5YU7

CRYSTAL STRUCTURE OF EXPORTIN-5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006405	biological_process	RNA export from nucleus
A	0006611	biological_process	protein export from nucleus
A	0006886	biological_process	intracellular protein transport
A	0010586	biological_process	miRNA metabolic process
A	0015031	biological_process	protein transport
A	0016442	cellular_component	RISC complex
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0031267	molecular_function	small GTPase binding
A	0035281	biological_process	pre-miRNA export from nucleus
A	0042565	cellular_component	RNA nuclear export complex
A	0070883	molecular_function	pre-miRNA binding
A	1905172	molecular_function	RISC complex binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Pre-miRNA binding => ECO:0000269|PubMed:19965479

Chain	Residue	Details
A	ALA441
A	ARG448
A	ARG718
A	GLN1045

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	ALA2

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS396

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
A	SER826

---