6B81
Crystal structure of Myotoxin II from Bothrops moojeni complexed to Caprylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0050482 | biological_process | arachidonic acid secretion |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| B | 0050482 | biological_process | arachidonic acid secretion |
| B | 0050832 | biological_process | defense response to fungus |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | LYS16 |
| B | ASN17 |
| B | LYS20 |
| B | HOH305 |
| B | HOH319 |
| B | HOH348 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | ARG118 |
| B | HOH373 |
| B | LYS16 |
| B | LYS20 |
| B | LYS115 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| B | GLY33 |
| B | ARG34 |
| B | LYS53 |
| B | HOH333 |
| B | HOH361 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue OCA B 204 |
| Chain | Residue |
| B | TYR22 |
| B | CYS29 |
| B | GLY30 |
| B | CYS45 |
| B | HIS48 |
| B | LYS49 |
| B | HOH418 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | LYS16 |
| A | LYS20 |
| A | LYS115 |
| A | ARG118 |
| A | HOH368 |
| A | HOH394 |
| A | HOH402 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | LYS16 |
| A | ASN17 |
| A | LYS20 |
| A | HOH303 |
| A | HOH332 |
| A | HOH364 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | ARG34 |
| A | LYS53 |
| A | HOH313 |
| A | HOH397 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue OCA A 204 |
| Chain | Residue |
| A | LEU2 |
| A | PRO18 |
| A | TYR22 |
| A | ASN28 |
| A | CYS29 |
| A | GLY30 |
| A | HIS48 |
| A | LYS49 |
| B | TYR121 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000305|PubMed:29287778 |
| Chain | Residue | Details |
| B | LYS16 | |
| B | LYS20 | |
| A | LYS16 | |
| A | LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6, ECO:0000305|PubMed:29287778 |
| Chain | Residue | Details |
| B | LYS115 | |
| B | ARG118 | |
| A | LYS115 | |
| A | ARG118 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| B | LEU122 | |
| B | PHE126 | |
| A | LEU122 | |
| A | PHE126 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| B | LYS123 | |
| B | LYS129 | |
| A | LYS123 | |
| A | LYS129 |
