5MSO

Structure of the R domain of carboxylic acid reductase (CAR) from Mycobacterium marinum in complex with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001676	biological_process	long-chain fatty acid metabolic process
A	0004467	molecular_function	long-chain fatty acid-CoA ligase activity
A	0005524	molecular_function	ATP binding
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0031177	molecular_function	phosphopantetheine binding
A	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue NAP A 1201

Chain	Residue
A	GLY785
A	LYS855
A	PRO880
A	ALA881
A	ALA882
A	THR919
A	SER920
A	TYR956
A	LYS960
A	HOH1329
A	HOH1341
A	THR787
A	HOH1381
A	HOH1395
A	HOH1401
A	HOH1404
A	HOH1409
A	HOH1439
A	HOH1517
A	HOH1569
A	HOH1587
A	GLY788
A	PHE789
A	LEU790
A	GLY791
A	ARG814
A	ARG824
A	ASP854

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SatravddsyAngYSNSKWAGeVLLrEAH

Chain	Residue	Details
A	SER943-HIS971

---

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. LIYTSGSTGaPK

Chain	Residue	Details
A	LEU250-LYS261

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02247

Chain	Residue	Details
A	GLU413
A	THR418
A	ASP491
A	TYR503
A	LYS512
A	LYS612
A	HIS297
A	SER392

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:28719588, ECO:0007744|PDB:5MSO, ECO:0007744|PDB:5MSU

Chain	Residue	Details
A	THR787
A	THR919

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02247, ECO:0000269|PubMed:28719588, ECO:0007744|PDB:5MSO, ECO:0007744|PDB:5MSU

Chain	Residue	Details
A	ASP854
A	PRO880
A	TYR956
A	LYS960
A	ARG814
A	ARG824

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|HAMAP-Rule:MF_02247

Chain	Residue	Details
A	SER685

---