5NZZ

Crystal structure of phosphorylated p38aMAPK in complex with TAB1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001701	biological_process	in utero embryonic development
A	0003007	biological_process	heart morphogenesis
A	0003279	biological_process	cardiac septum development
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0007179	biological_process	transforming growth factor beta receptor signaling pathway
A	0010008	cellular_component	endosome membrane
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0019209	molecular_function	kinase activator activity
A	0030324	biological_process	lung development
A	0032991	cellular_component	protein-containing complex
A	0035904	biological_process	aorta development
A	0038061	biological_process	non-canonical NF-kappaB signal transduction
A	0043410	biological_process	positive regulation of MAPK cascade
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0044877	molecular_function	protein-containing complex binding
A	0048273	molecular_function	mitogen-activated protein kinase p38 binding
A	0060090	molecular_function	molecular adaptor activity
A	0060976	biological_process	coronary vasculature development
A	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
A	0141111	biological_process	positive regulation of cGAS/STING signaling pathway
B	0001701	biological_process	in utero embryonic development
B	0003007	biological_process	heart morphogenesis
B	0003279	biological_process	cardiac septum development
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006470	biological_process	protein dephosphorylation
B	0007179	biological_process	transforming growth factor beta receptor signaling pathway
B	0010008	cellular_component	endosome membrane
B	0016020	cellular_component	membrane
B	0016607	cellular_component	nuclear speck
B	0019209	molecular_function	kinase activator activity
B	0030324	biological_process	lung development
B	0032991	cellular_component	protein-containing complex
B	0035904	biological_process	aorta development
B	0038061	biological_process	non-canonical NF-kappaB signal transduction
B	0043410	biological_process	positive regulation of MAPK cascade
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0044877	molecular_function	protein-containing complex binding
B	0048273	molecular_function	mitogen-activated protein kinase p38 binding
B	0060090	molecular_function	molecular adaptor activity
B	0060976	biological_process	coronary vasculature development
B	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
B	0141111	biological_process	positive regulation of cGAS/STING signaling pathway
C	0001701	biological_process	in utero embryonic development
C	0003007	biological_process	heart morphogenesis
C	0003279	biological_process	cardiac septum development
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006470	biological_process	protein dephosphorylation
C	0007179	biological_process	transforming growth factor beta receptor signaling pathway
C	0010008	cellular_component	endosome membrane
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0019209	molecular_function	kinase activator activity
C	0030324	biological_process	lung development
C	0032991	cellular_component	protein-containing complex
C	0035904	biological_process	aorta development
C	0038061	biological_process	non-canonical NF-kappaB signal transduction
C	0043410	biological_process	positive regulation of MAPK cascade
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0044877	molecular_function	protein-containing complex binding
C	0048273	molecular_function	mitogen-activated protein kinase p38 binding
C	0060090	molecular_function	molecular adaptor activity
C	0060976	biological_process	coronary vasculature development
C	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
C	0141111	biological_process	positive regulation of cGAS/STING signaling pathway
D	0001701	biological_process	in utero embryonic development
D	0003007	biological_process	heart morphogenesis
D	0003279	biological_process	cardiac septum development
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0006470	biological_process	protein dephosphorylation
D	0007179	biological_process	transforming growth factor beta receptor signaling pathway
D	0010008	cellular_component	endosome membrane
D	0016020	cellular_component	membrane
D	0016607	cellular_component	nuclear speck
D	0019209	molecular_function	kinase activator activity
D	0030324	biological_process	lung development
D	0032991	cellular_component	protein-containing complex
D	0035904	biological_process	aorta development
D	0038061	biological_process	non-canonical NF-kappaB signal transduction
D	0043410	biological_process	positive regulation of MAPK cascade
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0044877	molecular_function	protein-containing complex binding
D	0048273	molecular_function	mitogen-activated protein kinase p38 binding
D	0060090	molecular_function	molecular adaptor activity
D	0060976	biological_process	coronary vasculature development
D	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
D	0141111	biological_process	positive regulation of cGAS/STING signaling pathway
E	0000077	biological_process	DNA damage checkpoint signaling
E	0000165	biological_process	MAPK cascade
E	0000902	biological_process	cell morphogenesis
E	0000922	cellular_component	spindle pole
E	0001502	biological_process	cartilage condensation
