5SGA

Structures of product and inhibitor complexes of Streptomyces griseus protease a at 1.8 Angstroms resolution. a model for serine protease catalysis

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR CHAIN P OF TETRAPEPTIDE ACE-PRO-ALA-PRO-TYR

Chain	Residue
E	HIS57
E	SER195
E	SER214
E	GLY215
E	GLY216
E	SER217
E	GLY218
P	HOH356
P	HOH357
P	HOH387
E	VAL169
E	ASN170
E	TYR171
E	ALA192
E	GLN192
E	PRO192
E	GLY193
E	ASP194

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAGHC

Chain	Residue	Details
E	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAqpGDSGGSLF

Chain	Residue	Details
E	CYS191-PHE200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
E	HIS57
E	ASP102
E	SER195

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