5UDK
IFIT1 monomeric mutant (L457E/L464E) with PPP-AAAA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009615 | biological_process | response to virus |
| A | 0019060 | biological_process | intracellular transport of viral protein in host cell |
| A | 0032091 | biological_process | negative regulation of protein binding |
| A | 0043657 | cellular_component | host cell |
| A | 0045070 | biological_process | positive regulation of viral genome replication |
| A | 0045071 | biological_process | negative regulation of viral genome replication |
| A | 0045087 | biological_process | innate immune response |
| A | 0051097 | biological_process | negative regulation of helicase activity |
| A | 0051607 | biological_process | defense response to virus |
| A | 0051707 | biological_process | response to other organism |
| A | 0071357 | biological_process | cellular response to type I interferon |
| A | 0071360 | biological_process | cellular response to exogenous dsRNA |
| A | 0140374 | biological_process | antiviral innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue PGE A 501 |
| Chain | Residue |
| A | GLN42 |
| A | LEU46 |
| A | THR48 |
| A | TRP147 |
| A | LYS151 |
| A | PEG502 |
| A | HOH616 |
| B | ATP1 |
| B | HOH102 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 502 |
| Chain | Residue |
| A | ALA179 |
| A | ASN216 |
| A | PGE501 |
| A | EDO503 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | ASP47 |
| A | ASP215 |
| A | ASN216 |
| A | GLY217 |
| A | TYR218 |
| A | SER248 |
| A | SER249 |
| A | PEG502 |
| A | HOH832 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PGE A 504 |
| Chain | Residue |
| A | HIS63 |
| A | HIS107 |
| A | PHE445 |
| A | HOH628 |
| A | HOH632 |
| A | HOH711 |
| A | HOH846 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 505 |
| Chain | Residue |
| A | ASP47 |
| A | HOH722 |
| A | HOH765 |
| A | HOH858 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 506 |
| Chain | Residue |
| A | GLU77 |
| A | HOH854 |
| A | HOH859 |
| A | HOH867 |
| A | HOH912 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | SITE: Interaction with PPP-RNA => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP34 | |
| A | GLN42 | |
| A | LYS151 | |
| A | ARG187 | |
| A | TYR252 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Interaction with the 5'-triphosphate group of PPP-RNA => ECO:0000250 |
| Chain | Residue | Details |
| A | GLN290 |
