5W81
Phosphorylated, ATP-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002679 | biological_process | respiratory burst involved in defense response |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005260 | molecular_function | intracellularly ATP-gated chloride channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0007507 | biological_process | heart development |
| A | 0008354 | biological_process | germ cell migration |
| A | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015701 | biological_process | bicarbonate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030217 | biological_process | T cell differentiation |
| A | 0031016 | biological_process | pancreas development |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034707 | cellular_component | chloride channel complex |
| A | 0035162 | biological_process | embryonic hemopoiesis |
| A | 0035377 | biological_process | transepithelial water transport |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0045087 | biological_process | innate immune response |
| A | 0050891 | biological_process | multicellular organismal-level water homeostasis |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060063 | biological_process | Spemann organizer formation at the embryonic shield |
| A | 0070121 | biological_process | Kupffer's vesicle development |
| A | 0090022 | biological_process | regulation of neutrophil chemotaxis |
| A | 0097535 | biological_process | lymphoid lineage cell migration into thymus |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1904322 | biological_process | cellular response to forskolin |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue ATP A 1501 |
| Chain | Residue |
| A | TRP402 |
| A | ASN1349 |
| A | MG1503 |
| A | MET459 |
| A | GLY460 |
| A | GLY462 |
| A | LYS463 |
| A | SER464 |
| A | SER465 |
| A | GLN492 |
| A | TYR1345 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue ATP A 1502 |
| Chain | Residue |
| A | LEU545 |
| A | ASN546 |
| A | SER548 |
| A | GLY550 |
| A | GLN551 |
| A | TYR1220 |
| A | THR1247 |
| A | GLY1248 |
| A | GLY1250 |
| A | LYS1251 |
| A | SER1252 |
| A | SER1253 |
| A | GLN1292 |
| A | GLN1372 |
| A | MG1504 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1503 |
| Chain | Residue |
| A | SER464 |
| A | GLN492 |
| A | ATP1501 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1504 |
| Chain | Residue |
| A | SER1252 |
| A | GLN1292 |
| A | ATP1502 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKARVALARAV |
| Chain | Residue | Details |
| A | LEU547-VAL561 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1101 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | MET1-TYR78 | |
| A | GLY150-SER195 | |
| A | GLY246-LYS299 | |
| A | ASP364-SER856 | |
| A | HIS947-PRO996 | |
| A | ARG1043-THR1103 | |
| A | ALA1160-LEU1485 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | ILE79-GLN99 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 109 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | PRO100-PHE123 | |
| A | TRP217-SER224 | |
| A | ALA321-THR340 | |
| A | GLY878-LEU924 | |
| A | ARG1020-PRO1021 | |
| A | ILE1125-GLY1138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | LEU124-LEU149 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | LEU196-ILE216 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | PHE225-MET245 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | ILE300-VAL320 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | LEU341-TYR363 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | LEU857-ALA877 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | TRANSMEM: Discontinuously helical; Name=8 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | TYR925-VAL946 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | LEU997-VAL1019 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | TYR1022-LEU1042 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | LEU1104-TRP1124 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:27912062 |
| Chain | Residue | Details |
| A | ILE1139-ILE1159 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P13569 |
| Chain | Residue | Details |
| A | GLN492 | |
| A | TYR1220 | |
| A | TRP402 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY1245 | |
| A | GLY457 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN897 | |
| A | ASN903 |
