5XLS

Crystal structure of UraA in occluded conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0015205	molecular_function	nucleobase transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042906	biological_process	xanthine transport
A	0042907	molecular_function	xanthine transmembrane transporter activity
A	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue URA A 501

Chain	Residue
A	ALA31
A	TYR288
A	GLY289
A	GLU290
A	ILE345
A	HOH603
A	SER71
A	SER72
A	PHE73
A	ILE132
A	GLU241
A	HIS245
A	THR286
A	THR287

---

site_id	AC2
Number of Residues	7
Details	binding site for residue KEG A 502

Chain	Residue
A	LYS62
A	LYS109
A	GLU224
A	TRP225
A	PHE226
A	HIS264
A	ARG265

---

site_id	AC3
Number of Residues	7
Details	binding site for residue KEG A 503

Chain	Residue
A	ALA210
A	HIS211
A	HIS211
A	TRP212
A	TRP212
A	PHE213
A	PHE213

---

Functional Information from PROSITE/UniProt

site_id	PS01116
Number of Residues	21
Details	XANTH_URACIL_PERMASE Xanthine/uracil permeases family signature. IPlPVMGGvsllLYGvIgasG

Chain	Residue	Details
A	ILE329-GLY349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	82
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P0AGM7

Chain	Residue	Details
A	MET1-PRO13
A	LYS62-LYS64
A	ALA111-PRO122
A	GLY172-GLY178
A	THR249-PRO261
A	ARG299-TYR301
A	GLU355-ASN365
A	LEU402-LYS429

---

site_id	SWS_FT_FI2
Number of Residues	198
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:P0AGM7

Chain	Residue	Details
A	LEU14-VAL37
A	VAL333-ILE354
A	ASN42-CYS61
A	ALA90-LYS110
A	ALA123-ALA144
A	SER156-LEU171
A	PHE179-MET199
A	TRP225-VAL248
A	GLY262-GLY281
A	SER302-VAL319

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	TOPO_DOM: Periplasmic => ECO:0000250|UniProtKB:P0AGM7

Chain	Residue	Details
A	LEU38-ILE41
A	LEU82-VAL89
A	GLY145-ASP155
A	GLY200-GLU224
A	GLY320-PRO332

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	TRANSMEM: Discontinuously helical => ECO:0000250|UniProtKB:P0AGM7

Chain	Residue	Details
A	ILE65-LEU81
A	SER282-THR298

---

site_id	SWS_FT_FI5
Number of Residues	35
Details	INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:P0AGM7

Chain	Residue	Details
A	LEU366-GLY401

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0AGM7

Chain	Residue	Details
A	PHE73
A	GLU241
A	GLY289
A	GLU290

---