5ON1
Crystal structure of NikA in complex with hydroxylated Fe-L1 (N-(2-hydroxybenzyl)-N'-(2-thiomethylbenzyl)-N,N'-ethylenediamine diacetic acid)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue FE A 601 |
| Chain | Residue |
| A | 9YK602 |
| A | HOH1068 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 9YK A 602 |
| Chain | Residue |
| A | FE601 |
| A | HOH797 |
| A | HOH927 |
| A | HOH939 |
| A | TYR22 |
| A | MET27 |
| A | ARG97 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | THR490 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 603 |
| Chain | Residue |
| A | ARG68 |
| A | ASP69 |
| A | ASP70 |
| A | HOH719 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 604 |
| Chain | Residue |
| A | ASN261 |
| A | LEU263 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 605 |
| Chain | Residue |
| A | ASN235 |
| A | ALA237 |
| A | GLN423 |
| A | HOH759 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | GLU343 |
| A | ARG384 |
| A | ARG389 |
| B | LEU430 |
| B | ARG457 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | ILE246 |
| A | TYR485 |
| A | ALA486 |
| A | HOH836 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 608 |
| Chain | Residue |
| A | ASN220 |
| A | GLU247 |
| A | ARG396 |
| A | ALA489 |
| A | THR490 |
| A | DTD612 |
| A | HOH725 |
| A | HOH756 |
| A | HOH1049 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 609 |
| Chain | Residue |
| A | GLU102 |
| A | ASN105 |
| A | LYS123 |
| A | ASP227 |
| A | THR228 |
| A | ARG231 |
| A | HOH708 |
| A | HOH712 |
| A | HOH869 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 610 |
| Chain | Residue |
| A | THR23 |
| A | GLN26 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 611 |
| Chain | Residue |
| A | PHE209 |
| A | GLU210 |
| A | GLY212 |
| A | TYR238 |
| A | LYS477 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue DTD A 612 |
| Chain | Residue |
| A | TRP10 |
| A | PRO11 |
| A | ARG205 |
| A | GLY219 |
| A | ASN220 |
| A | GLY222 |
| A | LEU223 |
| A | GOL608 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 613 |
| Chain | Residue |
| A | PHE229 |
| A | SER233 |
| A | THR286 |
| B | ASN302 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 614 |
| Chain | Residue |
| A | TYR22 |
| A | ARG97 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 615 |
| Chain | Residue |
| A | LYS330 |
| A | ASP331 |
| A | ILE332 |
| A | ARG365 |
| B | LYS148 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 616 |
| Chain | Residue |
| A | SER53 |
| A | TRP54 |
| A | HOH805 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 617 |
| Chain | Residue |
| A | ASN149 |
| A | LYS157 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 618 |
| Chain | Residue |
| A | HIS442 |
| A | ASP443 |
| A | HOH1039 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 619 |
| Chain | Residue |
| A | SER45 |
| A | VAL46 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 620 |
| Chain | Residue |
| A | GLN361 |
| A | SER372 |
| A | LEU373 |
| A | HOH711 |
| A | HOH760 |
| B | LYS157 |
| B | HOH746 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 621 |
| Chain | Residue |
| A | LYS335 |
| A | HOH1023 |
| B | ARG341 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 622 |
| Chain | Residue |
| A | LYS115 |
| A | HOH1114 |
| site_id | AE5 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 623 |
| Chain | Residue |
| A | TYR271 |
| A | ALA272 |
| A | VAL273 |
| A | LYS275 |
| A | SER308 |
| A | GLN309 |
| A | TYR310 |
| A | HOH704 |
| A | HOH705 |
| A | HOH1031 |
| A | ASN270 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 624 |
| Chain | Residue |
| A | ASN302 |
| A | GLY304 |
| A | HOH902 |
| B | ALA230 |
| B | SER233 |
| B | LEU242 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 625 |
| Chain | Residue |
| A | ARG89 |
| A | LEU92 |
| A | ARG95 |
| A | VAL108 |
| A | ASP109 |
| A | VAL110 |
| A | ASN281 |
| A | HOH790 |
| A | HOH1005 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue FE B 601 |
| Chain | Residue |
| B | 9YK602 |
| B | HOH994 |
| site_id | AE9 |
| Number of Residues | 11 |
| Details | binding site for residue 9YK B 602 |
| Chain | Residue |
| B | TYR22 |
| B | MET27 |
| B | ARG97 |
| B | ARG137 |
| B | TRP398 |
| B | THR490 |
| B | FE601 |
| B | HOH754 |
| B | HOH788 |
| B | HOH863 |
| B | HOH916 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 603 |
| Chain | Residue |
| A | ASN75 |
| B | PRO225 |
| B | ASP227 |
| B | HOH704 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| A | HOH980 |
| B | MET472 |
| B | ALA486 |
| B | HOH964 |
| site_id | AF3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | ASN220 |
| B | GLU247 |
| B | ALA489 |
| B | THR490 |
| B | DTD606 |
| B | HOH742 |
| B | HOH831 |
| B | HOH975 |
| site_id | AF4 |
| Number of Residues | 9 |
| Details | binding site for residue DTD B 606 |
| Chain | Residue |
| B | TRP10 |
| B | PRO11 |
| B | ARG205 |
| B | GLY219 |
| B | ASN220 |
| B | GLY222 |
| B | LEU223 |
| B | GOL605 |
| B | HOH779 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 607 |
| Chain | Residue |
| B | TYR22 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 608 |
| Chain | Residue |
| B | ARG384 |
| B | ARG389 |
| B | HOH735 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 609 |
| Chain | Residue |
| B | GLU221 |
| B | VAL249 |
| B | SER353 |
| B | MET356 |
| B | PHE394 |
| B | ARG396 |
| B | HOH718 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 610 |
| Chain | Residue |
| B | ARG180 |
| B | GLU182 |
| B | HOH1060 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