E	0001525	biological_process	angiogenesis
E	0001649	biological_process	osteoblast differentiation
E	0001890	biological_process	placenta development
E	0002021	biological_process	response to dietary excess
E	0002062	biological_process	chondrocyte differentiation
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004707	molecular_function	MAP kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006006	biological_process	glucose metabolic process
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006366	biological_process	transcription by RNA polymerase II
E	0006468	biological_process	protein phosphorylation
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
E	0007519	biological_process	skeletal muscle tissue development
E	0010628	biological_process	positive regulation of gene expression
E	0010831	biological_process	positive regulation of myotube differentiation
E	0016301	molecular_function	kinase activity
E	0016607	cellular_component	nuclear speck
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0019395	biological_process	fatty acid oxidation
E	0019899	molecular_function	enzyme binding
E	0019903	molecular_function	protein phosphatase binding
E	0030278	biological_process	regulation of ossification
E	0030316	biological_process	osteoclast differentiation
E	0031098	biological_process	stress-activated protein kinase signaling cascade
E	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
E	0032495	biological_process	response to muramyl dipeptide
E	0032496	biological_process	response to lipopolysaccharide
E	0032735	biological_process	positive regulation of interleukin-12 production
E	0032868	biological_process	response to insulin
E	0035331	biological_process	negative regulation of hippo signaling
E	0035556	biological_process	intracellular signal transduction
E	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
E	0035994	biological_process	response to muscle stretch
E	0038066	biological_process	p38MAPK cascade
E	0042307	biological_process	positive regulation of protein import into nucleus
E	0042770	biological_process	signal transduction in response to DNA damage
E	0043229	cellular_component	intracellular organelle
E	0045648	biological_process	positive regulation of erythrocyte differentiation
E	0045663	biological_process	positive regulation of myoblast differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046323	biological_process	glucose import
E	0046326	biological_process	positive regulation of glucose import
E	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
E	0048273	molecular_function	mitogen-activated protein kinase p38 binding
E	0048863	biological_process	stem cell differentiation
E	0051146	biological_process	striated muscle cell differentiation
E	0051403	biological_process	stress-activated MAPK cascade
E	0051525	molecular_function	NFAT protein binding
E	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
E	0060348	biological_process	bone development
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0071223	biological_process	cellular response to lipoteichoic acid
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0071479	biological_process	cellular response to ionizing radiation
E	0071493	biological_process	cellular response to UV-B
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090336	biological_process	positive regulation of brown fat cell differentiation
E	0090400	biological_process	stress-induced premature senescence
E	0098586	biological_process	cellular response to virus
E	0098978	cellular_component	glutamatergic synapse
E	0099179	biological_process	regulation of synaptic membrane adhesion
E	0106310	molecular_function	protein serine kinase activity
E	1900015	biological_process	regulation of cytokine production involved in inflammatory response
E	1901741	biological_process	positive regulation of myoblast fusion
E	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
F	0000077	biological_process	DNA damage checkpoint signaling
F	0000165	biological_process	MAPK cascade
F	0000902	biological_process	cell morphogenesis
F	0000922	cellular_component	spindle pole
F	0001502	biological_process	cartilage condensation
F	0001525	biological_process	angiogenesis
F	0001649	biological_process	osteoblast differentiation
F	0001890	biological_process	placenta development
F	0002021	biological_process	response to dietary excess
F	0002062	biological_process	chondrocyte differentiation
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004707	molecular_function	MAP kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006468	biological_process	protein phosphorylation
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
F	0007519	biological_process	skeletal muscle tissue development
F	0010628	biological_process	positive regulation of gene expression
F	0010831	biological_process	positive regulation of myotube differentiation
F	0016301	molecular_function	kinase activity
F	0016607	cellular_component	nuclear speck
F	0018105	biological_process	peptidyl-serine phosphorylation
F	0019395	biological_process	fatty acid oxidation
F	0019899	molecular_function	enzyme binding
F	0019903	molecular_function	protein phosphatase binding
F	0030278	biological_process	regulation of ossification
F	0030316	biological_process	osteoclast differentiation
F	0031098	biological_process	stress-activated protein kinase signaling cascade
F	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
