5OIV
Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) D43A variant in complex with serine and glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004573 | molecular_function | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0008152 | biological_process | metabolic process |
| A | 0009311 | biological_process | oligosaccharide metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0102547 | molecular_function | glucosylglycerate hydrolase activity |
| B | 0004573 | molecular_function | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006487 | biological_process | protein N-linked glycosylation |
| B | 0008152 | biological_process | metabolic process |
| B | 0009311 | biological_process | oligosaccharide metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0102547 | molecular_function | glucosylglycerate hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | GLN11 |
| A | ARG125 |
| A | HIS129 |
| A | GLY446 |
| A | HOH654 |
| A | HOH664 |
| A | HOH754 |
| B | GLU399 |
| B | ARG402 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | GLU399 |
| A | ARG402 |
| A | HOH626 |
| A | HOH638 |
| A | HOH872 |
| B | GLN11 |
| B | ARG125 |
| B | HIS129 |
| B | GLY446 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | MET153 |
| A | ARG154 |
| A | ARG157 |
| A | ASP279 |
| A | HOH738 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | TYR36 |
| A | TRP40 |
| A | TRP42 |
| A | GLN115 |
| A | GLN434 |
| A | SER510 |
| A | HOH639 |
| A | HOH671 |
| A | HOH690 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | HIS334 |
| A | HOH835 |
| B | GLN264 |
| B | TYR284 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | GLN264 |
| A | TYR284 |
| B | HIS334 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | ILE210 |
| A | GLY430 |
| A | MET432 |
| A | HOH710 |
| A | HOH825 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | TYR202 |
| A | GLN203 |
| A | ARG204 |
| A | ASP223 |
| A | HOH687 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | GLU296 |
| A | THR297 |
| A | THR298 |
| A | TRP315 |
| A | HOH614 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue SER A 510 |
| Chain | Residue |
| A | TRP40 |
| A | HIS78 |
| A | TYR88 |
| A | ASP182 |
| A | ARG216 |
| A | TYR222 |
| A | TYR375 |
| A | GOL504 |
| A | HOH630 |
| A | HOH667 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GLY A 511 |
| Chain | Residue |
| A | GLU345 |
| A | ARG400 |
| A | LEU403 |
| A | HOH635 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue GLY A 512 |
| Chain | Residue |
| A | ARG338 |
| A | GLU345 |
| A | ARG400 |
| B | ASP272 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue GLY A 513 |
| Chain | Residue |
| A | ARG168 |
| A | PHE308 |
| A | TRP315 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | ARG154 |
| B | ARG157 |
| B | ASP279 |
| B | HOH833 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | TYR36 |
| B | TRP40 |
| B | TRP42 |
| B | GLN115 |
| B | GLN434 |
| B | SER504 |
| B | HOH616 |
| B | HOH694 |
| B | HOH727 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | GLU296 |
| B | THR297 |
| B | THR298 |
| B | GLN300 |
| B | ARG306 |
| B | TRP315 |
| B | HOH728 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue SER B 504 |
| Chain | Residue |
| B | ARG216 |
| B | TYR375 |
| B | GOL502 |
| B | HOH617 |
| B | HOH708 |
| B | TRP40 |
| B | HIS78 |
| B | TYR88 |
| B | ASP182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:31316802 |
| Chain | Residue | Details |
| A | ASP182 | |
| B | ASP182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:31316802 |
| Chain | Residue | Details |
| A | GLU419 | |
| B | GLU419 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31316802 |
| Chain | Residue | Details |
| A | TYR36 | |
| B | TRP40 | |
| B | TYR88 | |
| B | GLN115 | |
| B | GLY180 | |
| B | ARG216 | |
| B | TYR375 | |
| B | GLN434 | |
| A | TRP40 | |
| A | TYR88 | |
| A | GLN115 | |
| A | GLY180 | |
| A | ARG216 | |
| A | TYR375 | |
| A | GLN434 | |
| B | TYR36 |
