Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OSC

GLIC-GABAAR alpha1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 501

Chain	Residue
A	ARG76
A	ILE130
A	GLU180
E	PHE41
E	ARG104

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 502

Chain	Residue
A	PHE77
A	ARG84

site_id	AC3
Number of Residues	2
Details	binding site for residue A8W A 503

Chain	Residue
A	ARG316
A	ALA398

site_id	AC4
Number of Residues	8
Details	binding site for residue Y01 A 504

Chain	Residue
A	SER269
A	ASP286
A	ILE289
A	ALA290
A	TYR293
A	PHE297
A	ILE301
E	MET235

site_id	AC5
Number of Residues	5
Details	binding site for residue ACT B 501

Chain	Residue
A	PHE41
A	ARG104
B	ARG76
B	ILE130
B	GLU180

site_id	AC6
Number of Residues	3
Details	binding site for residue ACT B 502

Chain	Residue
B	PRO73
B	ARG84
B	TYR101

site_id	AC7
Number of Residues	2
Details	binding site for residue CL B 503

Chain	Residue
B	PHE77
B	ARG84

site_id	AC8
Number of Residues	4
Details	binding site for residue A8W B 504

Chain	Residue
B	ARG316
B	LEU394
B	ALA398
B	PHE399

site_id	AC9
Number of Residues	5
Details	binding site for residue Y01 B 505

Chain	Residue
A	MET235
B	SER269
B	ASP286
B	TYR293
B	PHE297

site_id	AD1
Number of Residues	4
Details	binding site for residue Y01 B 506

Chain	Residue
B	MET235
C	SER269
C	TYR293
C	ALA294

site_id	AD2
Number of Residues	6
Details	binding site for residue ACT C 501

Chain	Residue
B	ILE24
B	PHE41
B	ARG104
C	ARG76
C	ILE130
C	GLU180

site_id	AD3
Number of Residues	2
Details	binding site for residue CL C 502

Chain	Residue
C	PHE77
C	ARG84

site_id	AD4
Number of Residues	2
Details	binding site for residue A8W C 503

Chain	Residue
C	SER298
C	ALA398

site_id	AD5
Number of Residues	5
Details	binding site for residue ACT D 501

Chain	Residue
C	PHE41
C	ARG104
D	ARG76
D	ILE130
D	GLU180

site_id	AD6
Number of Residues	4
Details	binding site for residue ACT D 502

Chain	Residue
D	PRO73
D	ILE75
D	ARG84
D	TYR101

site_id	AD7
Number of Residues	2
Details	binding site for residue CL D 503

Chain	Residue
D	PHE77
D	ARG84

site_id	AD8
Number of Residues	6
Details	binding site for residue Y01 D 505

Chain	Residue
C	MET235
D	SER269
D	ASP286
D	ALA290
D	TYR293
D	PHE297

site_id	AD9
Number of Residues	5
Details	binding site for residue ACT E 501

Chain	Residue
D	PHE41
D	ARG104
E	ARG76
E	ILE130
E	GLU180

site_id	AE1
Number of Residues	3
Details	binding site for residue ACT E 502

Chain	Residue
E	PRO73
E	ILE75
E	ARG84

site_id	AE2
Number of Residues	2
Details	binding site for residue CL E 503

Chain	Residue
E	PHE77
E	ARG84

site_id	AE3
Number of Residues	4
Details	binding site for residue A8W E 504

Chain	Residue
E	ARG316
E	LEU394
E	ALA398
E	PHE399

site_id	AE4
Number of Residues	5
Details	binding site for residue Y01 E 505

Chain	Residue
D	LEU231
D	MET235
E	SER269
E	ALA290
E	PHE297

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	955
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN1-GLN192
B	GLN1-GLN192
C	GLN1-GLN192
D	GLN1-GLN192
E	GLN1-GLN192

site_id	SWS_FT_FI2
Number of Residues	420
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
B	LEU394-LEU415
C	LEU394-LEU415
D	LEU394-LEU415
E	LEU394-LEU415
A	TYR224-TRP245
A	VAL251-ALA272
A	MET285-VAL306
B	TYR224-TRP245
B	VAL251-ALA272
B	MET285-VAL306
C	TYR224-TRP245
C	VAL251-ALA272
C	MET285-VAL306
D	TYR224-TRP245
D	VAL251-ALA272
D	MET285-VAL306
E	TYR224-TRP245
E	VAL251-ALA272
E	MET285-VAL306
A	LEU394-LEU415

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)