5YCR
X-Ray Structure of Enoyl-Acyl Carrier Protein Reductase from Bacillus Anthracis with NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070401 | molecular_function | NADP+ binding |
| A | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070401 | molecular_function | NADP+ binding |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 1902494 | cellular_component | catalytic complex |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0030497 | biological_process | fatty acid elongation |
| C | 0036094 | molecular_function | small molecule binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0070401 | molecular_function | NADP+ binding |
| C | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 1902494 | cellular_component | catalytic complex |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0030497 | biological_process | fatty acid elongation |
| D | 0036094 | molecular_function | small molecule binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0070401 | molecular_function | NADP+ binding |
| D | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue NAD A 301 |
| Chain | Residue |
| A | GLY13 |
| A | VAL67 |
| A | CYS93 |
| A | ILE94 |
| A | ALA95 |
| A | LEU145 |
| A | THR146 |
| A | LYS164 |
| A | ALA190 |
| A | LEU196 |
| A | HOH403 |
| A | VAL14 |
| A | HOH404 |
| A | HOH437 |
| A | HOH450 |
| A | HOH471 |
| A | HOH474 |
| A | HOH526 |
| A | ALA15 |
| A | SER19 |
| A | ILE20 |
| A | ALA40 |
| A | LEU44 |
| A | CYS65 |
| A | ASP66 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG26 |
| A | ASN30 |
| A | HOH524 |
| D | ARG26 |
| D | HOH438 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | ARG130 |
| A | LYS134 |
| A | HOH402 |
| A | HOH449 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | ARG130 |
| A | HOH405 |
| A | HOH513 |
| A | HOH517 |
| C | ASP108 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | HIS247 |
| A | HIS253 |
| A | HOH502 |
| A | HOH519 |
| A | HOH521 |
| B | GLU244 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | ARG239 |
| A | HOH500 |
| B | THR222 |
| B | GLU224 |
| B | HOH428 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | binding site for residue NAD B 301 |
| Chain | Residue |
| B | GLY13 |
| B | VAL14 |
| B | ALA15 |
| B | SER19 |
| B | ILE20 |
| B | ALA40 |
| B | LEU44 |
| B | CYS65 |
| B | ASP66 |
| B | VAL67 |
| B | CYS93 |
| B | ILE94 |
| B | ALA95 |
| B | LEU145 |
| B | THR146 |
| B | TYR147 |
| B | LYS164 |
| B | ALA190 |
| B | LEU196 |
| B | HOH401 |
| B | HOH456 |
| B | HOH464 |
| B | HOH476 |
| B | HOH489 |
| B | HOH496 |
| B | HOH519 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | ARG130 |
| B | LYS134 |
| B | HOH467 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | ARG130 |
| B | HOH402 |
| B | HOH415 |
| D | ASP108 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| A | THR222 |
| A | GLU224 |
| A | HOH416 |
| B | ARG239 |
| D | MET1 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 305 |
| Chain | Residue |
| A | GLU244 |
| B | HIS253 |
| B | HOH412 |
| B | HOH442 |
| B | HOH511 |
| site_id | AD3 |
| Number of Residues | 27 |
| Details | binding site for residue NAD C 301 |
| Chain | Residue |
| C | LEU44 |
| C | CYS65 |
| C | ASP66 |
| C | VAL67 |
| C | THR68 |
| C | CYS93 |
| C | ILE94 |
| C | ALA95 |
| C | LEU145 |
| C | THR146 |
| C | TYR147 |
| C | LYS164 |
| C | ALA190 |
| C | HOH401 |
| C | HOH408 |
| C | HOH411 |
| C | HOH413 |
| C | HOH447 |
| C | HOH482 |
| C | HOH486 |
| C | HOH521 |
| C | GLY13 |
| C | VAL14 |
| C | ALA15 |
| C | SER19 |
| C | ILE20 |
| C | ALA40 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 302 |
| Chain | Residue |
| C | ARG130 |
| C | LYS134 |
| C | HOH426 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 303 |
| Chain | Residue |
| C | HIS253 |
| C | HOH403 |
| C | HOH422 |
| C | HOH473 |
| D | LYS172 |
| D | GLU244 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 304 |
| Chain | Residue |
| C | THR222 |
| C | GLU224 |
| D | ARG239 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 305 |
| Chain | Residue |
| C | ARG239 |
| D | THR222 |
| D | GLU224 |
| site_id | AD8 |
| Number of Residues | 22 |
| Details | binding site for residue NAD D 301 |
| Chain | Residue |
| D | GLY13 |
| D | VAL14 |
| D | ALA15 |
| D | SER19 |
| D | ILE20 |
| D | ALA40 |
| D | LEU44 |
| D | CYS65 |
| D | ASP66 |
| D | VAL67 |
| D | CYS93 |
| D | ILE94 |
| D | ALA95 |
| D | LEU145 |
| D | THR146 |
| D | TYR147 |
| D | LYS164 |
| D | ALA190 |
| D | HOH431 |
| D | HOH435 |
| D | HOH451 |
| D | HOH466 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 302 |
| Chain | Residue |
| D | ARG130 |
| D | LYS134 |
| D | HOH454 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 303 |
| Chain | Residue |
| B | SER110 |
| D | ARG130 |
| D | HOH407 |
| D | HOH426 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR147 | |
| B | TYR147 | |
| C | TYR147 | |
| D | TYR147 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| D | TYR157 | |
| A | TYR157 | |
| B | TYR157 | |
| C | TYR157 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20800575 |
| Chain | Residue | Details |
| A | LYS164 | |
| A | ILE193 | |
| B | GLY13 | |
| B | SER19 | |
| B | ASP66 | |
| B | ILE94 | |
| B | LYS164 | |
| B | ILE193 | |
| C | GLY13 | |
| C | SER19 | |
| C | ASP66 | |
| C | ILE94 | |
| C | LYS164 | |
| C | ILE193 | |
| D | GLY13 | |
| D | SER19 | |
| D | ASP66 | |
| D | ILE94 | |
| D | LYS164 | |
| D | ILE193 | |
| A | ILE94 | |
| A | GLY13 | |
| A | SER19 | |
| A | ASP66 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA97 | |
| B | ALA97 | |
| C | ALA97 | |
| D | ALA97 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Involved in acyl-ACP binding => ECO:0000250 |
| Chain | Residue | Details |
| C | ASN205 | |
| D | ASN205 | |
| A | ASN205 | |
| B | ASN205 |
