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5N2S

Crystal structure of stabilized A1 receptor in complex with PSB36 at 3.3A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0001609molecular_functionG protein-coupled adenosine receptor activity
A0001659biological_processtemperature homeostasis
A0001664molecular_functionG protein-coupled receptor binding
A0001666biological_processresponse to hypoxia
A0001883molecular_functionpurine nucleoside binding
A0001973biological_processG protein-coupled adenosine receptor signaling pathway
A0002087biological_processregulation of respiratory gaseous exchange by nervous system process
A0002674biological_processnegative regulation of acute inflammatory response
A0002686biological_processnegative regulation of leukocyte migration
A0002793biological_processpositive regulation of peptide secretion
A0003084biological_processpositive regulation of systemic arterial blood pressure
A0003085biological_processnegative regulation of systemic arterial blood pressure
A0003093biological_processregulation of glomerular filtration
A0004930molecular_functionG protein-coupled receptor activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006612biological_processprotein targeting to membrane
A0006909biological_processphagocytosis
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007267biological_processcell-cell signaling
A0007399biological_processnervous system development
A0008285biological_processnegative regulation of cell population proliferation
A0009055molecular_functionelectron transfer activity
A0010035biological_processresponse to inorganic substance
A0014050biological_processnegative regulation of glutamate secretion
A0014074biological_processresponse to purine-containing compound
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016323cellular_componentbasolateral plasma membrane
A0020037molecular_functionheme binding
A0022900biological_processelectron transport chain
A0030425cellular_componentdendrite
A0030673cellular_componentaxolemma
A0031072molecular_functionheat shock protein binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0032229biological_processnegative regulation of synaptic transmission, GABAergic
A0032244biological_processpositive regulation of nucleoside transport
A0032279cellular_componentasymmetric synapse
A0032795molecular_functionheterotrimeric G-protein binding
A0032900biological_processnegative regulation of neurotrophin production
A0035307biological_processpositive regulation of protein dephosphorylation
A0042311biological_processvasodilation
A0042321biological_processnegative regulation of circadian sleep/wake cycle, sleep
A0042323biological_processnegative regulation of circadian sleep/wake cycle, non-REM sleep
A0042597cellular_componentperiplasmic space
A0042734cellular_componentpresynaptic membrane
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043195cellular_componentterminal bouton
A0043197cellular_componentdendritic spine
A0043268biological_processpositive regulation of potassium ion transport
A0043410biological_processpositive regulation of MAPK cascade
A0044297cellular_componentcell body
A0044305cellular_componentcalyx of Held
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045776biological_processnegative regulation of blood pressure
A0045777biological_processpositive regulation of blood pressure
A0046888biological_processnegative regulation of hormone secretion
A0046982molecular_functionprotein heterodimerization activity
A0048786cellular_componentpresynaptic active zone
A0050728biological_processnegative regulation of inflammatory response
A0050890biological_processcognition
A0050900biological_processleukocyte migration
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050995biological_processnegative regulation of lipid catabolic process
A0050996biological_processpositive regulation of lipid catabolic process
A0051930biological_processregulation of sensory perception of pain
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0055089biological_processfatty acid homeostasis
A0055117biological_processregulation of cardiac muscle contraction
A0060079biological_processexcitatory postsynaptic potential
A0060292biological_processlong-term synaptic depression
A0070254biological_processmucus secretion
A0070256biological_processnegative regulation of mucus secretion
A0070328biological_processtriglyceride homeostasis
A0086004biological_processregulation of cardiac muscle cell contraction
A0097190biological_processapoptotic signaling pathway
A0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
A0110148biological_processobsolete biomineralization
A1900272biological_processnegative regulation of long-term synaptic potentiation
A1900453biological_processnegative regulation of long-term synaptic depression
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIlALLAIAVDRYLrV
ChainResidueDetails
ASER1198-VAL1214

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
ATRP1007
AILE1102

site_idSWS_FT_FI2
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AALA1116-ALA1138

site_idSWS_FT_FI3
Number of Residues65
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AVAL1139-CYS1151
AVAL1208-ARG1228
AGLU1307-SER1340

site_idSWS_FT_FI4
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
APHE1152-ILE1174

site_idSWS_FT_FI5
Number of Residues46
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AASN1175-CYS1185
AASN1252-SER1281
ACYS1365-SER1372

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
ALEU1186-ALA1207

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AALA1229-TRP1251

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AMET1282-LEU1306

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
AALA1341-PHE1364

site_idSWS_FT_FI10
Number of Residues24
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AILE1373-ILE1397

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
ASER1414

site_idSWS_FT_FI12
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AALA1264

221051

PDB entries from 2024-06-12

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