5U2B
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 6WV A 601 |
| Chain | Residue |
| A | MET343 |
| A | GLU353 |
| A | LEU387 |
| A | LEU391 |
| A | ARG394 |
| A | MET421 |
| A | HIS524 |
| A | LEU525 |
| A | MET528 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 6WV B 601 |
| Chain | Residue |
| B | LEU346 |
| B | ALA350 |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | PHE404 |
| B | HIS524 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue 6WV C 601 |
| Chain | Residue |
| C | GLU353 |
| C | LEU387 |
| C | LEU391 |
| C | ARG394 |
| C | PHE404 |
| C | MET421 |
| C | HIS524 |
| C | LEU525 |
| C | MET528 |
| C | HOH759 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue 6WV D 601 |
| Chain | Residue |
| D | GLU353 |
| D | LEU387 |
| D | ARG394 |
| D | MET421 |
| D | HIS524 |
| D | HOH714 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue 6WV E 601 |
| Chain | Residue |
| E | GLU353 |
| E | LEU387 |
| E | LEU391 |
| E | ARG394 |
| E | MET421 |
| E | HIS524 |
| E | HOH722 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue 6WV F 601 |
| Chain | Residue |
| F | LEU346 |
| F | ALA350 |
| F | GLU353 |
| F | ILE424 |
| F | HIS524 |
| F | HOH702 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ILE358-GLU423 | |
| B | ILE358-GLU423 | |
| C | ILE358-GLU423 | |
| D | ILE358-GLU423 | |
| E | ILE358-GLU423 | |
| F | ILE358-GLU423 | |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| E | ARG394-VAL418 | |
| F | ILE358-LEU378 | |
| F | ARG394-VAL418 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 | |
| C | ILE358-LEU378 | |
| C | ARG394-VAL418 | |
| D | ILE358-LEU378 | |
| D | ARG394-VAL418 | |
| E | ILE358-LEU378 | |
| Chain | Residue | Details |
| A | ALA340 | |
| B | ALA340 | |
| C | ALA340 | |
| D | ALA340 | |
| E | ALA340 | |
| F | ALA340 | |
| Chain | Residue | Details |
| A | SER433 | |
| B | SER433 | |
| C | SER433 | |
| D | SER433 | |
| E | SER433 | |
| F | SER433 | |