F	0032495	biological_process	response to muramyl dipeptide
F	0032496	biological_process	response to lipopolysaccharide
F	0032735	biological_process	positive regulation of interleukin-12 production
F	0032868	biological_process	response to insulin
F	0035331	biological_process	negative regulation of hippo signaling
F	0035556	biological_process	intracellular signal transduction
F	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
F	0035994	biological_process	response to muscle stretch
F	0038066	biological_process	p38MAPK cascade
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0042770	biological_process	signal transduction in response to DNA damage
F	0043229	cellular_component	intracellular organelle
F	0045648	biological_process	positive regulation of erythrocyte differentiation
F	0045663	biological_process	positive regulation of myoblast differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046323	biological_process	glucose import
F	0046326	biological_process	positive regulation of glucose import
F	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
F	0048273	molecular_function	mitogen-activated protein kinase p38 binding
F	0048863	biological_process	stem cell differentiation
F	0051146	biological_process	striated muscle cell differentiation
F	0051403	biological_process	stress-activated MAPK cascade
F	0051525	molecular_function	NFAT protein binding
F	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
F	0060348	biological_process	bone development
F	0071222	biological_process	cellular response to lipopolysaccharide
F	0071223	biological_process	cellular response to lipoteichoic acid
F	0071356	biological_process	cellular response to tumor necrosis factor
F	0071479	biological_process	cellular response to ionizing radiation
F	0071493	biological_process	cellular response to UV-B
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0090336	biological_process	positive regulation of brown fat cell differentiation
F	0090400	biological_process	stress-induced premature senescence
F	0098586	biological_process	cellular response to virus
F	0098978	cellular_component	glutamatergic synapse
F	0099179	biological_process	regulation of synaptic membrane adhesion
F	0106310	molecular_function	protein serine kinase activity
F	1900015	biological_process	regulation of cytokine production involved in inflammatory response
F	1901741	biological_process	positive regulation of myoblast fusion
F	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
G	0000077	biological_process	DNA damage checkpoint signaling
G	0000165	biological_process	MAPK cascade
G	0000902	biological_process	cell morphogenesis
G	0000922	cellular_component	spindle pole
G	0001502	biological_process	cartilage condensation
G	0001525	biological_process	angiogenesis
G	0001649	biological_process	osteoblast differentiation
G	0001890	biological_process	placenta development
G	0002021	biological_process	response to dietary excess
G	0002062	biological_process	chondrocyte differentiation
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004707	molecular_function	MAP kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006366	biological_process	transcription by RNA polymerase II
G	0006468	biological_process	protein phosphorylation
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
G	0007519	biological_process	skeletal muscle tissue development
G	0010628	biological_process	positive regulation of gene expression
G	0010831	biological_process	positive regulation of myotube differentiation
G	0016301	molecular_function	kinase activity
G	0016607	cellular_component	nuclear speck
G	0018105	biological_process	peptidyl-serine phosphorylation
G	0019395	biological_process	fatty acid oxidation
G	0019899	molecular_function	enzyme binding
G	0019903	molecular_function	protein phosphatase binding
G	0030278	biological_process	regulation of ossification
G	0030316	biological_process	osteoclast differentiation
G	0031098	biological_process	stress-activated protein kinase signaling cascade
G	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
G	0032495	biological_process	response to muramyl dipeptide
G	0032496	biological_process	response to lipopolysaccharide
G	0032735	biological_process	positive regulation of interleukin-12 production
G	0032868	biological_process	response to insulin
G	0035331	biological_process	negative regulation of hippo signaling
G	0035556	biological_process	intracellular signal transduction
G	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
G	0035994	biological_process	response to muscle stretch
G	0038066	biological_process	p38MAPK cascade
G	0042307	biological_process	positive regulation of protein import into nucleus
G	0042770	biological_process	signal transduction in response to DNA damage
G	0043229	cellular_component	intracellular organelle
G	0045648	biological_process	positive regulation of erythrocyte differentiation
G	0045663	biological_process	positive regulation of myoblast differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046323	biological_process	glucose import
G	0046326	biological_process	positive regulation of glucose import
G	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
G	0048273	molecular_function	mitogen-activated protein kinase p38 binding
G	0048863	biological_process	stem cell differentiation
G	0051146	biological_process	striated muscle cell differentiation
