5XVU
Crystal structure of the protein kinase CK2 catalytic domain from Plasmodium falciparum bound to ATP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005956 | cellular_component | protein kinase CK2 complex |
A | 0006468 | biological_process | protein phosphorylation |
A | 0018105 | biological_process | peptidyl-serine phosphorylation |
A | 0019901 | molecular_function | protein kinase binding |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0046777 | biological_process | protein autophosphorylation |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0106310 | molecular_function | protein serine kinase activity |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005956 | cellular_component | protein kinase CK2 complex |
B | 0006468 | biological_process | protein phosphorylation |
B | 0018105 | biological_process | peptidyl-serine phosphorylation |
B | 0019901 | molecular_function | protein kinase binding |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0046777 | biological_process | protein autophosphorylation |
B | 0051726 | biological_process | regulation of cell cycle |
B | 0106310 | molecular_function | protein serine kinase activity |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004674 | molecular_function | protein serine/threonine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005956 | cellular_component | protein kinase CK2 complex |
C | 0006468 | biological_process | protein phosphorylation |
C | 0018105 | biological_process | peptidyl-serine phosphorylation |
C | 0019901 | molecular_function | protein kinase binding |
C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
C | 0046777 | biological_process | protein autophosphorylation |
C | 0051726 | biological_process | regulation of cell cycle |
C | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 401 |
Chain | Residue |
A | ARG84 |
A | ARG159 |
A | ASN193 |
A | HOH506 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue CL A 402 |
Chain | Residue |
A | ARG199 |
A | ASN242 |
site_id | AC3 |
Number of Residues | 15 |
Details | binding site for residue ATP A 403 |
Chain | Residue |
A | TYR54 |
A | SER55 |
A | VAL57 |
A | ALA70 |
A | LYS72 |
A | LYS81 |
A | ILE99 |
A | GLU118 |
A | ILE120 |
A | HIS164 |
A | SER179 |
B | GLU64 |
A | ILE49 |
A | GLY50 |
A | LYS53 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue EDO A 404 |
Chain | Residue |
A | ASP29 |
A | TYR30 |
A | ASP31 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue EDO A 405 |
Chain | Residue |
A | MET323 |
A | GLU324 |
A | HIS325 |
A | PHE328 |
A | GLU330 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 401 |
Chain | Residue |
B | LYS81 |
B | ARG84 |
B | ARG159 |
B | ASN193 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 402 |
Chain | Residue |
A | ARG51 |
B | ASN38 |
B | LYS39 |
B | HOH508 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue CL B 403 |
Chain | Residue |
B | ARG199 |
B | ASN242 |
site_id | AC9 |
Number of Residues | 16 |
Details | binding site for residue ATP B 404 |
Chain | Residue |
B | ILE49 |
B | GLY50 |
B | GLY52 |
B | LYS53 |
B | TYR54 |
B | SER55 |
B | VAL57 |
B | ALA70 |
B | LYS72 |
B | ILE99 |
B | GLU118 |
B | ILE120 |
B | SER179 |
B | HOH502 |
B | HOH507 |
C | GLU64 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue EDO B 405 |
Chain | Residue |
B | LEU33 |
B | TRP37 |
B | LYS83 |
B | LYS106 |
B | HOH514 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue SO4 C 401 |
Chain | Residue |
B | ARG51 |
C | ASN38 |
C | LYS39 |
C | HOH507 |
C | HOH514 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue SO4 C 402 |
Chain | Residue |
C | LYS81 |
C | ARG84 |
C | ARG159 |
C | ASN193 |
C | HOH503 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue CL C 403 |
Chain | Residue |
C | ARG199 |
C | ASN242 |
C | HOH534 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue PEG C 404 |
Chain | Residue |
A | ARG42 |
C | LYS48 |
C | ARG51 |
C | HOH505 |
site_id | AD6 |
Number of Residues | 13 |
Details | binding site for residue ATP C 405 |
Chain | Residue |
C | ILE49 |
C | GLY52 |
C | LYS53 |
C | TYR54 |
C | SER55 |
C | VAL57 |
C | ALA70 |
C | LYS72 |
C | ILE99 |
C | GLU118 |
C | ILE120 |
C | ILE178 |
C | SER179 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue EDO C 406 |
Chain | Residue |
C | GLY95 |
C | ASN97 |
C | ILE98 |
C | ARG176 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGKYSEVFnGydtecnrp..........CAIK |
Chain | Residue | Details |
A | ILE49-LYS72 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNIMI |
Chain | Residue | Details |
A | ILE156-ILE168 |