5P8W
Crystal Structure of COMT in complex with [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0006584 | biological_process | catecholamine metabolic process |
A | 0008171 | molecular_function | O-methyltransferase activity |
A | 0016206 | molecular_function | catechol O-methyltransferase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0006584 | biological_process | catecholamine metabolic process |
B | 0008171 | molecular_function | O-methyltransferase activity |
B | 0016206 | molecular_function | catechol O-methyltransferase activity |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0006584 | biological_process | catecholamine metabolic process |
C | 0008171 | molecular_function | O-methyltransferase activity |
C | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue DTT A 301 |
Chain | Residue |
A | LYS5 |
A | ILE9 |
A | CYS33 |
A | TRP38 |
A | ALA39 |
A | MET40 |
A | ASN41 |
A | CYS69 |
A | HOH415 |
site_id | AC2 |
Number of Residues | 13 |
Details | binding site for residue O01 A 302 |
Chain | Residue |
A | GLY66 |
A | TYR68 |
A | MET89 |
A | GLU90 |
A | ILE91 |
A | GLY117 |
A | ALA118 |
A | SER119 |
A | GLN120 |
A | HIS142 |
A | TRP143 |
A | ARG146 |
C | HOH403 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue FMT A 303 |
Chain | Residue |
A | THR176 |
A | PRO177 |
A | ASP178 |
A | PHE179 |
A | HOH439 |
A | HOH466 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue NA A 304 |
Chain | Residue |
A | ASN41 |
A | ASP141 |
A | ASP169 |
A | ASN170 |
A | HOH472 |
A | HOH489 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue NA A 305 |
Chain | Residue |
A | VAL183 |
A | ARG184 |
A | SER186 |
A | PHE189 |
A | TYR197 |
A | HOH401 |
A | HOH531 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue DTT B 301 |
Chain | Residue |
B | ILE9 |
B | CYS33 |
B | ALA39 |
B | MET40 |
B | CYS69 |
site_id | AC7 |
Number of Residues | 14 |
Details | binding site for residue O01 B 302 |
Chain | Residue |
B | GLY66 |
B | TYR68 |
B | MET89 |
B | GLU90 |
B | ILE91 |
B | GLY117 |
B | ALA118 |
B | SER119 |
B | GLN120 |
B | HIS142 |
B | TRP143 |
B | ARG146 |
B | HOH409 |
B | HOH437 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue FMT B 303 |
Chain | Residue |
B | THR176 |
B | PRO177 |
B | ASP178 |
B | PHE179 |
B | HOH423 |
B | HOH424 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue NA B 304 |
Chain | Residue |
B | VAL183 |
B | ARG184 |
B | SER186 |
B | PHE189 |
B | HOH489 |
B | HOH496 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue NA B 305 |
Chain | Residue |
B | CYS33 |
B | LYS36 |
B | ALA39 |
B | ASN41 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue DTT C 301 |
Chain | Residue |
C | ILE9 |
C | CYS33 |
C | TYR68 |
C | CYS69 |
site_id | AD3 |
Number of Residues | 12 |
Details | binding site for residue O01 C 302 |
Chain | Residue |
A | VAL204 |
B | TYR197 |
C | GLY66 |
C | GLU90 |
C | ILE91 |
C | GLY117 |
C | ALA118 |
C | SER119 |
C | GLN120 |
C | HIS142 |
C | HOH414 |
C | HOH415 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue FMT C 303 |
Chain | Residue |
C | LYS144 |
C | ASN170 |
C | ILE172 |
C | VAL173 |
C | PRO174 |
C | GLY175 |
C | HOH436 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue NA C 304 |
Chain | Residue |
C | VAL183 |
C | ARG184 |
C | SER186 |
C | PHE189 |
C | GLU199 |
C | HOH411 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01019, ECO:0000269|PubMed:12237326 |
Chain | Residue | Details |
C | SER72 | |
C | GLU90 | |
C | ASP141 | |
A | VAL42 | |
A | SER72 | |
A | GLU90 | |
A | ASP141 | |
B | VAL42 | |
B | SER72 | |
B | GLU90 | |
B | ASP141 | |
C | VAL42 |
site_id | SWS_FT_FI2 |
Number of Residues | 9 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 |
Chain | Residue | Details |
B | GLU64 | |
B | ILE91 | |
B | SER119 | |
C | GLU64 | |
C | ILE91 | |
C | SER119 | |
A | ILE91 | |
A | SER119 | |
A | GLU64 |
site_id | SWS_FT_FI3 |
Number of Residues | 15 |
Details | BINDING: |
Chain | Residue | Details |
A | ASN170 | |
A | GLU199 | |
B | GLY117 | |
B | LYS144 | |
B | ASP169 | |
B | ASN170 | |
B | GLU199 | |
C | GLY117 | |
C | LYS144 | |
C | ASP169 | |
C | ASN170 | |
C | GLU199 | |
A | LYS144 | |
A | ASP169 | |
A | GLY117 |
site_id | SWS_FT_FI4 |
Number of Residues | 9 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | SER216 | |
A | SER217 | |
A | SER221 | |
B | SER217 | |
B | SER221 | |
C | SER216 | |
C | SER217 | |
C | SER221 | |
B | SER216 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 915 |
Chain | Residue | Details |
A | ASP141 | metal ligand |
A | LYS144 | proton shuttle (general acid/base) |
A | ASP169 | metal ligand |
A | ASN170 | metal ligand |
A | GLU199 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 915 |
Chain | Residue | Details |
B | ASP141 | metal ligand |
B | LYS144 | proton shuttle (general acid/base) |
B | ASP169 | metal ligand |
B | ASN170 | metal ligand |
B | GLU199 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 915 |
Chain | Residue | Details |
C | ASP141 | metal ligand |
C | LYS144 | proton shuttle (general acid/base) |
C | ASP169 | metal ligand |
C | ASN170 | metal ligand |
C | GLU199 | electrostatic stabiliser |