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5OYG

Structure of calcium-free mTMEM16A chloride channel at 4.06 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0005102molecular_functionsignaling receptor binding
A0005229molecular_functionintracellularly calcium-gated chloride channel activity
A0005247molecular_functionvoltage-gated chloride channel activity
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006821biological_processchloride transport
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0009897cellular_componentexternal side of plasma membrane
A0015111molecular_functioniodide transmembrane transporter activity
A0015705biological_processiodide transport
A0016324cellular_componentapical plasma membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034605biological_processcellular response to heat
A0034707cellular_componentchloride channel complex
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0046983molecular_functionprotein dimerization activity
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051649biological_processestablishment of localization in cell
A0060438biological_processtrachea development
A0070254biological_processmucus secretion
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0106091biological_processglial cell projection elongation
A1901653biological_processcellular response to peptide
A1902476biological_processchloride transmembrane transport
B0005102molecular_functionsignaling receptor binding
B0005229molecular_functionintracellularly calcium-gated chloride channel activity
B0005247molecular_functionvoltage-gated chloride channel activity
B0005254molecular_functionchloride channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006821biological_processchloride transport
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0009897cellular_componentexternal side of plasma membrane
B0015111molecular_functioniodide transmembrane transporter activity
B0015705biological_processiodide transport
B0016324cellular_componentapical plasma membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034605biological_processcellular response to heat
B0034707cellular_componentchloride channel complex
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042391biological_processregulation of membrane potential
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0046983molecular_functionprotein dimerization activity
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
B0051649biological_processestablishment of localization in cell
B0060438biological_processtrachea development
B0070254biological_processmucus secretion
B0098793cellular_componentpresynapse
B0098978cellular_componentglutamatergic synapse
B0106091biological_processglial cell projection elongation
B1901653biological_processcellular response to peptide
B1902476biological_processchloride transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1096
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29236684, ECO:0000269|PubMed:29236691
ChainResidueDetails
AMET1-ALA333
ALYS428-ASN493
ALEU564-THR581
APHE653-LEU699
APHE742-GLY758
AASP888-LEU960
BMET1-ALA333
BLYS428-ASN493
BLEU564-THR581
BPHE653-LEU699
BPHE742-GLY758
BASP888-LEU960

site_idSWS_FT_FI2
Number of Residues400
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:29236684, ECO:0000269|PubMed:29236691
ChainResidueDetails
ATRP334-LEU354
APRO407-TRP427
ALEU494-TYR514
AVAL543-TRP563
APHE582-PHE602
AMET632-LEU652
ATHR700-PHE720
APRO721-LYS741
AILE759-ILE779
APHE867-PRO887
BTRP334-LEU354
BPRO407-TRP427
BLEU494-TYR514
BVAL543-TRP563
BPHE582-PHE602
BMET632-LEU652
BTHR700-PHE720
BPRO721-LYS741
BILE759-ILE779
BPHE867-PRO887

site_idSWS_FT_FI3
Number of Residues384
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29236684, ECO:0000269|PubMed:29236691
ChainResidueDetails
ATYR355-ASN406
AARG515-ALA542
ALYS603-LEU631
ASER780-ALA866
BTYR355-ASN406
BARG515-ALA542
BLYS603-LEU631
BSER780-ALA866

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:33378669
ChainResidueDetails
AGLU425
AASP883
AASP888
BGLU425
BASP883
BASP888

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:29236691
ChainResidueDetails
BASN651
BGLU654
BGLU702
BGLU705
BGLU734
BASP738
AASN651
AGLU654
AGLU702
AGLU705
AGLU734
AASP738

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Unlikely to bind calcium but may play an important structural role => ECO:0000269|PubMed:33378669
ChainResidueDetails
ALYS428
BLYS428

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5XXA6
ChainResidueDetails
ASER196
BSER196

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN806
BASN806

219869

PDB entries from 2024-05-15

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