 |
| B | HOH676 |
| B | HOH689 |
| B | HOH806 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 515 |
| Chain | Residue |
| B | ILE244 |
| B | VAL245 |
| B | LYS263 |
| B | TRP266 |
| B | TRP426 |
| B | HOH775 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 516 |
| Chain | Residue |
| B | THR290 |
| B | GLU291 |
| B | VAL292 |
| B | HOH614 |
| B | HOH807 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 517 |
| Chain | Residue |
| B | PRO157 |
| B | GLN182 |
| B | TYR183 |
| B | MET184 |
| B | HOH675 |
| site_id | AG6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 518 |
| Chain | Residue |
| A | TRP410 |
| B | GLU248 |
| B | LYS249 |
| B | ARG307 |
| B | THR362 |
| B | HOH625 |
| B | HOH647 |
| B | HOH737 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 519 |
| Chain | Residue |
| B | LYS65 |
| B | ASP186 |
| B | ALA408 |
| B | THR409 |
| B | TRP410 |
| B | HOH636 |
| site_id | AG8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 520 |
| Chain | Residue |
| A | THR377 |
| B | GLU399 |
| B | THR400 |
| B | DMS501 |
| B | EDO510 |
| B | HOH727 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASP110 | |
| B | ASP185 | |
| B | ASP186 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| B | TRP401 | |
| B | TRP414 | |
| A | ASP498 | |
| A | ASP549 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| A | TRP401 | |
| A | TRP414 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by viral protease; partial |
| Chain | Residue | Details |
| A | PHE440 | |
