5WZ2
Crystal structure of Zika virus NS5 methyltransferase bound to SAM and RNA analogue (m7GpppA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| C | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue SAM A 601 |
| Chain | Residue |
| A | SER58 |
| A | GLU113 |
| A | VAL132 |
| A | ASP133 |
| A | VAL134 |
| A | PHE135 |
| A | ASP148 |
| A | ILE149 |
| A | HOH707 |
| A | HOH724 |
| A | GLY60 |
| A | GLY83 |
| A | CYS84 |
| A | GLY87 |
| A | GLY88 |
| A | TRP89 |
| A | LYS107 |
| A | HIS112 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue GTA A 602 |
| Chain | Residue |
| A | LYS15 |
| A | LEU18 |
| A | ASN19 |
| A | MET21 |
| A | PHE26 |
| A | SER153 |
| A | SER154 |
| A | SER217 |
| A | HOH703 |
| A | HOH709 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue SAM B 601 |
| Chain | Residue |
| B | SER58 |
| B | GLY60 |
| B | GLY83 |
| B | CYS84 |
| B | GLY88 |
| B | TRP89 |
| B | THR106 |
| B | LYS107 |
| B | HIS112 |
| B | GLU113 |
| B | VAL132 |
| B | ASP133 |
| B | VAL134 |
| B | PHE135 |
| B | ASP148 |
| B | ILE149 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GTA B 602 |
| Chain | Residue |
| B | LYS15 |
| B | LEU18 |
| B | ASN19 |
| B | MET21 |
| B | PHE26 |
| B | SER153 |
| B | SER154 |
| B | SER217 |
| B | HOH701 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue SAM C 601 |
| Chain | Residue |
| C | SER58 |
| C | GLY60 |
| C | GLY83 |
| C | CYS84 |
| C | GLY87 |
| C | GLY88 |
| C | TRP89 |
| C | LYS107 |
| C | HIS112 |
| C | GLU113 |
| C | VAL132 |
| C | ASP133 |
| C | VAL134 |
| C | PHE135 |
| C | ASP148 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GTA C 602 |
| Chain | Residue |
| C | LYS15 |
| C | LEU18 |
| C | ASN19 |
| C | MET21 |
| C | PHE26 |
| C | SER153 |
| C | SER154 |
| C | SER217 |
