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5MZG

Crystal structure of mouse MTH1 in complex with TH588

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 2GE A 201
ChainResidue
ATHR8
APHE139
ASO4202
APHE27
AASN33
APHE72
APHE74
ATRP117
AASP119
AASP120
ATRP123

site_idAC2
Number of Residues9
Detailsbinding site for residue SO4 A 202
ChainResidue
ALEU9
ALYS23
AASN33
AGLY34
AGLY36
AGLU56
AMET101
A2GE201
AHOH365

site_idAC3
Number of Residues4
Detailsbinding site for residue SCN A 203
ChainResidue
ALEU108
AASP109
AGLN110
AILE111

site_idAC4
Number of Residues6
Detailsbinding site for residue SCN A 204
ChainResidue
AHIS69
ASER71
AGLY135
BGLY135
BHIS136
BSCN205

site_idAC5
Number of Residues13
Detailsbinding site for residue 2GE B 201
ChainResidue
BTYR7
BTHR8
BLEU9
BPHE27
BASN33
BPHE72
BPHE74
BTRP117
BASP119
BASP120
BTRP123
BPHE139
BSO4202

site_idAC6
Number of Residues7
Detailsbinding site for residue SO4 B 202
ChainResidue
BLYS23
BASN33
BGLY34
BGLY36
BGLU56
B2GE201
BHOH314

site_idAC7
Number of Residues3
Detailsbinding site for residue SO4 B 203
ChainResidue
BTYR7
BPHE27
BGLN140

site_idAC8
Number of Residues4
Detailsbinding site for residue SCN B 204
ChainResidue
BPRO103
BGLN104
BTRP105
BHOH320

site_idAC9
Number of Residues7
Detailsbinding site for residue SCN B 205
ChainResidue
AGLY135
AHIS136
ASER149
ASCN204
BHIS69
BSER71
BGLY135

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGAkRELlEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:29281266, ECO:0007744|PDB:5MZE
ChainResidueDetails
AASN33
APHE35
ATRP117
BTHR8
BLYS23
BASN33
BPHE35
BTRP117
ATHR8
ALYS23

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
AGLU100
BGLY36
BGLU52
BGLU55
BGLU56
BGLU100
AGLY36
AGLU52
AGLU55
AGLU56

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PDB entries from 2024-06-12

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