5VZY

Crystal structure of crenezumab Fab in complex with Abeta

Replaces:  5KNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0006955	biological_process	immune response

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
A	HIS13

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
A	HIS14

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430

Chain	Residue	Details
A	LYS16

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112

Chain	Residue	Details
A	PHE19

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