Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NZ1

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with sutezolid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046677	biological_process	response to antibiotic
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046677	biological_process	response to antibiotic
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046677	biological_process	response to antibiotic
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006355	biological_process	regulation of DNA-templated transcription
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046677	biological_process	response to antibiotic
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006355	biological_process	regulation of DNA-templated transcription
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046677	biological_process	response to antibiotic
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006355	biological_process	regulation of DNA-templated transcription
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0046677	biological_process	response to antibiotic
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0006355	biological_process	regulation of DNA-templated transcription
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 9EN A 301

Chain	Residue
A	LEU87
A	THR149
A	ASN176
A	ASN179
A	GLU180
A	LEU183
A	TRP207
A	TRP103
A	GLY106
A	ILE107
A	PHE110
A	TRP138
A	MET142
A	TRP145
A	TYR148

site_id	AC2
Number of Residues	14
Details	binding site for residue 9EN C 301

Chain	Residue
C	MET102
C	TRP103
C	GLY106
C	ILE107
C	PHE110
C	PHE114
C	MET142
C	TYR148
C	THR149
C	VAL152
C	ASN176
C	ASN179
C	GLU180
C	TRP207

site_id	AC3
Number of Residues	13
Details	binding site for residue 9EN D 301

Chain	Residue
D	LEU87
D	MET102
D	TRP103
D	GLY106
D	ILE107
D	PHE110
D	PHE114
D	TRP138
D	TRP145
D	THR149
D	ASN176
D	ASN179
D	GLU180

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	DNA_BIND: H-T-H motif => ECO:0000255\|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	SER46-PHE65
B	SER46-PHE65
C	SER46-PHE65
D	SER46-PHE65
E	SER46-PHE65
F	SER46-PHE65
G	SER46-PHE65
H	SER46-PHE65

site_id	SWS_FT_FI2
Number of Residues	16
Details	SITE: Inhibitor-binding

Chain	Residue	Details
A	ASN176
E	ASN179
F	ASN176
F	ASN179
G	ASN176
G	ASN179
H	ASN176
H	ASN179
A	ASN179
B	ASN176
B	ASN179
C	ASN176
C	ASN179
D	ASN176
D	ASN179
E	ASN176

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)