6BA4
Crystal structure of MYST acetyltransferase domain in complex with Acetyl-CoA cofactor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | CYS540 |
| A | CYS543 |
| A | HIS556 |
| A | CYS560 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 802 |
| Chain | Residue |
| A | ASP520 |
| A | NA803 |
| A | NA804 |
| A | HOH1028 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 803 |
| Chain | Residue |
| A | TRP522 |
| A | TYR549 |
| A | NA802 |
| A | ASP520 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 804 |
| Chain | Residue |
| A | ASP520 |
| A | MET547 |
| A | LYS548 |
| A | SER552 |
| A | NA802 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | binding site for residue ACO A 805 |
| Chain | Residue |
| A | PHE600 |
| A | LEU601 |
| A | SER645 |
| A | CYS646 |
| A | ILE647 |
| A | MET648 |
| A | ILE649 |
| A | GLN654 |
| A | ARG655 |
| A | ARG656 |
| A | GLY657 |
| A | GLY659 |
| A | ARG660 |
| A | GLU680 |
| A | SER684 |
| A | LEU686 |
| A | SER690 |
| A | SER693 |
| A | GLN760 |
| A | 7L1806 |
| A | HOH901 |
| A | HOH902 |
| A | HOH907 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | binding site for residue 7L1 A 806 |
| Chain | Residue |
| A | PHE600 |
| A | LEU601 |
| A | SER645 |
| A | CYS646 |
| A | ILE647 |
| A | MET648 |
| A | ILE649 |
| A | GLN654 |
| A | ARG655 |
| A | ARG656 |
| A | GLY657 |
| A | GLY659 |
| A | ARG660 |
| A | PRO679 |
| A | GLU680 |
| A | LEU683 |
| A | SER684 |
| A | LEU686 |
| A | GLY687 |
| A | SER690 |
| A | SER693 |
| A | ACO805 |
| A | HOH901 |
| A | HOH902 |
| A | HOH907 |
| A | HOH961 |
| A | HOH972 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000269|PubMed:22020126 |
| Chain | Residue | Details |
| A | LEU537-TRP562 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000303|PubMed:21217699, ECO:0000303|PubMed:22020126, ECO:0000305 |
| Chain | Residue | Details |
| A | GLU680 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23 |
| Chain | Residue | Details |
| A | SER693 | |
| A | LYS762 | |
| A | ILE647 | |
| A | GLN654 | |
| A | SER684 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|Ref.23 |
| Chain | Residue | Details |
| A | ALY604 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER678 |