G	0051403	biological_process	stress-activated MAPK cascade
G	0051525	molecular_function	NFAT protein binding
G	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
G	0060348	biological_process	bone development
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0071223	biological_process	cellular response to lipoteichoic acid
G	0071356	biological_process	cellular response to tumor necrosis factor
G	0071479	biological_process	cellular response to ionizing radiation
G	0071493	biological_process	cellular response to UV-B
G	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
G	0090336	biological_process	positive regulation of brown fat cell differentiation
G	0090400	biological_process	stress-induced premature senescence
G	0098586	biological_process	cellular response to virus
G	0098978	cellular_component	glutamatergic synapse
G	0099179	biological_process	regulation of synaptic membrane adhesion
G	0106310	molecular_function	protein serine kinase activity
G	1900015	biological_process	regulation of cytokine production involved in inflammatory response
G	1901741	biological_process	positive regulation of myoblast fusion
G	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
H	0000077	biological_process	DNA damage checkpoint signaling
H	0000165	biological_process	MAPK cascade
H	0000902	biological_process	cell morphogenesis
H	0000922	cellular_component	spindle pole
H	0001502	biological_process	cartilage condensation
H	0001525	biological_process	angiogenesis
H	0001649	biological_process	osteoblast differentiation
H	0001890	biological_process	placenta development
H	0002021	biological_process	response to dietary excess
H	0002062	biological_process	chondrocyte differentiation
H	0004672	molecular_function	protein kinase activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004707	molecular_function	MAP kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006468	biological_process	protein phosphorylation
H	0006915	biological_process	apoptotic process
H	0006974	biological_process	DNA damage response
H	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
H	0007519	biological_process	skeletal muscle tissue development
H	0010628	biological_process	positive regulation of gene expression
H	0010831	biological_process	positive regulation of myotube differentiation
H	0016301	molecular_function	kinase activity
H	0016607	cellular_component	nuclear speck
H	0018105	biological_process	peptidyl-serine phosphorylation
H	0019395	biological_process	fatty acid oxidation
H	0019899	molecular_function	enzyme binding
H	0019903	molecular_function	protein phosphatase binding
H	0030278	biological_process	regulation of ossification
H	0030316	biological_process	osteoclast differentiation
H	0031098	biological_process	stress-activated protein kinase signaling cascade
H	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
H	0032495	biological_process	response to muramyl dipeptide
H	0032496	biological_process	response to lipopolysaccharide
H	0032735	biological_process	positive regulation of interleukin-12 production
H	0032868	biological_process	response to insulin
H	0035331	biological_process	negative regulation of hippo signaling
H	0035556	biological_process	intracellular signal transduction
H	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
H	0035994	biological_process	response to muscle stretch
H	0038066	biological_process	p38MAPK cascade
H	0042307	biological_process	positive regulation of protein import into nucleus
H	0042770	biological_process	signal transduction in response to DNA damage
H	0043229	cellular_component	intracellular organelle
H	0045648	biological_process	positive regulation of erythrocyte differentiation
H	0045663	biological_process	positive regulation of myoblast differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046323	biological_process	glucose import
H	0046326	biological_process	positive regulation of glucose import
H	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
H	0048273	molecular_function	mitogen-activated protein kinase p38 binding
H	0048863	biological_process	stem cell differentiation
H	0051146	biological_process	striated muscle cell differentiation
H	0051403	biological_process	stress-activated MAPK cascade
H	0051525	molecular_function	NFAT protein binding
H	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
H	0060348	biological_process	bone development
H	0071222	biological_process	cellular response to lipopolysaccharide
H	0071223	biological_process	cellular response to lipoteichoic acid
H	0071356	biological_process	cellular response to tumor necrosis factor
H	0071479	biological_process	cellular response to ionizing radiation
H	0071493	biological_process	cellular response to UV-B
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090336	biological_process	positive regulation of brown fat cell differentiation
H	0090400	biological_process	stress-induced premature senescence
H	0098586	biological_process	cellular response to virus
H	0098978	cellular_component	glutamatergic synapse
H	0099179	biological_process	regulation of synaptic membrane adhesion
H	0106310	molecular_function	protein serine kinase activity
H	1900015	biological_process	regulation of cytokine production involved in inflammatory response
H	1901741	biological_process	positive regulation of myoblast fusion
H	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue NI A 601

