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5YZ0

Cryo-EM Structure of human ATR-ATRIP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005794cellular_componentGolgi apparatus
A0006139biological_processnucleobase-containing compound metabolic process
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006338biological_processchromatin remodeling
A0006974biological_processDNA damage response
A0008156biological_processnegative regulation of DNA replication
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0018105biological_processpeptidyl-serine phosphorylation
A0031297biological_processreplication fork processing
A0032212biological_processpositive regulation of telomere maintenance via telomerase
A0032405molecular_functionMutLalpha complex binding
A0032407molecular_functionMutSalpha complex binding
A0034644biological_processcellular response to UV
A0035979molecular_functionhistone H2AXS139 kinase activity
A0036297biological_processinterstrand cross-link repair
A0043517biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator
A0044818biological_processmitotic G2/M transition checkpoint
A0046685biological_processresponse to arsenic-containing substance
A0046777biological_processprotein autophosphorylation
A0051081biological_processnuclear membrane disassembly
A0051171biological_processobsolete regulation of nitrogen compound metabolic process
A0070198biological_processprotein localization to chromosome, telomeric region
A0070310cellular_componentATR-ATRIP complex
A0071480biological_processcellular response to gamma radiation
A0080090biological_processregulation of primary metabolic process
A0080135biological_processregulation of cellular response to stress
A0090399biological_processreplicative senescence
A0090734cellular_componentsite of DNA damage
A0097694biological_processestablishment of RNA localization to telomere
A0097695biological_processestablishment of protein-containing complex localization to telomere
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1904884biological_processpositive regulation of telomerase catalytic core complex assembly
A2000779biological_processregulation of double-strand break repair
B0000077biological_processDNA damage checkpoint signaling
B0000723biological_processtelomere maintenance
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005794cellular_componentGolgi apparatus
B0006139biological_processnucleobase-containing compound metabolic process
B0006260biological_processDNA replication
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006338biological_processchromatin remodeling
B0006974biological_processDNA damage response
B0008156biological_processnegative regulation of DNA replication
B0009410biological_processresponse to xenobiotic stimulus
B0009612biological_processresponse to mechanical stimulus
B0016301molecular_functionkinase activity
B0016605cellular_componentPML body
B0018105biological_processpeptidyl-serine phosphorylation
B0031297biological_processreplication fork processing
B0032212biological_processpositive regulation of telomere maintenance via telomerase
B0032405molecular_functionMutLalpha complex binding
B0032407molecular_functionMutSalpha complex binding
B0034644biological_processcellular response to UV
B0035979molecular_functionhistone H2AXS139 kinase activity
B0036297biological_processinterstrand cross-link repair
B0043517biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator
B0044818biological_processmitotic G2/M transition checkpoint
B0046685biological_processresponse to arsenic-containing substance
B0046777biological_processprotein autophosphorylation
B0051081biological_processnuclear membrane disassembly
B0051171biological_processobsolete regulation of nitrogen compound metabolic process
B0070198biological_processprotein localization to chromosome, telomeric region
B0070310cellular_componentATR-ATRIP complex
B0071480biological_processcellular response to gamma radiation
B0080090biological_processregulation of primary metabolic process
B0080135biological_processregulation of cellular response to stress
B0090399biological_processreplicative senescence
B0090734cellular_componentsite of DNA damage
B0097694biological_processestablishment of RNA localization to telomere
B0097695biological_processestablishment of protein-containing complex localization to telomere
B0106310molecular_functionprotein serine kinase activity
B1900034biological_processregulation of cellular response to heat
B1904884biological_processpositive regulation of telomerase catalytic core complex assembly
B2000779biological_processregulation of double-strand break repair
C0000077biological_processDNA damage checkpoint signaling
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006139biological_processnucleobase-containing compound metabolic process
C0006281biological_processDNA repair
C0070310cellular_componentATR-ATRIP complex
C0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
C2000779biological_processregulation of double-strand break repair
D0000077biological_processDNA damage checkpoint signaling
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0006139biological_processnucleobase-containing compound metabolic process
D0006281biological_processDNA repair
D0070310cellular_componentATR-ATRIP complex
D0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
D2000779biological_processregulation of double-strand break repair
Functional Information from PROSITE/UniProt
site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. StAvmsMvgYILgLgDRHgeN
ChainResidueDetails
ASER2460-ASN2480

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER428
BSER428

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:21777809, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER435
ASER435

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER436
BSER436

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:21705319, ECO:0000269|PubMed:21777809, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR1989
BTHR1989

220472

PDB entries from 2024-05-29

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