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5VIM

Crystal structure of the Zika virus NS5 methyltransferase.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
A0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
A0008168molecular_functionmethyltransferase activity
A0032259biological_processmethylation
B0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
B0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
B0008168molecular_functionmethyltransferase activity
B0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue SAM A 301
ChainResidue
ASER56
AHIS110
AGLU111
AVAL130
AASP131
AVAL132
APHE133
AASP146
AHOH420
AHOH421
AHOH434
AGLY58
AGLY81
ACYS82
AGLY83
AGLY86
ATRP87
ATHR104
ALYS105

site_idAC2
Number of Residues5
Detailsbinding site for residue SO4 A 302
ChainResidue
AARG37
AARG41
ASER56
AARG57
AARG84

site_idAC3
Number of Residues20
Detailsbinding site for residue SAM B 301
ChainResidue
BSER56
BGLY58
BGLY81
BCYS82
BGLY83
BGLY86
BTRP87
BTHR104
BLYS105
BHIS110
BGLU111
BVAL130
BASP131
BVAL132
BPHE133
BASP146
BHOH419
BHOH452
BHOH474
BHOH607

site_idAC4
Number of Residues5
Detailsbinding site for residue SO4 B 302
ChainResidue
BARG37
BSER56
BARG57
BARG84
BHOH402

site_idAC5
Number of Residues8
Detailsbinding site for residue SO4 B 303
ChainResidue
BGLU149
BSER150
BSER151
BARG160
BGLY260
BSER261
BHOH401
BHOH409

site_idAC6
Number of Residues4
Detailsbinding site for residue SO4 B 304
ChainResidue
BTRP64
BARG68
BPRO210
BHOH508

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
ChainResidueDetails
ALYS61
AASP146
ALYS182
AGLU218
BLYS61
BASP146
BLYS182
BGLU218

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
ALYS13
AARG213
ASER215
ATYR220
BLYS13
BLEU16
BASN17
BMET19
BPHE24
BLYS28
BTHR104
ALEU16
BILE147
BSER150
BARG213
BSER215
BTYR220
AASN17
AMET19
APHE24
ALYS28
ATHR104
AILE147
ASER150

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345656
ChainResidueDetails
ASER56
AASP131
AVAL132
BSER56
BASP131
BVAL132

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:28291746
ChainResidueDetails
AGLY86
ATRP87
BGLY86
BTRP87

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:27386922, ECO:0000269|PubMed:27399257, ECO:0000269|PubMed:29080786
ChainResidueDetails
ALYS105
BLYS105

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:28345656
ChainResidueDetails
AHIS110
BHIS110

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:A0A024B7W1
ChainResidueDetails
AGLU111
AGLU149
BGLU111
BGLU149

site_idSWS_FT_FI8
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345656
ChainResidueDetails
AASP146
BASP146

site_idSWS_FT_FI9
Number of Residues6
DetailsSITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
ALYS61
ALYS182
AGLU218
BLYS61
BLYS182
BGLU218

site_idSWS_FT_FI10
Number of Residues2
DetailsSITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
AASP146
BASP146

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314
ChainResidueDetails
ASER56
BSER56

220113

PDB entries from 2024-05-22

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