Chain	Residue
A	ASN69
A	GLY70

---

site_id	AC2
Number of Residues	2
Details	binding site for residue NI B 601

Chain	Residue
B	ASN69
B	GLY70

---

site_id	AC3
Number of Residues	2
Details	binding site for residue NI C 601

Chain	Residue
C	ASN69
C	GLY70

---

site_id	AC4
Number of Residues	2
Details	binding site for residue NI D 601

Chain	Residue
D	ASN69
D	GLY70

---

site_id	AC5
Number of Residues	15
Details	binding site for residue AGS E 401

Chain	Residue
E	VAL38
E	ALA51
E	LYS53
E	GLU71
E	THR106
E	HIS107
E	MET109
E	ASP112
E	SER154
E	ASN155
E	ASP168
E	GLY170
E	MG402
E	HOH509
E	SER37

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG E 402

Chain	Residue
E	ASN155
E	ASP168
E	AGS401

---

site_id	AC7
Number of Residues	2
Details	binding site for residue NI E 403

Chain	Residue
E	ASP145
E	HIS174

---

site_id	AC8
Number of Residues	16
Details	binding site for residue AGS F 401

Chain	Residue
F	SER37
F	VAL38
F	ALA51
F	LYS53
F	GLU71
F	ILE84
F	THR106
F	HIS107
F	LEU108
F	MET109
F	ASP112
F	SER154
F	ASN155
F	LEU167
F	ASP168
F	MG402

---

site_id	AC9
Number of Residues	3
Details	binding site for residue MG F 402

Chain	Residue
F	ASN155
F	ASP168
F	AGS401

---

site_id	AD1
Number of Residues	2
Details	binding site for residue NI F 403

Chain	Residue
F	ASP145
F	HIS174

---

site_id	AD2
Number of Residues	14
Details	binding site for residue AGS G 500

Chain	Residue
G	SER37
G	VAL38
G	ALA51
G	LYS53
G	GLU71
G	THR106
G	HIS107
G	MET109
G	ASP112
G	SER154
G	ASN155
G	LEU167
G	ASP168
G	MG501

---

site_id	AD3
Number of Residues	3
Details	binding site for residue MG G 501

Chain	Residue
G	ASN155
G	ASP168
G	AGS500

---

site_id	AD4
Number of Residues	2
Details	binding site for residue MG G 502

Chain	Residue
G	HIS174
G	TYR323

---

site_id	AD5
Number of Residues	13
Details	binding site for residue AGS H 500

Chain	Residue
H	SER37
H	VAL38
H	SER56
H	GLU71
H	HIS107
H	MET109
H	ASP112
H	SER154
H	ASN155
H	LEU167
H	ASP168
H	GLY170
H	MG501

---

site_id	AD6
Number of Residues	4
Details	binding site for residue MG H 501

Chain	Residue
H	SER154
H	ASN155
H	ASP168
H	AGS500

---

site_id	AD7
Number of Residues	2
Details	binding site for residue MG H 502

Chain	Residue
H	ASP145
H	HIS174

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK

Chain	Residue	Details
E	VAL30-LYS54

---

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC

Chain	Residue	Details
E	PHE59-CYS162

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
E	ASP168
F	ASP168
G	ASP168
H	ASP168

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
E	VAL30
E	LYS53
F	VAL30
F	LYS53
G	VAL30
G	LYS53
H	VAL30
H	LYS53

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16539

Chain	Residue	Details
E	SER2
F	SER2
G	SER2
H	SER2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q16539

Chain	Residue	Details
E	THR16
F	THR16
G	THR16
H	THR16

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q16539

Chain	Residue	Details
E	LYS53
E	LYS152
F	LYS53
F	LYS152
G	LYS53
G	LYS152
H	LYS53
H	LYS152

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000250

Chain	Residue	Details
E	TPO180
F	TPO180
G	TPO180
H	TPO180

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000250

Chain	Residue	Details
E	PTR182
F	PTR182
G	PTR182
H	PTR182

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000250|UniProtKB:Q16539

Chain	Residue	Details
E	TYR323
F	TYR323
G	TYR323
H	TYR323

---