Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MZF

Crystal structure of dog MTH1 protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006152	biological_process	purine nucleoside catabolic process
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0008828	molecular_function	dATP diphosphatase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0031965	cellular_component	nuclear membrane
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042262	biological_process	DNA protection
A	0046872	molecular_function	metal ion binding
A	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
A	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
A	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
A	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
B	0001669	cellular_component	acrosomal vesicle
B	0003723	molecular_function	RNA binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006152	biological_process	purine nucleoside catabolic process
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0008828	molecular_function	dATP diphosphatase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0031965	cellular_component	nuclear membrane
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042262	biological_process	DNA protection
B	0046872	molecular_function	metal ion binding
B	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
B	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
B	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
B	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
C	0001669	cellular_component	acrosomal vesicle
C	0003723	molecular_function	RNA binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006152	biological_process	purine nucleoside catabolic process
C	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C	0008828	molecular_function	dATP diphosphatase activity
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0031965	cellular_component	nuclear membrane
C	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C	0042262	biological_process	DNA protection
C	0046872	molecular_function	metal ion binding
C	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
C	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
C	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
C	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
D	0001669	cellular_component	acrosomal vesicle
D	0003723	molecular_function	RNA binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006152	biological_process	purine nucleoside catabolic process
D	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
D	0008828	molecular_function	dATP diphosphatase activity
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0031965	cellular_component	nuclear membrane
D	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
D	0042262	biological_process	DNA protection
D	0046872	molecular_function	metal ion binding
D	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
D	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
D	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
D	0106433	molecular_function	O6-methyl-dGTP hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 201

Chain	Residue
A	HIS65
A	LYS66
A	LYS132
A	HOH310

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
A	TYR7
A	THR8
A	LEU9
A	PHE27
A	ACT203

site_id	AC3
Number of Residues	7
Details	binding site for residue ACT A 203

Chain	Residue
A	ASN33
A	PHE72
A	TRP117
A	ASP119
A	ASP120
A	SO4202
A	HOH308

site_id	AC4
Number of Residues	8
Details	binding site for residue ACT A 204

Chain	Residue
A	GLY21
A	MET22
A	LYS23
A	ASN33
A	GLY34
A	PHE35
A	GLU56
A	MET101

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 205

Chain	Residue
A	PHE113
A	SER121
A	PHE124
A	GOL206
D	PHE113
D	SER121

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 206

Chain	Residue
A	PRO125
A	LEU128
A	GLN129
A	GOL205
D	LEU128

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 B 201

Chain	Residue
B	ASP147
B	TYR148

site_id	AC8
Number of Residues	5
Details	binding site for residue ACT B 202

Chain	Residue
B	ASN33
B	PHE72
B	TRP117
B	ASP119
B	HOH312

site_id	AC9
Number of Residues	3
Details	binding site for residue ACT B 203

Chain	Residue
B	TYR136
B	ARG138
B	ASP147

site_id	AD1
Number of Residues	3
Details	binding site for residue CL B 204

Chain	Residue
B	GLY76
B	GLY141
B	HOH371

site_id	AD2
Number of Residues	1
Details	binding site for residue SO4 C 202

Chain	Residue
C	LYS24

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 C 203

Chain	Residue
C	HIS65
C	LYS66
C	LYS132

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 C 204

Chain	Residue
A	ARG54
C	ARG151
C	HOH354

site_id	AD5
Number of Residues	4
Details	binding site for residue ACT C 205

Chain	Residue
C	ASN33
C	TRP117
C	ASP119
C	HOH305

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL C 206

Chain	Residue
B	PHE113
B	SER121
B	PRO125
C	PHE113
C	SER121
C	PRO125

site_id	AD7
Number of Residues	2
Details	binding site for residue SO4 D 201

Chain	Residue
D	HIS65
D	LYS66

site_id	AD8
Number of Residues	5
Details	binding site for residue ACT D 202

Chain	Residue
D	ASN33
D	PHE72
D	TRP117
D	ASP119
D	HOH305

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GkvqegEtiedGAkRELrEEsG

Chain	Residue	Details
A	GLY37-GLY58

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P36639

Chain	Residue	Details
A	THR114
B	ARG5
B	LEU20
B	GLY30
B	TRP32
B	THR114
C	ARG5
C	LEU20
C	GLY30
C	TRP32
C	THR114
D	ARG5
D	LEU20
D	GLY30
D	TRP32
D	THR114
A	ARG5
A	LEU20
A	GLY30
A	TRP32

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q7ZWC3

Chain	Residue	Details
B	LEU53
B	GLU97
C	ASN33
C	ALA49
C	GLU52
C	LEU53
C	GLU97
D	ASN33
D	ALA49
D	GLU52
D	LEU53
D	GLU97
A	ASN33
A	ALA49
A	GLU52
A	LEU53
A	GLU97
B	ASN33
B	ALA49
B	GLU52

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)