5Y31

Crystal structure of human LGI1-ADAM22 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0007399	biological_process	nervous system development
B	0007411	biological_process	axon guidance
B	0030307	biological_process	positive regulation of cell growth
B	0030425	cellular_component	dendrite
B	0031175	biological_process	neuron projection development
B	0043083	cellular_component	synaptic cleft
B	0043194	cellular_component	axon initial segment
B	0045202	cellular_component	synapse
B	0050806	biological_process	positive regulation of synaptic transmission
B	0098978	cellular_component	glutamatergic synapse
B	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0007399	biological_process	nervous system development
D	0007411	biological_process	axon guidance
D	0030307	biological_process	positive regulation of cell growth
D	0030425	cellular_component	dendrite
D	0031175	biological_process	neuron projection development
D	0043083	cellular_component	synaptic cleft
D	0043194	cellular_component	axon initial segment
D	0045202	cellular_component	synapse
D	0050806	biological_process	positive regulation of synaptic transmission
D	0098978	cellular_component	glutamatergic synapse
D	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CvCnrHwiGSdC

Chain	Residue	Details
A	CYS700-CYS711

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site_id	PS00427
Number of Residues	20
Details	DISINTEGRIN_1 Disintegrins signature. CsdGlCCk.KCkFqpmgtvCR

Chain	Residue	Details
A	CYS485-ARG504

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN192
B	ASN277
B	ASN422
D	ASN192
D	ASN277
D	ASN422

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