5NSD
Co-crystal structure of NAMPT dimer with KPT-9274
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005125 | molecular_function | cytokine activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0007165 | biological_process | signal transduction |
A | 0007267 | biological_process | cell-cell signaling |
A | 0007623 | biological_process | circadian rhythm |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0008286 | biological_process | insulin receptor signaling pathway |
A | 0009435 | biological_process | NAD biosynthetic process |
A | 0016607 | cellular_component | nuclear speck |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
A | 0030054 | cellular_component | cell junction |
A | 0032922 | biological_process | circadian regulation of gene expression |
A | 0034356 | biological_process | NAD biosynthesis via nicotinamide riboside salvage pathway |
A | 0042802 | molecular_function | identical protein binding |
A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
A | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
A | 0048511 | biological_process | rhythmic process |
A | 0051770 | biological_process | positive regulation of nitric-oxide synthase biosynthetic process |
A | 0060612 | biological_process | adipose tissue development |
A | 0070062 | cellular_component | extracellular exosome |
B | 0005125 | molecular_function | cytokine activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0007165 | biological_process | signal transduction |
B | 0007267 | biological_process | cell-cell signaling |
B | 0007623 | biological_process | circadian rhythm |
B | 0008284 | biological_process | positive regulation of cell population proliferation |
B | 0008286 | biological_process | insulin receptor signaling pathway |
B | 0009435 | biological_process | NAD biosynthetic process |
B | 0016607 | cellular_component | nuclear speck |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
B | 0030054 | cellular_component | cell junction |
B | 0032922 | biological_process | circadian regulation of gene expression |
B | 0034356 | biological_process | NAD biosynthesis via nicotinamide riboside salvage pathway |
B | 0042802 | molecular_function | identical protein binding |
B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
B | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
B | 0048511 | biological_process | rhythmic process |
B | 0051770 | biological_process | positive regulation of nitric-oxide synthase biosynthetic process |
B | 0060612 | biological_process | adipose tissue development |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue PO4 A 501 |
Chain | Residue |
A | ARG392 |
A | SER398 |
A | LYS400 |
A | HOH611 |
A | HOH615 |
A | HOH828 |
B | GOL502 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue GOL A 502 |
Chain | Residue |
A | ASP354 |
B | LYS423 |
B | PO4501 |
B | HOH635 |
A | ASP313 |
A | GLY353 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | PHE123 |
A | VAL124 |
A | ARG434 |
A | ASN479 |
A | HOH617 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | VAL300 |
A | HOH610 |
A | HOH633 |
B | ASP184 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ASN396 |
A | ASP420 |
A | HOH707 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | LEU13 |
A | ALA14 |
A | HOH654 |
B | TYR195 |
B | GLN201 |
B | ALA222 |
B | HOH654 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | TYR54 |
A | GLY385 |
A | LYS389 |
A | LEU390 |
A | HOH766 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue GOL A 508 |
Chain | Residue |
A | TYR64 |
A | LYS68 |
A | LEU226 |
A | TYR230 |
A | HOH626 |
A | HOH808 |
A | HOH831 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue GOL A 509 |
Chain | Residue |
A | TYR240 |
A | SER241 |
A | VAL242 |
B | HIS90 |
site_id | AD1 |
Number of Residues | 1 |
Details | binding site for residue GOL A 510 |
Chain | Residue |
A | GLU187 |
site_id | AD2 |
Number of Residues | 20 |
Details | binding site for residue 96Q A 511 |
Chain | Residue |
A | TYR188 |
A | HIS191 |
A | PHE193 |
A | ARG196 |
A | LYS216 |
A | GLY217 |
A | ASP219 |
A | TYR240 |
A | VAL242 |
A | ALA244 |
A | SER275 |
A | ARG311 |
A | ARG349 |
A | ALA379 |
A | HOH697 |
A | HOH751 |
A | HOH765 |
A | HOH842 |
B | TYR18 |
B | GLN92 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue PO4 B 501 |
Chain | Residue |
A | GOL502 |
B | ARG40 |
B | ARG392 |
B | SER398 |
B | LYS400 |
B | HOH629 |
B | HOH634 |
B | HOH635 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue GOL B 502 |
Chain | Residue |
A | LYS423 |
A | PO4501 |
B | ASP313 |
B | GLY353 |
B | ASP354 |
site_id | AD5 |
Number of Residues | 3 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
B | GLN63 |
B | TYR230 |
B | TYR231 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue GOL B 504 |
Chain | Residue |
B | TYR471 |
B | GLU475 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue GOL B 505 |
Chain | Residue |
B | PHE123 |
B | VAL124 |
B | ARG434 |
B | PHE440 |
B | ASN479 |
site_id | AD8 |
Number of Residues | 10 |
Details | binding site for residue GOL B 506 |
Chain | Residue |
B | ARG477 |
B | HOH620 |
B | HOH702 |
B | LYS169 |
B | GLU187 |
B | LEU212 |
B | VAL213 |
B | ASN214 |
B | PHE215 |
B | LYS216 |
site_id | AD9 |
Number of Residues | 18 |
Details | binding site for residue 96Q B 507 |
Chain | Residue |
A | TYR18 |
A | GLN92 |
A | HOH760 |
B | TYR188 |
B | HIS191 |
B | PHE193 |
B | ARG196 |
B | LYS216 |
B | ASP219 |
B | TYR240 |
B | VAL242 |
B | ALA244 |
B | SER275 |
B | ARG311 |
B | ARG349 |
B | HOH715 |
B | HOH734 |
B | HOH999 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG392 | |
B | ARG196 | |
B | ASP219 | |
B | HIS247 | |
B | ARG311 | |
B | GLY353 | |
B | GLY384 | |
B | ARG392 | |
A | ARG196 | |
A | ASP219 | |
A | HIS247 | |
A | ARG311 | |
A | GLY353 | |
A | GLY384 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895 |
Chain | Residue | Details |
B | MET1 | |
A | MET1 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | TYR188 | |
B | TYR188 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER472 | |
B | SER472 |