6BR2
Structure of RORgt in complex with a novel isoquinoline inverse agonist.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 501 |
| Chain | Residue |
| A | GLU304 |
| A | TYR308 |
| A | LYS311 |
| A | ARG319 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue E3S A 502 |
| Chain | Residue |
| A | MET365 |
| A | PHE377 |
| A | PHE378 |
| A | GLU379 |
| A | GLY380 |
| A | PHE388 |
| A | GLN286 |
| A | CYS320 |
| A | HIS323 |
| A | LEU324 |
| A | ARG364 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MPD B 501 |
| Chain | Residue |
| B | GLU290 |
| B | GLU304 |
| B | GLY307 |
| B | TYR308 |
| B | LYS311 |
| B | ARG319 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue E3S B 502 |
| Chain | Residue |
| B | GLN286 |
| B | CYS320 |
| B | HIS323 |
| B | LEU324 |
| B | ARG364 |
| B | PHE377 |
| B | PHE378 |
| B | GLU379 |
| B | GLY380 |
| B | PHE388 |
