Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004013 | molecular_function | adenosylhomocysteinase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0033353 | biological_process | S-adenosylmethionine cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | binding site for residue NAD A 500 |
Chain | Residue |
A | THR162 |
A | GLU248 |
A | ILE249 |
A | ASP250 |
A | CYS253 |
A | THR280 |
A | THR281 |
A | GLY282 |
A | ASN283 |
A | ILE286 |
A | ILE304 |
A | THR163 |
A | GLY305 |
A | HIS306 |
A | ASN351 |
A | HIS358 |
A | LYS431 |
A | TYR435 |
A | ADN501 |
A | HOH640 |
A | HOH656 |
A | HOH687 |
A | THR164 |
A | HOH760 |
A | HOH838 |
A | HOH887 |
A | ASN196 |
A | GLY225 |
A | GLY227 |
A | ASP228 |
A | VAL229 |
A | THR247 |
site_id | AC2 |
Number of Residues | 16 |
Details | binding site for residue ADN A 501 |
Chain | Residue |
A | LEU57 |
A | HIS58 |
A | THR60 |
A | GLN62 |
A | THR63 |
A | ASP136 |
A | GLU161 |
A | THR162 |
A | LYS191 |
A | ASP195 |
A | HIS306 |
A | THR356 |
A | GLY357 |
A | HIS358 |
A | MET363 |
A | NAD500 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue MPD A 502 |
Chain | Residue |
A | GLU417 |
A | GLU417 |
A | LYS420 |
A | LYS420 |
Functional Information from PROSITE/UniProt
site_id | PS00738 |
Number of Residues | 15 |
Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDhAAAAI |
Chain | Residue | Details |
A | SER81-ILE95 | |
site_id | PS00739 |
Number of Residues | 18 |
Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKrvvVcGFGdVGKGtaA |
Chain | Residue | Details |
A | GLY218-ALA235 | |