5WQJ
Crystal structure of 3-Mercaptopyruvate Sulfurtransferase(3MST) in complex with compound1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001822 | biological_process | kidney development |
| A | 0001889 | biological_process | liver development |
| A | 0004792 | molecular_function | thiosulfate sulfurtransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0016784 | molecular_function | 3-mercaptopyruvate sulfurtransferase activity |
| A | 0019346 | biological_process | transsulfuration |
| A | 0021510 | biological_process | spinal cord development |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045202 | cellular_component | synapse |
| A | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| B | 0001822 | biological_process | kidney development |
| B | 0001889 | biological_process | liver development |
| B | 0004792 | molecular_function | thiosulfate sulfurtransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0016784 | molecular_function | 3-mercaptopyruvate sulfurtransferase activity |
| B | 0019346 | biological_process | transsulfuration |
| B | 0021510 | biological_process | spinal cord development |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043005 | cellular_component | neuron projection |
| B | 0045202 | cellular_component | synapse |
| B | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 7N3 A 301 |
| Chain | Residue |
| A | TRP36 |
| A | GLY249 |
| A | SER250 |
| A | VAL252 |
| A | THR253 |
| A | HOH413 |
| A | HOH420 |
| A | HOH458 |
| A | HOH528 |
| A | PRO39 |
| A | ASP73 |
| A | HIS74 |
| A | TYR108 |
| A | ARG188 |
| A | PRO196 |
| A | ARG197 |
| A | CSS248 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | ASP73 |
| A | HIS74 |
| A | MET75 |
| A | SER250 |
| A | ASP273 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 303 |
| Chain | Residue |
| A | GLU195 |
| A | ARG197 |
| A | ILE200 |
| A | HOH517 |
| A | HOH572 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 304 |
| Chain | Residue |
| A | ARG46 |
| A | SER147 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue 7N3 B 301 |
| Chain | Residue |
| B | TRP36 |
| B | PRO39 |
| B | ASP73 |
| B | HIS74 |
| B | TYR108 |
| B | ARG188 |
| B | PRO196 |
| B | ARG197 |
| B | CSS248 |
| B | GLY249 |
| B | SER250 |
| B | VAL252 |
| B | HOH435 |
| B | HOH441 |
| B | HOH467 |
| B | HOH512 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 302 |
| Chain | Residue |
| B | ASP73 |
| B | HIS74 |
| B | MET75 |
| B | SER250 |
| B | ASP273 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 303 |
| Chain | Residue |
| B | GLU195 |
| B | ARG197 |
| B | ILE200 |
| B | HOH559 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000255|PROSITE-ProRule:PRU00173, ECO:0000269|PubMed:18855522, ECO:0000269|PubMed:28079151 |
| Chain | Residue | Details |
| A | CSS248 | |
| B | CSS248 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG188 | |
| B | ARG188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P25325 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P25325 |
| Chain | Residue | Details |
| A | SER35 | |
| B | SER35 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS40 | |
| B | LYS40 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS146 | |
| A | LYS164 | |
| B | LYS146 | |
| B | LYS164 |
