Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 301 |
Chain | Residue |
A | HIS222 |
A | HIS226 |
A | HIS232 |
C | ASN215 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 302 |
Chain | Residue |
A | HIS172 |
A | ASP174 |
A | HIS187 |
A | HIS200 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue CA A 303 |
Chain | Residue |
A | GLY180 |
A | SER182 |
A | LEU184 |
A | ASP202 |
A | GLU205 |
A | ASP179 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue CA A 304 |
Chain | Residue |
A | ASP128 |
A | ASP203 |
A | GLU205 |
A | HOH498 |
A | HOH525 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue CA A 305 |
Chain | Residue |
A | ASP162 |
A | ASN194 |
A | GLY196 |
A | ASP198 |
A | HOH418 |
A | HOH434 |
site_id | AC6 |
Number of Residues | 19 |
Details | binding site for residue 8OA A 306 |
Chain | Residue |
A | GLY183 |
A | LEU184 |
A | LEU185 |
A | HIS222 |
A | GLU223 |
A | LEU239 |
A | PHE241 |
A | PRO242 |
A | ILE243 |
A | TYR244 |
A | THR245 |
A | THR247 |
A | PRO255 |
A | HOH474 |
B | PHE241 |
B | PRO242 |
B | ILE243 |
B | 8OA306 |
C | ASN215 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN B 301 |
Chain | Residue |
B | HIS222 |
B | HIS226 |
B | HIS232 |
D | ASN215 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN B 302 |
Chain | Residue |
B | HIS172 |
B | ASP174 |
B | HIS187 |
B | HIS200 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue CA B 303 |
Chain | Residue |
B | ASP179 |
B | GLY180 |
B | SER182 |
B | LEU184 |
B | ASP202 |
B | GLU205 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue CA B 304 |
Chain | Residue |
B | ASP128 |
B | ASP203 |
B | GLU205 |
B | HOH492 |
B | HOH496 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue CA B 305 |
Chain | Residue |
B | ASP162 |
B | ASN194 |
B | GLY196 |
B | ASP198 |
B | HOH418 |
B | HOH431 |
site_id | AD3 |
Number of Residues | 17 |
Details | binding site for residue 8OA B 306 |
Chain | Residue |
A | 8OA306 |
B | LEU184 |
B | LEU185 |
B | LEU218 |
B | HIS222 |
B | GLU223 |
B | GLY237 |
B | LEU239 |
B | PHE241 |
B | PRO242 |
B | ILE243 |
B | TYR244 |
B | THR245 |
B | HOH454 |
B | HOH465 |
C | HOH305 |
D | ASN215 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
Chain | Residue | Details |
A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
C | ASN215 | |
D | ASN215 | |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
Chain | Residue | Details |
A | SER182 | |
A | LEU184 | |
A | ASN194 | |
A | GLY196 | |
A | ASP198 | |
A | ASP202 | |
A | ASP203 | |
A | GLU205 | |
B | ASP128 | |
B | ASP162 | |
B | ASP179 | |
B | GLY180 | |
B | SER182 | |
B | LEU184 | |
B | ASN194 | |
B | GLY196 | |
B | ASP198 | |
B | ASP202 | |
B | ASP203 | |
B | GLU205 | |
A | ASP128 | |
A | ASP162 | |
A | ASP179 | |
A | GLY180 | |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
Chain | Residue | Details |
A | HIS232 | |
A | MET240 | |
B | HIS172 | |
B | ASP174 | |
B | HIS187 | |
B | HIS200 | |
B | HIS222 | |
B | HIS226 | |
B | HIS232 | |
B | MET240 | |
A | HIS222 | |
A | HIS226 | |
A | HIS172 | |
A | ASP174 | |
A | HIS187 | |
A | HIS200 | |
Chain | Residue | Details |
A | ASN117 | |
B | ASN117 | |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN152 | |
B | ASN152 | |