5UDL
IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0009615 | biological_process | response to virus |
A | 0019060 | biological_process | intracellular transport of viral protein in host cell |
A | 0032091 | biological_process | negative regulation of protein binding |
A | 0043657 | cellular_component | host cell |
A | 0045070 | biological_process | positive regulation of viral genome replication |
A | 0045071 | biological_process | negative regulation of viral genome replication |
A | 0045087 | biological_process | innate immune response |
A | 0051097 | biological_process | negative regulation of helicase activity |
A | 0051607 | biological_process | defense response to virus |
A | 0051707 | biological_process | response to other organism |
A | 0071357 | biological_process | cellular response to type I interferon |
A | 0071360 | biological_process | cellular response to exogenous dsRNA |
A | 0140374 | biological_process | antiviral innate immune response |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue PGE A 501 |
Chain | Residue |
A | HIS63 |
A | HOH665 |
A | HOH843 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue CA A 502 |
Chain | Residue |
A | ASP47 |
A | HOH624 |
A | HOH734 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CA A 503 |
Chain | Residue |
A | HOH887 |
A | GLU77 |
A | HOH837 |
A | HOH846 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 5 |
Details | SITE: Interaction with PPP-RNA => ECO:0000250 |
Chain | Residue | Details |
A | ASP34 | |
A | GLN42 | |
A | LYS151 | |
A | ARG187 | |
A | TYR252 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Interaction with the 5'-triphosphate group of PPP-RNA => ECO:0000250 |
Chain | Residue | Details |
A | GLN290 |