5ZZ1
Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0020037 | molecular_function | heme binding |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004096 | molecular_function | catalase activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0020037 | molecular_function | heme binding |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004096 | molecular_function | catalase activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0020037 | molecular_function | heme binding |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue HDD A 701 |
| Chain | Residue |
| A | ARG79 |
| A | PHE168 |
| A | HIS229 |
| A | PHE345 |
| A | LEU361 |
| A | ARG365 |
| A | SER368 |
| A | TYR369 |
| A | THR372 |
| A | GLN373 |
| A | ARG376 |
| A | VAL81 |
| A | HOH803 |
| A | HOH829 |
| A | HOH891 |
| A | HOH937 |
| A | HIS82 |
| A | ARG119 |
| A | GLY138 |
| A | VAL153 |
| A | GLY154 |
| A | ASN155 |
| A | PHE160 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 3TR A 702 |
| Chain | Residue |
| A | PRO158 |
| A | PHE226 |
| A | HIS246 |
| A | ILE313 |
| A | ILE314 |
| A | GLU316 |
| A | HOH814 |
| A | HOH847 |
| A | HOH878 |
| A | HOH1143 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 3TR A 703 |
| Chain | Residue |
| A | SER597 |
| A | PRO624 |
| A | LEU625 |
| A | PHE626 |
| A | PRO627 |
| A | HOH819 |
| A | HOH936 |
| A | HOH949 |
| A | HOH1156 |
| C | GLU259 |
| C | ASN479 |
| C | HOH817 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 704 |
| Chain | Residue |
| A | HIS190 |
| A | ASP191 |
| A | SER192 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 1701 |
| Chain | Residue |
| B | HOH1896 |
| B | HOH2194 |
| D | HOH821 |
| D | HOH1178 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | binding site for residue HDD B 1702 |
| Chain | Residue |
| B | ARG79 |
| B | VAL81 |
| B | HIS82 |
| B | ARG119 |
| B | GLY138 |
| B | VAL153 |
| B | GLY154 |
| B | ASN155 |
| B | PHE160 |
| B | PHE168 |
| B | HIS229 |
| B | PHE345 |
| B | LEU361 |
| B | ARG365 |
| B | SER368 |
| B | TYR369 |
| B | THR372 |
| B | GLN373 |
| B | ARG376 |
| B | HOH1894 |
| B | HOH1926 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue 3TR B 1703 |
| Chain | Residue |
| B | PRO158 |
| B | HIS246 |
| B | ILE313 |
| B | ILE314 |
| B | GLU316 |
| B | HOH1814 |
| B | HOH1887 |
| B | HOH2019 |
| B | HOH2094 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue 3TR B 1704 |
| Chain | Residue |
| B | SER597 |
| B | PRO624 |
| B | LEU625 |
| B | PHE626 |
| B | PRO627 |
| B | HOH1842 |
| B | HOH1967 |
| B | HOH2126 |
| B | HOH2175 |
| D | GLU259 |
| D | ASN479 |
| D | HOH813 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 1705 |
| Chain | Residue |
| B | HIS190 |
| B | ASP191 |
| B | SER192 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue 3TR B 1706 |
| Chain | Residue |
| B | HOH1804 |
| B | HOH2106 |
| B | HOH2148 |
| B | HOH2157 |
| D | PRO624 |
| D | LEU625 |
| D | PHE626 |
| D | PRO627 |
| D | HOH859 |
| D | HOH927 |
| B | GLU259 |
| B | ASN479 |
| site_id | AD2 |
| Number of Residues | 23 |
| Details | binding site for residue HDD C 701 |
| Chain | Residue |
| C | ARG79 |
| C | VAL81 |
| C | HIS82 |
| C | ARG119 |
| C | GLY138 |
| C | VAL153 |
| C | GLY154 |
| C | ASN155 |
| C | PHE160 |
| C | PHE168 |
| C | VAL228 |
| C | HIS229 |
| C | PHE345 |
| C | LEU361 |
| C | ARG365 |
| C | SER368 |
| C | TYR369 |
| C | THR372 |
| C | GLN373 |
| C | ARG376 |
| C | HOH912 |
| C | HOH960 |
| C | HOH1185 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue 3TR C 702 |
| Chain | Residue |
| C | PRO158 |
| C | HIS246 |
| C | ILE314 |
| C | GLU316 |
| C | HOH820 |
| C | HOH852 |
| C | HOH997 |
| C | HOH1112 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue 3TR C 703 |
| Chain | Residue |
| A | GLU259 |
| A | ASN479 |
| A | HOH807 |
| C | SER597 |
| C | PRO624 |
| C | LEU625 |
| C | PHE626 |
| C | PRO627 |
| C | HOH882 |
| C | HOH1071 |
| C | HOH1161 |
| C | HOH1175 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CA C 704 |
| Chain | Residue |
| C | HIS190 |
| C | ASP191 |
| C | SER192 |
| site_id | AD6 |
| Number of Residues | 23 |
| Details | binding site for residue HDD D 701 |
| Chain | Residue |
| D | ARG79 |
| D | VAL81 |
| D | HIS82 |
| D | ARG119 |
| D | GLY138 |
| D | VAL153 |
| D | GLY154 |
| D | ASN155 |
| D | PHE160 |
| D | PHE168 |
| D | VAL228 |
| D | HIS229 |
| D | PHE345 |
| D | LEU361 |
| D | ARG365 |
| D | SER368 |
| D | TYR369 |
| D | THR372 |
| D | GLN373 |
| D | ARG376 |
| D | HOH849 |
| D | HOH1029 |
| D | HOH1145 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue 3TR D 702 |
| Chain | Residue |
| D | PRO158 |
| D | HIS246 |
| D | ILE313 |
| D | ILE314 |
| D | GLU316 |
| D | HOH812 |
| D | HOH862 |
| D | HOH865 |
| D | HOH1120 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CA D 703 |
| Chain | Residue |
| C | HOH1088 |
| D | HIS190 |
| D | ASP191 |
| D | SER192 |
Functional Information from PROSITE/UniProt
| site_id | PS00437 |
| Number of Residues | 9 |
| Details | CATALASE_1 Catalase proximal heme-ligand signature. RLFSYlDTQ |
| Chain | Residue | Details |
| A | ARG365-GLN373 |
| site_id | PS00438 |
| Number of Residues | 17 |
| Details | CATALASE_2 Catalase proximal active site signature. FdHervpERavHarGAG |
| Chain | Residue | Details |
| A | PHE71-GLY87 |
| site_id | PS00674 |
| Number of Residues | 20 |
| Details | AAA AAA-protein family signature. VgILaTTSessaLDqAAqlR |
| Chain | Residue | Details |
| A | VAL552-ARG571 |
