5OSB
GLIC-GABAAR alpha1 chimera crystallized in complex with THDOC at pH4.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue A8Z A 501 |
| Chain | Residue |
| A | ALA304 |
| A | THR305 |
| A | TYR308 |
| A | PHE309 |
| E | GLN241 |
| E | VAL242 |
| E | PRO400 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue A8Z A 502 |
| Chain | Residue |
| A | PRO400 |
| B | ALA304 |
| B | THR305 |
| B | TYR308 |
| B | PHE309 |
| A | GLN241 |
| A | VAL242 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 503 |
| Chain | Residue |
| A | ARG76 |
| A | ILE130 |
| A | GLU180 |
| E | PHE41 |
| E | ARG104 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | PHE77 |
| A | ARG84 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue A8Z B 501 |
| Chain | Residue |
| B | GLN241 |
| B | VAL242 |
| B | TRP245 |
| B | PRO400 |
| C | ALA304 |
| C | THR305 |
| C | TYR308 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 502 |
| Chain | Residue |
| A | PHE41 |
| A | ARG104 |
| B | ARG76 |
| B | ILE130 |
| B | GLU180 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue A8Z C 501 |
| Chain | Residue |
| C | GLN241 |
| C | VAL242 |
| C | PRO400 |
| D | ALA304 |
| D | THR305 |
| D | TYR308 |
| D | PHE309 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 502 |
| Chain | Residue |
| B | PHE41 |
| B | ARG104 |
| C | ARG76 |
| C | ILE130 |
| C | LEU175 |
| C | GLU180 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 501 |
| Chain | Residue |
| C | PHE41 |
| C | ARG104 |
| D | ARG76 |
| D | ILE130 |
| D | GLU180 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 502 |
| Chain | Residue |
| D | PHE77 |
| D | ARG84 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue A8Z E 501 |
| Chain | Residue |
| D | GLN241 |
| D | VAL242 |
| E | ALA304 |
| E | THR305 |
| E | TYR308 |
| E | PHE309 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT E 502 |
| Chain | Residue |
| D | PHE41 |
| D | ARG104 |
| E | ARG76 |
| E | ILE130 |
| E | GLU180 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 955 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN1-GLN192 | |
| B | GLN1-GLN192 | |
| C | GLN1-GLN192 | |
| D | GLN1-GLN192 | |
| E | GLN1-GLN192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 405 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:P14867 |
| Chain | Residue | Details |
| E | PRO252-ARG273 | |
| E | ALA284-THR305 | |
| E | LEU394-THR413 | |
| A | VAL226-LEU246 | |
| C | PRO252-ARG273 | |
| C | ALA284-THR305 | |
| C | LEU394-THR413 | |
| D | VAL226-LEU246 | |
| D | PRO252-ARG273 | |
| D | ALA284-THR305 | |
| D | LEU394-THR413 | |
| E | VAL226-LEU246 | |
| A | PRO252-ARG273 | |
| A | ALA284-THR305 | |
| A | LEU394-THR413 | |
| B | VAL226-LEU246 | |
| B | PRO252-ARG273 | |
| B | ALA284-THR305 | |
| B | LEU394-THR413 | |
| C | VAL226-LEU246 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | ASN247-VAL251 | |
| B | ASN247-VAL251 | |
| C | ASN247-VAL251 | |
| D | ASN247-VAL251 | |
| E | ASN247-VAL251 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 115 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ASN274-THR283 | |
| E | TYR414-GLN428 | |
| A | TYR414-GLN428 | |
| B | ASN274-THR283 | |
| B | TYR414-GLN428 | |
| C | ASN274-THR283 | |
| C | TYR414-GLN428 | |
| D | ASN274-THR283 | |
| D | TYR414-GLN428 | |
| E | ASN274-THR283 |
