6AQ1
The crystal structure of human FABP3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015909 | biological_process | long-chain fatty acid transport |
| A | 0032365 | biological_process | intracellular lipid transport |
| A | 0036041 | molecular_function | long-chain fatty acid binding |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0046320 | biological_process | regulation of fatty acid oxidation |
| A | 0050873 | biological_process | brown fat cell differentiation |
| A | 0055091 | biological_process | phospholipid homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070538 | molecular_function | oleic acid binding |
| A | 0071073 | biological_process | positive regulation of phospholipid biosynthetic process |
| A | 0140214 | biological_process | positive regulation of long-chain fatty acid import into cell |
| A | 2001245 | biological_process | regulation of phosphatidylcholine biosynthetic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008092 | molecular_function | cytoskeletal protein binding |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015909 | biological_process | long-chain fatty acid transport |
| B | 0032365 | biological_process | intracellular lipid transport |
| B | 0036041 | molecular_function | long-chain fatty acid binding |
| B | 0042632 | biological_process | cholesterol homeostasis |
| B | 0046320 | biological_process | regulation of fatty acid oxidation |
| B | 0050873 | biological_process | brown fat cell differentiation |
| B | 0055091 | biological_process | phospholipid homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070538 | molecular_function | oleic acid binding |
| B | 0071073 | biological_process | positive regulation of phospholipid biosynthetic process |
| B | 0140214 | biological_process | positive regulation of long-chain fatty acid import into cell |
| B | 2001245 | biological_process | regulation of phosphatidylcholine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | SER14 |
| B | ASP78 |
| A | LYS15 |
| A | ASN16 |
| A | PHE17 |
| A | ASP18 |
| A | HOH352 |
| A | HOH412 |
| A | HOH428 |
| B | LYS59 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PLM A 202 |
| Chain | Residue |
| A | MET21 |
| A | LEU116 |
| A | ARG127 |
| A | TYR129 |
| A | HOH311 |
| A | HOH334 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | SER14 |
| B | LYS15 |
| B | ASN16 |
| B | PHE17 |
| B | ASP18 |
| B | SER35 |
| B | HOH313 |
| B | HOH330 |
| B | HOH368 |
| B | HOH393 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | GLY27 |
| B | PHE28 |
| B | ARG31 |
| B | HOH358 |
| B | HOH420 |
| B | HOH424 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| A | LYS113 |
| B | LYS53 |
| B | HIS55 |
| B | HOH305 |
| B | HOH306 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue PLM B 204 |
| Chain | Residue |
| B | THR37 |
| B | THR54 |
| B | SER56 |
| B | PHE58 |
| B | ASP77 |
| B | LEU116 |
| B | ARG127 |
| B | TYR129 |
| B | HOH322 |
| B | HOH345 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GTWkLvdSkNFDdYMKSL |
| Chain | Residue | Details |
| A | GLY7-LEU24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:7922029, ECO:0007744|PDB:1HMT |
| Chain | Residue | Details |
| B | ARG127 | |
| A | ARG127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylvaline => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | VAL2 | |
| B | VAL2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07483 |
| Chain | Residue | Details |
| B | THR8 | |
| B | THR30 | |
| A | THR8 | |
| A | THR30 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000250|UniProtKB:P07483 |
| Chain | Residue | Details |
| B | TYR20 | |
| A | TYR20 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07483 |
| Chain | Residue | Details |
| A | SER23 | |
| A | SER83 | |
| B | SER23 | |
| B | SER83 |
