5UK5

Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
B	0007154	biological_process	cell communication
B	0007219	biological_process	Notch signaling pathway
B	0007275	biological_process	multicellular organism development
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCqyGwqGLyC

Chain	Residue	Details
A	CYS359-CYS370
A	CYS321-CYS332
B	CYS251-CYS262
B	CYS282-CYS293
B	CYS322-CYS333
A	CYS398-CYS409
A	CYS438-CYS449
A	CYS476-CYS487

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site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. CrCqyGWqglycdk.C

Chain	Residue	Details
A	CYS398-CYS409
A	CYS321-CYS332
B	CYS251-CYS265
B	CYS322-CYS333
A	CYS438-CYS449
A	CYS476-CYS487

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site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. ChNshggYnCvC

Chain	Residue	Details
A	CYS312-CYS323
A	CYS350-CYS361
A	CYS429-CYS440
A	CYS467-CYS478

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site_id	PS01187
Number of Residues	27
Details	EGF_CA Calcium-binding EGF-like domain signature. DvDECqlmpna........Cqnggt..ChNshggYnC

Chain	Residue	Details
A	ASP295-CYS321
A	ASN335-CYS359
A	ASP412-CYS438
A	ASP452-CYS476

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASP452
A	VAL453
A	GLU455
A	ASP469
A	GLN470
B	ASN143
B	ASN217

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with DLL4 => ECO:0000269|PubMed:25700513, ECO:0007744|PDB:4XL1

Chain	Residue	Details
A	ASP469

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: O-linked (Fuc...) threonine => ECO:0000250|UniProtKB:Q01705

Chain	Residue	Details
A	THR311
A	THR349

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000250|UniProtKB:Q01705

Chain	Residue	Details
A	SER341
A	SER378

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000269|PubMed:25700513, ECO:0007744|PDB:4XL1

Chain	Residue	Details
A	SER435

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000269|PubMed:25700513

Chain	Residue	Details
A	SER458

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: O-linked (Fuc...) threonine => ECO:0000269|PubMed:25700513, ECO:0007744|PDB:4XL1

Chain	Residue	Details
A	THR466

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